2024
Trends in use of intensive care during hospitalizations at the end‐of‐life among older adults with advanced cancer
Jain S, Long J, Rao V, Law A, Walkey A, Prsic E, Lindenauer P, Krumholz H, Gross C. Trends in use of intensive care during hospitalizations at the end‐of‐life among older adults with advanced cancer. Journal Of The American Geriatrics Society 2024 PMID: 39090970, DOI: 10.1111/jgs.19119.Peer-Reviewed Original ResearchEnd-of-life hospitalizationsLife-sustaining treatmentEnd-of-lifeIntensity of careIn-hospital deathOlder adultsIntensive care unitAdvanced cancerRisk-adjusted hospitalEvaluate trendsIncreased intensity of careIntensive care unit useSEER-Medicare dataIntensive care unit careMultinomial regression modelsYear of diagnosisIntensive careHospital categoryMedicare beneficiariesSEER-MedicareHospitalization ratesCareCancer characteristicsNoninvasive ventilationHospitalImmunotherapy utilization patterns in patients with advanced cancer and autoimmune disease
Li H, Huntington S, Gross C, Wang S. Immunotherapy utilization patterns in patients with advanced cancer and autoimmune disease. PLOS ONE 2024, 19: e0300789. PMID: 38625861, PMCID: PMC11020359, DOI: 10.1371/journal.pone.0300789.Peer-Reviewed Original ResearchConceptsAutoimmune diseasesImmunotherapy cycleFirst-lineNon-small cell lung cancerAdvanced cancerFirst-line immunotherapyOverall treatment toleranceCell lung cancerRenal cell carcinomaRetrospective cohort studyAssociated with lower oddsAdvanced melanomaCell carcinomaTreatment toleranceAbsolute contraindicationImmunotherapyConsensus guidelinesImprove cancer survivalLung cancerCohort studyClinical variablesCancer patientsAcademic centersPatientsIncidence rate
2021
Impact of COVID-19 pandemic on time to treatment initiation for patients with advanced cancer.
Takvorian S, Parikh R, Vader D, Wileyto E, Clark A, Lee D, Goyal G, Rocque G, Dotan E, Geynisman D, Phull P, Spiess P, Kim R, Davidoff A, Gross C, Miksad R, Calip G, Shulman L, Mamtani R, Hubbard R. Impact of COVID-19 pandemic on time to treatment initiation for patients with advanced cancer. Journal Of Clinical Oncology 2021, 39: 1528-1528. DOI: 10.1200/jco.2021.39.15_suppl.1528.Peer-Reviewed Original ResearchAdvanced solid cancersTreatment initiationAdvanced cancer diagnosisAdvanced cancerSolid cancersCancer typesCox proportional hazards modelCOVID-19 pandemicSystemic therapy initiationSystemic treatment initiationTimely care deliveryDe novo cancerDe novo diseaseAdvanced breast cancerCancer diagnosisLife-prolonging therapiesProportional hazards modelInterrupted time series analysisDe-identified databaseProbability of treatmentNovo diseaseTherapy initiationNovo cancerPerformance statusClinical outcomes
2019
Affordable Care Act (ACA) Medicaid expansion impact on racial disparities in time to cancer treatment.
Adamson B, Cohen A, Estevez M, Magee K, Williams E, Gross C, Meropol N, Davidoff A. Affordable Care Act (ACA) Medicaid expansion impact on racial disparities in time to cancer treatment. Journal Of Clinical Oncology 2019, 37: lba1-lba1. DOI: 10.1200/jco.2019.37.18_suppl.lba1.Peer-Reviewed Original ResearchTimely treatmentMedicaid expansionRacial disparitiesFlatiron Health electronic health record-derived databaseElectronic health record-derived databaseCancer ptsDiagnosis dateTreatment startAdvanced cancerMetastatic diagnosisCancer outcomesMetastatic cancerState of residenceHealthcare accessAge 18Private insuranceCancer typesExpansion statusTreatment overallCancer treatmentPractice typeTreatmentAfrican AmericansOutcomesCancer
2012
Factors associated with life expectancy (LE) < 3 months (mo) among older adults receiving palliative chemotherapy (chemo).
Hurria A, Hardt M, Tew W, Mohile S, Owusu C, Gross C, Gajra A, Lichtman S, Katheria V, Ramani R, Zavala L, Klepin H. Factors associated with life expectancy (LE) < 3 months (mo) among older adults receiving palliative chemotherapy (chemo). Journal Of Clinical Oncology 2012, 30: 9034-9034. DOI: 10.1200/jco.2012.30.15_suppl.9034.Peer-Reviewed Original ResearchUnintentional weight lossPoor physical functionMultivariate logistic regressionAdvanced cancerLife expectancyPhysical functionWeight lossBivariate analysisLogistic regressionOlder adultsGeriatric assessment variablesMulti-site cohort studyLimited life expectancyPhysical function measuresFunctional status measuresOlder ptsPalliative chemoPalliative chemotherapyPalliative intentCohort studyPatient ageLow albuminFunctional statusOptimal treatmentRisk factors
2011
Primary dose reduction (PDR) of chemotherapy (chemo) in patients (Pts) older than age 65 with advanced cancer (Ca) and toxicity outcomes.
Gajra A, Hardt M, Tew W, Mohile S, Owusu C, Klepin H, Gross C, Lichtman S, Ramani R, Brown J, Katheria V, Jayani R, Hansen K, Togawa K, Klapper S, Hurria A. Primary dose reduction (PDR) of chemotherapy (chemo) in patients (Pts) older than age 65 with advanced cancer (Ca) and toxicity outcomes. Journal Of Clinical Oncology 2011, 29: 9037-9037. DOI: 10.1200/jco.2011.29.15_suppl.9037.Peer-Reviewed Original Research