Enhanced Susceptibility to Histamine-Induced Cardiac Arrhythmias in Spontaneously Hypertensive Rats
Cameron J, Swigart C, Shin G, Katz D, Bassett A. Enhanced Susceptibility to Histamine-Induced Cardiac Arrhythmias in Spontaneously Hypertensive Rats. Journal Of Cardiovascular Pharmacology 1990, 15: 626-632. PMID: 1691394, DOI: 10.1097/00005344-199004000-00016.Peer-Reviewed Original ResearchConceptsIncidence of arrhythmiasSpontaneous firing rateAction potential durationHypertensive ratsH2-receptor blocker cimetidineFiring rateElevated intracellular calcium levelsSpontaneously Hypertensive RatsBody weight ratioLevels of repolarizationCardiac rhythm disturbancesChannel antagonist verapamilAge-matched controlsIntracellular calcium levelsEnhanced susceptibilitySHR ventriclesWKY preparationsSHR heartsAntagonist verapamilArrhythmogenic influenceRhythm disturbancesHistamine releaseMyocardial hypertrophySHR myocardiumDrug levels