2022
Occupational Exposures in Nontuberculous Mycobacterial Pulmonary Disease
Blanc PD, Balmes JR, Redlich C. Occupational Exposures in Nontuberculous Mycobacterial Pulmonary Disease. CHEST Journal 2022, 162: e106-e107. PMID: 35940661, DOI: 10.1016/j.chest.2022.03.049.Commentaries, Editorials and Letters
2020
Analysis of Lung Gene Expression Reveals a Role for Cl- channels in Diisocyanate Induced Airway Eosinophilia in a Mouse Model of Asthma Pathology
Wisnewski AV, Liu J, Redlich CA. Analysis of Lung Gene Expression Reveals a Role for Cl- channels in Diisocyanate Induced Airway Eosinophilia in a Mouse Model of Asthma Pathology. American Journal Of Respiratory Cell And Molecular Biology 2020, 0: 25-35. PMID: 32101465, PMCID: PMC7328250, DOI: 10.1165/rcmb.2019-0400oc.Peer-Reviewed Original ResearchConceptsRespiratory tract exposureAirway eosinophiliaMonocytes/macrophagesMouse modelGene expressionGene transcriptsBiological pathwaysAsthma pathologyUpregulated gene transcriptsIgE-independent mechanismsLung gene expressionLung tissue gene expressionCause of asthmaBALB/cTransgenic B cellsTissue gene expressionExpression changesDiisocyanate asthmaSensitized workersAsthma pathogenesisAirway fluidDeficient miceMRNA microarrayEosinophiliaB cells
2019
Respiratory Health after Military Service in Southwest Asia and Afghanistan. An Official American Thoracic Society Workshop Report
Garshick E, Abraham JH, Baird CP, Ciminera P, Downey GP, Falvo MJ, Hart JE, Jackson DA, Jerrett M, Kuschner W, Helmer DA, Jones KD, Krefft SD, Mallon T, Miller RF, Morris MJ, Proctor SP, Redlich CA, Rose CS, Rull RP, Saers J, Schneiderman AI, Smith NL, Yiallouros P, Blanc PD. Respiratory Health after Military Service in Southwest Asia and Afghanistan. An Official American Thoracic Society Workshop Report. Annals Of The American Thoracic Society 2019, 16: e1-e16. PMID: 31368802, PMCID: PMC6774741, DOI: 10.1513/annalsats.201904-344ws.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsConstrictive bronchiolitisAirway diseaseRespiratory healthOfficial American Thoracic Society Workshop ReportRespiratory tract findingsRespiratory tract abnormalitiesAdverse health conditionsParticulate matter effectsU.S. military personnelLung biopsyLung functionPulmonary functionCase seriesPathologic findingsTract abnormalitiesInhalational exposurePhysiologic changesClinical characterizationAmerican Thoracic Society International ConferenceEpidemiologic studiesBronchiolitisLongitudinal assessmentDeployment exposuresHealth conditionsMore frequent encounters
2017
The Limits of Pattern Recognition: Nodular Lung Disease in a Syrian Refugee
Lefkowitz RY, Mitma AA, Altassan K, Redlich CA. The Limits of Pattern Recognition: Nodular Lung Disease in a Syrian Refugee. Annals Of The American Thoracic Society 2017, 14: 1591-1594. PMID: 28961033, DOI: 10.1513/annalsats.201702-163cc.Peer-Reviewed Case Reports and Technical NotesReaction products of hexamethylene diisocyanate vapors with “self” molecules in the airways of rabbits exposed via tracheostomy
Wisnewski AV, Kanyo J, Asher J, Goodrich JA, Barnett G, Patrylak L, Liu J, Redlich CA, Nassar AF. Reaction products of hexamethylene diisocyanate vapors with “self” molecules in the airways of rabbits exposed via tracheostomy. Xenobiotica 2017, 48: 488-497. PMID: 28489470, PMCID: PMC5863241, DOI: 10.1080/00498254.2017.1329569.Peer-Reviewed Original ResearchConceptsCollision-induced dissociation (CID) fragmentation patternsReaction productsLower airwaysChemical reactivityLow molecular weight fractionWeight fractionHigh molecular weight fractionAliphatic diisocyanateMolecular weight fractionFragmentation patternsHexamethylenediisocyanateLC-MSHDI vaporAirways of rabbitsBronchoalveolar lavage fluidRabbit bronchoalveolar lavage fluidMoleculesDiisocyanate vaporsMs. 4Albumin. 5Occupational asthmaReactivityBAL fluidAsthma pathogenesisLavage fluid
