Histamine attenuates the arrhythmogenic effects of norepinephrine in hearts of spontaneously hypertensive rats
Cameron J, Katz D, Swigart C, Bassett A. Histamine attenuates the arrhythmogenic effects of norepinephrine in hearts of spontaneously hypertensive rats. European Journal Of Pharmacology 1989, 169: 23-31. PMID: 2532144, DOI: 10.1016/0014-2999(89)90813-3.Peer-Reviewed Original ResearchConceptsHypertensive ratsArrhythmogenic effectsH2-receptor antagonist cimetidineSetting of hypertensionBody weight ratioLevels of repolarizationSpontaneous firing rateNorepinephrine-induced increaseSex-matched controlsAction potential durationCardiac histamineSHR ventriclesWKY preparationsAdrenoceptor functionHypertensive heartAntagonist cimetidineRhythm disturbancesMyocardial hypertrophyPotential durationDrug AdministrationLeft ventriclePercent incidenceNorepinephrineFiring rateHistamine