2020
Identification of amygdala-expressed genes associated with autism spectrum disorder
Herrero MJ, Velmeshev D, Hernandez-Pineda D, Sethi S, Sorrells S, Banerjee P, Sullivan C, Gupta AR, Kriegstein AR, Corbin JG. Identification of amygdala-expressed genes associated with autism spectrum disorder. Molecular Autism 2020, 11: 39. PMID: 32460837, PMCID: PMC7251751, DOI: 10.1186/s13229-020-00346-1.Peer-Reviewed Original ResearchConceptsASD susceptibility genesSusceptibility genesSingle-nucleus RNA-seq dataCohort of genesIdentification of hundredsRNA-seq dataCell-type specificityAvailable gene expression databasesGene expression analysisGene expression databaseSpecific cell typesEarly developmental stagesHuman tissuesSeq analysisGene sets
2017
The scaffolding protein NHERF1 regulates the stability and activity of the tyrosine kinase HER2
Jeong J, VanHouten JN, Kim W, Dann P, Sullivan C, Choi J, Sneddon WB, Friedman PA, Wysolmerski JJ. The scaffolding protein NHERF1 regulates the stability and activity of the tyrosine kinase HER2. Journal Of Biological Chemistry 2017, 292: 6555-6568. PMID: 28235801, PMCID: PMC5399107, DOI: 10.1074/jbc.m116.770883.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid MotifsAnimalsApoptosisBreast NeoplasmsCalciumCell Line, TumorCell MembraneCell ProliferationFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticGene Knockdown TechniquesHSP90 Heat-Shock ProteinsHumansMiceMicroscopy, FluorescencePhosphoproteinsPlasma Membrane Calcium-Transporting ATPasesReceptor, ErbB-2RNA, MessengerSignal TransductionSodium-Hydrogen ExchangersConceptsBreast cancerHER2-positive breast cancerHER2-positive statusInvasive breast cancerHuman ductal carcinomaDegradation of HER2Normal mammary epithelial cellsMalignant breast cellsBreast cancer cellsErbB2/HER2Tyrosine kinase HER2Sodium-hydrogen exchanger regulatory factor-1Ductal carcinomaHER2 expressionExchanger regulatory factor 1Mammary epithelial cellsHER2Regulatory factor 1NHERF1 expressionBreast cellsEpithelial cellsCancerCancer cellsFactor 1PMCA2
2008
Biomarker Validation: In Situ Analysis of Protein Expression Using Semiquantitative Immunohistochemistry-Based Techniques
Sullivan CA, Chung GG. Biomarker Validation: In Situ Analysis of Protein Expression Using Semiquantitative Immunohistochemistry-Based Techniques. Clinical Colorectal Cancer 2008, 7: 172-177. PMID: 18621634, DOI: 10.3816/ccc.2008.n.022.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkers, TumorGene Expression ProfilingGenomicsHumansImmunohistochemistryProteomicsTissue Array AnalysisConceptsProteomic high-throughput technologiesProtein expressionExpression profile dataHigh-throughput technologiesDrug development targetsMicroarray technologyImmunohistochemistry-based assessmentArchived samplesCancer researchExpressionTissue microarray technologyTissue samplesAbundanceSitu analysisAbundance of data