2020
Medial PFC AMPA receptor and BDNF signaling are required for the rapid and sustained antidepressant-like effects of 5-HT1A receptor stimulation
Fukumoto K, Fogaça M, Liu RJ, Duman CH, Li XY, Chaki S, Duman RS. Medial PFC AMPA receptor and BDNF signaling are required for the rapid and sustained antidepressant-like effects of 5-HT1A receptor stimulation. Neuropsychopharmacology 2020, 45: 1725-1734. PMID: 32396921, PMCID: PMC7419563, DOI: 10.1038/s41386-020-0705-0.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorAntidepressant-like effectsMajor depressive disorderMedial prefrontal cortexMPFC infusionSelective stimulationReceptor antagonistAMPA receptorsNon-competitive N-methyl-D-aspartate (NMDA) receptor antagonistTreatment of MDDN-methyl-D-aspartate receptor antagonistSynaptic functionAntidepressant-like actionNovelty-suppressed feedingAMPA receptor antagonistGlutamate AMPA receptorsMPFC 5Antidepressant effectsNeurotrophic factorReceptor agonistDepressive disorderSerotonergic systemReceptor stimulationReceptor activationSynaptic proteins
2014
REDD1 is essential for stress-induced synaptic loss and depressive behavior
Ota KT, Liu RJ, Voleti B, Maldonado-Aviles JG, Duric V, Iwata M, Dutheil S, Duman C, Boikess S, Lewis DA, Stockmeier CA, DiLeone RJ, Rex C, Aghajanian GK, Duman RS. REDD1 is essential for stress-induced synaptic loss and depressive behavior. Nature Medicine 2014, 20: 531-535. PMID: 24728411, PMCID: PMC4016190, DOI: 10.1038/nm.3513.Peer-Reviewed Original Research
2013
Evaluating Effects of EPO in Rodent Behavioral Assays Related to Depression
Duman C, Newton S. Evaluating Effects of EPO in Rodent Behavioral Assays Related to Depression. Methods In Molecular Biology 2013, 982: 127-140. PMID: 23456866, DOI: 10.1007/978-1-62703-308-4_8.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsForced-swim testNeurotrophic actionsNovel object recognition testPotential antidepressant propertiesTreatment of depressionTissue-protective propertiesObject recognition testPotential therapeutic utilityEffect of erythropoietinRodent behavioral modelsAntidepressant propertiesDepressive disorderRodent modelsTherapeutic utilityRodent behavioral assaysNeurotrophic compoundsHyponeophagia testErythropoietinCytokine erythropoietinDepressionImportant regulatorBehavioral assaysProtective propertiesRecognition testAntidepressants