1990
Enhanced Susceptibility to Histamine-Induced Cardiac Arrhythmias in Spontaneously Hypertensive Rats
Cameron J, Swigart C, Shin G, Katz D, Bassett A. Enhanced Susceptibility to Histamine-Induced Cardiac Arrhythmias in Spontaneously Hypertensive Rats. Journal Of Cardiovascular Pharmacology 1990, 15: 626-632. PMID: 1691394, DOI: 10.1097/00005344-199004000-00016.Peer-Reviewed Original ResearchConceptsIncidence of arrhythmiasSpontaneous firing rateAction potential durationHypertensive ratsH2-receptor blocker cimetidineFiring rateElevated intracellular calcium levelsSpontaneously Hypertensive RatsBody weight ratioLevels of repolarizationCardiac rhythm disturbancesChannel antagonist verapamilAge-matched controlsIntracellular calcium levelsEnhanced susceptibilitySHR ventriclesWKY preparationsSHR heartsAntagonist verapamilArrhythmogenic influenceRhythm disturbancesHistamine releaseMyocardial hypertrophySHR myocardiumDrug levels
1989
Histamine attenuates the arrhythmogenic effects of norepinephrine in hearts of spontaneously hypertensive rats
Cameron J, Katz D, Swigart C, Bassett A. Histamine attenuates the arrhythmogenic effects of norepinephrine in hearts of spontaneously hypertensive rats. European Journal Of Pharmacology 1989, 169: 23-31. PMID: 2532144, DOI: 10.1016/0014-2999(89)90813-3.Peer-Reviewed Original ResearchConceptsHypertensive ratsArrhythmogenic effectsH2-receptor antagonist cimetidineSetting of hypertensionBody weight ratioLevels of repolarizationSpontaneous firing rateNorepinephrine-induced increaseSex-matched controlsAction potential durationCardiac histamineSHR ventriclesWKY preparationsAdrenoceptor functionHypertensive heartAntagonist cimetidineRhythm disturbancesMyocardial hypertrophyPotential durationDrug AdministrationLeft ventriclePercent incidenceNorepinephrineFiring rateHistamine