2011
Subclinical vitamin A deficiency does not increase development of tumors in irradiated or unirradiated lungs
Rockwell S, Liu Y, Mayne ST, Redlich CA. Subclinical vitamin A deficiency does not increase development of tumors in irradiated or unirradiated lungs. Experimental Biology And Medicine 2011, 236: 1173-1179. PMID: 21844122, PMCID: PMC3207150, DOI: 10.1258/ebm.2011.011082.Peer-Reviewed Original ResearchConceptsWhole lung irradiationSubclinical vitaminSpontaneous lung metastasesLung metastasesLung tumorsVitamin ALung irradiationTumor cellsLow vitaminDeficient dietSubcutaneous tumorsPossible modifiable risk factorsSeverity of pneumonitisModifiable risk factorsRadiation-induced pneumonitisEnhancement of metastasisImpact of vitaminDose-dependent increaseLevels of retinolGrowth of tumorsDevelopment of tumorsDose-response curveLung injuryLung levelsPrimary cancer
2005
Evidence for Excess Colorectal Cancer Incidence among Asbestos-exposed Men in the Beta-Carotene and Retinol Efficacy Trial
Aliyu OA, Cullen MR, Barnett MJ, Balmes JR, Cartmel B, Redlich CA, Brodkin CA, Barnhart S, Rosenstock L, Israel L, Goodman GE, Thornquist MD, Omenn GS. Evidence for Excess Colorectal Cancer Incidence among Asbestos-exposed Men in the Beta-Carotene and Retinol Efficacy Trial. American Journal Of Epidemiology 2005, 162: 868-878. PMID: 16177148, DOI: 10.1093/aje/kwi285.Peer-Reviewed Original ResearchConceptsRetinol Efficacy TrialColorectal cancer riskHeavy smokersColorectal cancerAsbestos exposureRelative riskEfficacy trialsCancer riskBeta caroteneAsbestos-exposed menColorectal cancer incidenceMale heavy smokersProportional hazards modelDose-response trendIntervention armPleural plaquesLung cancerRadiographic changesCancer incidencePulmonary asbestosisHazards modelCancerUS studiesSmokersRiskPredictors of Lung Cancer among Asbestos-exposed Men in the β-Carotene and Retinol Efficacy Trial
Cullen MR, Barnett MJ, Balmes JR, Cartmel B, Redlich CA, Brodkin CA, Barnhart S, Rosenstock L, Goodman GE, Hammar SP, Thornquist MD, Omenn GS. Predictors of Lung Cancer among Asbestos-exposed Men in the β-Carotene and Retinol Efficacy Trial. American Journal Of Epidemiology 2005, 161: 260-270. PMID: 15671258, DOI: 10.1093/aje/kwi034.Peer-Reviewed Original ResearchConceptsRetinol Efficacy TrialLung cancerEfficacy trialsAsbestos-exposed menStudy intervention armSubsequent lung cancerStrong independent predictorLung cancer incidenceLung cancer riskNormal lung parenchymaProportional hazards modelBaseline flow ratesRadiographic asbestosisIndependent predictorsStudy armsIntervention armVitamin supplementationPleural plaquesBaseline radiographsResidual confoundingCancer incidenceChest radiographsLung parenchymaLung carcinogenCancer risk
1999
Effect of long-term beta-carotene and vitamin A on serum cholesterol and triglyceride levels among participants in the Carotene and Retinol Efficacy Trial (CARET)
Redlich C, Chung J, Cullen M, Blaner W, Van Bennekum A, Berglund L. Effect of long-term beta-carotene and vitamin A on serum cholesterol and triglyceride levels among participants in the Carotene and Retinol Efficacy Trial (CARET). Atherosclerosis 1999, 145: 425-432. PMID: 10488974, DOI: 10.1016/s0021-9150(99)00266-x.Peer-Reviewed Original ResearchConceptsSerum triglyceride levelsHigh-density lipoproteinActive treatment groupLDL cholesterol levelsTriglyceride levelsCancer chemoprevention trialsCholesterol levelsSmall nonsignificant increaseCARET participantsCardiovascular mortalityTreatment groupsNonsignificant increaseLow-density lipoprotein cholesterol levelsLung cancer chemoprevention trialsRetinol Efficacy TrialActive treatment armsLipoprotein cholesterol levelsLung cancer mortalityLong-term supplementationActive intervention groupTreatment-induced changesSerum lipidsChemoprevention trialsHDL cholesterolActive treatment
1998
Effect of supplementation with beta-carotene and vitamin A on lung nutrient levels.