2016
National Institute of Environmental Health Sciences: 50 Years of Advancing Science and Improving Lung Health
Antony VB, Redlich CA, Pinkerton KE, Balmes J, Harkema JR. National Institute of Environmental Health Sciences: 50 Years of Advancing Science and Improving Lung Health. American Journal Of Respiratory And Critical Care Medicine 2016, 194: 1190-1195. PMID: 27668911, DOI: 10.1164/rccm.201608-1645pp.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAmerican Thoracic SocietyLung healthThoracic SocietyEnvironmental Health SciencesNational InstituteNational Toxicology ProgramInvestigator-initiated researchLung diseaseHealth SciencesToxicology ProgramEnvironmental toxinsNIEHSTranslational scienceIntramural programsHealthExtramural programsPathogenesisCliniciansAdvancing ScienceDisease
2015
Longitudinal assessment of lung function decline in the occupational setting
Redlich CA, Tarlo SM. Longitudinal assessment of lung function decline in the occupational setting. Current Opinion In Allergy And Clinical Immunology 2015, 15: 145-149. PMID: 25961387, DOI: 10.1097/aci.0000000000000153.Peer-Reviewed Original ResearchConceptsLongitudinal lung functionLung functionLongitudinal spirometryMedical surveillanceFlavorings-related lung diseaseHazardous work exposuresLung function declineOccupational respiratory diseasesRecent longitudinal studiesFunction declineEarly diseaseLung diseaseOccupational exposureRespiratory diseaseWork exposureSpirometryPreventive interventionsLongitudinal assessmentFurther evaluationOccupational settingsDiseaseLongitudinal studyCliniciansExposureRecent studies
2011
Subclinical vitamin A deficiency does not increase development of tumors in irradiated or unirradiated lungs
Rockwell S, Liu Y, Mayne ST, Redlich CA. Subclinical vitamin A deficiency does not increase development of tumors in irradiated or unirradiated lungs. Experimental Biology And Medicine 2011, 236: 1173-1179. PMID: 21844122, PMCID: PMC3207150, DOI: 10.1258/ebm.2011.011082.Peer-Reviewed Original ResearchConceptsWhole lung irradiationSubclinical vitaminSpontaneous lung metastasesLung metastasesLung tumorsVitamin ALung irradiationTumor cellsLow vitaminDeficient dietSubcutaneous tumorsPossible modifiable risk factorsSeverity of pneumonitisModifiable risk factorsRadiation-induced pneumonitisEnhancement of metastasisImpact of vitaminDose-dependent increaseLevels of retinolGrowth of tumorsDevelopment of tumorsDose-response curveLung injuryLung levelsPrimary cancer
2000
Identification of Human Lung and Skin Proteins Conjugated with Hexamethylene DiisocyanateIn Vitro and In Vivo
WISNEWSKI A, SRIVASTAVA R, HERICK C, XU L, LEMUS R, CAIN H, MAGOSKI N, KAROL M, BOTTOMLY K, REDLICH C. Identification of Human Lung and Skin Proteins Conjugated with Hexamethylene DiisocyanateIn Vitro and In Vivo. American Journal Of Respiratory And Critical Care Medicine 2000, 162: 2330-2336. PMID: 11112159, DOI: 10.1164/ajrccm.162.6.2002086.Peer-Reviewed Original ResearchConceptsDiisocyanate-induced asthmaBiopsy samplesHuman lungHuman airway epithelial cellsBronchoalveolar lavage fluidAirway epithelial cellsEndobronchial biopsy samplesHuman skin biopsy samplesSkin biopsy samplesKeratin 18Epicutaneous exposureLavage fluidSkin proteinsVivo inhalationVivo exposureEpithelial cell proteinsGlucose-regulated proteinEpithelial cellsAsthmaLungExposureVitroVivoKeratinCell proteins
1999
Isocyanate-conjugated human lung epithelial cell proteins: A link between exposure and asthma?
