2017
Stress-Induced Neuronal Colony Stimulating Factor 1 Provokes Microglia-Mediated Neuronal Remodeling and Depressive-like Behavior
Wohleb ES, Terwilliger R, Duman CH, Duman RS. Stress-Induced Neuronal Colony Stimulating Factor 1 Provokes Microglia-Mediated Neuronal Remodeling and Depressive-like Behavior. Biological Psychiatry 2017, 83: 38-49. PMID: 28697890, PMCID: PMC6506225, DOI: 10.1016/j.biopsych.2017.05.026.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnxietyChronic DiseaseDepressive DisorderDisease Models, AnimalFemaleMacrophage Colony-Stimulating FactorMaleMice, Inbred C57BLMice, TransgenicMicrogliaNeuronal PlasticityNeuronsPhagocytosisPrefrontal CortexReceptor, Macrophage Colony-Stimulating FactorRNA, MessengerSex CharacteristicsStress, PsychologicalUncertaintyConceptsDepressive-like behaviorChronic unpredictable stressMedial prefrontal cortexDendritic spine densityNeuronal remodelingSynaptic deficitsDevelopment of anxietyMessenger RNA levelsPrefrontal cortexSpine densityFemale miceFunctional changesStress exposureNeuron-microglia interactionsRNA levelsChronic stress exposureStress-induced elevationPostmortem dorsolateral prefrontal cortexDorsolateral prefrontal cortexBehavioral consequencesNeuronal atrophyPyramidal neuronsMicroglia functionMale miceUnpredictable stress
2005
Neurobiology and Treatment of Anxiety: Signal Transduction and Neural Plasticity
Duman C, Duman R. Neurobiology and Treatment of Anxiety: Signal Transduction and Neural Plasticity. Handbook Of Experimental Pharmacology 2005, 169: 305-334. PMID: 16594263, DOI: 10.1007/3-540-28082-0_11.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAnimalsAntidepressive AgentsAnxietyFearHumansMemoryNeuronal PlasticitySecond Messenger SystemsSignal TransductionConceptsCAMP response element-binding proteinSignaling pathwaysAdditional signaling pathwaysIntracellular signaling pathwaysResponse element-binding proteinElement-binding proteinTreatment of anxietyNeuronal plasticitySignal transductionAnxiolytic effectivenessChronic antidepressant actionBinding proteinCellular mechanismsChronic antidepressant treatmentFunctional plasticityImportance of mechanismsPathophysiology of anxietyPathwayPlasticityProteinAntidepressant treatmentAntidepressant actionFunctional outcomeMolecular alterationsTreatment strategies