Redlich CA, Blaner WS, Van Bennekum AM, Chung JS, Clever SL, Holm CT, Cullen MR. Effect of supplementation with beta-carotene and vitamin A on lung nutrient levels. Cancer Epidemiology Biomarkers & Prevention 1998, 7: 211-4. PMID: 9521435.Peer-Reviewed Original ResearchConceptsActive armRetinol levelsLung tissueExcess lung cancer mortalityLung cancer chemoprevention trialsLung retinol levelsRetinol Efficacy TrialLung tissue levelsLung cancer mortalityCancer chemoprevention trialsEffect of supplementationLung retinolChemoprevention trialsCancer mortalitySurgical controlEfficacy trialsCell levelVitamin ARetinyl palmitateSame interventionTissue levelsBiomarker studiesSupplementationInterventionTrials
1996
Characterization of carotenoid, vitamin A, and alpha-tocopheral levels in human lung tissue and pulmonary macrophages.
Redlich CA, Grauer JN, Van Bennekum AM, Clever SL, Ponn RB, Blaner WS. Characterization of carotenoid, vitamin A, and alpha-tocopheral levels in human lung tissue and pulmonary macrophages. American Journal Of Respiratory And Critical Care Medicine 1996, 154: 1436-1443. PMID: 8912761, DOI: 10.1164/ajrccm.154.5.8912761.Peer-Reviewed Original ResearchConceptsLung tissue levelsHuman lung tissueBAL cellsLung tissueAlpha-tocopherolTissue levelsSerum levelsHigh-pressure liquid chromatographyBronchoalveolar lavage cellsOpen lung surgeryFresh lung tissueImportant protective effectDietary questionnaireLung surgeryLavage cellsProtective effectPulmonary macrophagesReverse-phase high-pressure liquid chromatographyVitamin AHuman lungDietary levelsPotential markerRetinolSerumPatientsIL-11 enhances survival and decreases TNF production after radiation-induced thoracic injury.
Redlich C, Gao X, Rockwell S, Kelley M, Elias J. IL-11 enhances survival and decreases TNF production after radiation-induced thoracic injury. The Journal Of Immunology 1996, 157: 1705-10. PMID: 8759759, DOI: 10.4049/jimmunol.157.4.1705.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBronchoalveolar Lavage FluidCell LineGene Expression RegulationGene Expression Regulation, NeoplasticInjections, SubcutaneousInterleukin-11Lung NeoplasmsMacrophages, AlveolarMiceMice, Inbred BALB CNeoplasm ProteinsNeoplastic Stem CellsRadiation Injuries, ExperimentalRecombinant ProteinsRNA, MessengerRNA, NeoplasmSpecific Pathogen-Free OrganismsThoracic InjuriesTumor Necrosis Factor-alphaConceptsThoracic irradiationThoracic injuriesControl miceTNF protein productionTNF productionVehicle-treated control miceNormal thoracic structuresPulmonary metastatic tumorsEMT6 tumor cellsTNF mRNA expressionDose of radiationLung metastasesInhibits LPSMetastatic tumorsNormal lungRadioprotective effectMRNA expressionIL-11Enhances SurvivalTumor cellsObserved protectionSignificant radioprotectionTNF mRNAThoracic structuresStudy interval
1995
Vitamin A Chemoprevention of Lung Cancer
Redlich C, Van Bennekum A, Wirth J, Blaner W, Carter D, Tanoue L, Holm C, Cullen M. Vitamin A Chemoprevention of Lung Cancer. Advances In Experimental Medicine And Biology 1995, 375: 17-29. PMID: 7645426, DOI: 10.1007/978-1-4899-0949-7_2.Peer-Reviewed Original ResearchMeSH KeywordsAnticarcinogenic AgentsBiomarkers, TumorHumansLung NeoplasmsRandomized Controlled Trials as TopicVitamin AConceptsLung cancerParenchymal fibrosisVitamin ABronchoalveolar lavageHigh riskAsbestos-exposed subjectsDouble-blind placeboDietary vitamin ASupplemental vitamin AEffective preventive strategiesPrior clinical studiesPotential early markerProcess of inflammationBiomarkers of susceptibilityBronchial metaplasiaLung inflammationPulmonary cytokinesBronchial biopsiesImmunomodulatory effectsClinical studiesPreventive strategiesHost determinantsHigh incidenceEarly markerFibrosis