Wisnewski A, Lemus R, Karol M, Redlich C. Isocyanate-conjugated human lung epithelial cell proteins: A link between exposure and asthma? Journal Of Allergy And Clinical Immunology 1999, 104: 341-347. PMID: 10452755, DOI: 10.1016/s0091-6749(99)70377-5.Peer-Reviewed Original ResearchConceptsIsocyanate-induced asthmaHuman lung epithelial cell lineEpithelial cell proteinsLung epithelial cell lineEpithelial cell lineLymphocyte proliferationProliferation of PBMCCell linesAirway inflammationAtopic subjectsNonasthmatic individualsHDI exposureAirway epitheliumImmunostimulatory potentialAsthmaCell proteinsWestern blottingPotential roleProliferationExposureHDI concentrationCross-linking chemicalsCell polypeptidesConjugation patternSubjects
1998
Vitamin A Inhibits Radiation-Induced Pneumonitis in Rats 1 , 2
Redlich C, Rockwell S, Chung J, Sikora A, Kelley M, Mayne S. Vitamin A Inhibits Radiation-Induced Pneumonitis in Rats 1 , 2. Journal Of Nutrition 1998, 128: 1661-1664. PMID: 9772133, DOI: 10.1093/jn/128.10.1661.Peer-Reviewed Original ResearchConceptsRadiation-induced lung injuryVitamin ALung injuryLung inflammationRadiation-induced lung inflammationLung retinol levelsSupplemental vitamin AAltered vitaminThoracic radiationThoracic radiotherapyBronchoalveolar lavagePrescribed dietRetinol levelsDeficient groupDeficient dietTotal doseY ratsRadioprotective agentsRats 1RatsWhole thoraxHost susceptibilityDietInflammationInjuryEffect of supplementation with beta-carotene and vitamin A on lung nutrient levels.
Redlich CA, Blaner WS, Van Bennekum AM, Chung JS, Clever SL, Holm CT, Cullen MR. Effect of supplementation with beta-carotene and vitamin A on lung nutrient levels. Cancer Epidemiology Biomarkers & Prevention 1998, 7: 211-4. PMID: 9521435.Peer-Reviewed Original ResearchConceptsActive armRetinol levelsLung tissueExcess lung cancer mortalityLung cancer chemoprevention trialsLung retinol levelsRetinol Efficacy TrialLung tissue levelsLung cancer mortalityCancer chemoprevention trialsEffect of supplementationLung retinolChemoprevention trialsCancer mortalitySurgical controlEfficacy trialsCell levelVitamin ARetinyl palmitateSame interventionTissue levelsBiomarker studiesSupplementationInterventionTrials
1996
Characterization of carotenoid, vitamin A, and alpha-tocopheral levels in human lung tissue and pulmonary macrophages.
Redlich CA, Grauer JN, Van Bennekum AM, Clever SL, Ponn RB, Blaner WS. Characterization of carotenoid, vitamin A, and alpha-tocopheral levels in human lung tissue and pulmonary macrophages. American Journal Of Respiratory And Critical Care Medicine 1996, 154: 1436-1443. PMID: 8912761, DOI: 10.1164/ajrccm.154.5.8912761.Peer-Reviewed Original ResearchConceptsLung tissue levelsHuman lung tissueBAL cellsLung tissueAlpha-tocopherolTissue levelsSerum levelsHigh-pressure liquid chromatographyBronchoalveolar lavage cellsOpen lung surgeryFresh lung tissueImportant protective effectDietary questionnaireLung surgeryLavage cellsProtective effectPulmonary macrophagesReverse-phase high-pressure liquid chromatographyVitamin AHuman lungDietary levelsPotential markerRetinolSerumPatients
1995
Retinoic acid inhibition of transforming growth factor-beta-induced collagen production by human lung fibroblasts.
Redlich C, Delisser H, Elias J. Retinoic acid inhibition of transforming growth factor-beta-induced collagen production by human lung fibroblasts. American Journal Of Respiratory Cell And Molecular Biology 1995, 12: 287-295. PMID: 7873195, DOI: 10.1165/ajrcmb.12.3.7873195.Peer-Reviewed Original ResearchConceptsHuman lung fibroblastsRetinoic acidCollagen productionChronic inflammatory lung disordersDoses of RALung fibroblastsType IInhibitory effectInflammatory lung disordersTrans retinoic acidFibroblast collagen productionM retinoic acidLung disordersPotent immunomodulatorFibrotic responseRetinoid compoundsType III collagenBasal levelsSignificant inhibitionAcid inhibitionSignificant decreaseRetinoidsUnstimulated cellsPreincubationStimulation