2014
Automated Quantitative Analysis of Tissue Microarray of 443 Patients with Colorectal Adenocarcinoma: Low Expression of Bcl-2 Predicts Poor Survival
Nicholson AD, Guo X, Sullivan CA, Cha CH. Automated Quantitative Analysis of Tissue Microarray of 443 Patients with Colorectal Adenocarcinoma: Low Expression of Bcl-2 Predicts Poor Survival. Journal Of The American College Of Surgeons 2014, 219: 977-987. PMID: 25127509, DOI: 10.1016/j.jamcollsurg.2014.07.007.Peer-Reviewed Original ResearchConceptsDisease-specific survivalBcl-2 expressionColorectal cancerOverall survivalPoor disease-specific survivalCox proportional hazards modelIndependent prognostic factorSubset of patientsColorectal adenocarcinoma samplesLog-rank testBcl-2Proportional hazards modelSemi-quantitative grading methodsColorectal cancer samplesNumber of cancersPrognostic factorsT stageChemotherapy choiceClinicopathologic variablesColorectal adenocarcinomaUnivariate analysisPatient outcomesPoor survivalTissue microarrayAggressive phenotype
2009
Tissue Microarray Analysis of 560 Patients with Colorectal Adenocarcinoma: High Expression of HuR Predicts Poor Survival
Yoo PS, Sullivan CA, Kiang S, Gao W, Uchio EM, Chung GG, Cha CH. Tissue Microarray Analysis of 560 Patients with Colorectal Adenocarcinoma: High Expression of HuR Predicts Poor Survival. Annals Of Surgical Oncology 2009, 16: 200. PMID: 19009247, DOI: 10.1245/s10434-008-0209-3.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedAged, 80 and overAntigens, SurfaceAutomationBiomarkers, TumorColorectal NeoplasmsELAV ProteinsELAV-Like Protein 1FemaleFollow-Up StudiesHumansImage Processing, Computer-AssistedImmunoenzyme TechniquesMaleMiddle AgedNeoplasm StagingPlatelet Endothelial Cell Adhesion Molecule-1PrognosisRNA-Binding ProteinsSurvival RateTissue Array AnalysisVascular Endothelial Growth Factor AYoung AdultConceptsVascular endothelial growth factorColorectal adenocarcinomaPoor survivalHuR expressionKaplan-Meier analysisNovel therapeutic targetTissue microarray analysisEndothelial growth factorChi-squared testInstitutional review boardHuR protein expressionAdvanced diseaseClinical outcomesHighest quartileIndependent predictorsPrognostic significanceColorectal cancerCox regressionTumor stageMetastasis stageColorectal carcinomaLowest quartileClinical dataExpression of HuRTissue microarray