1990
Clinical and pathological characteristics of hepatotoxicity associated with occupational exposure to dimethylformamide
Redlich C, West A, Fleming L, True L, Cullen M, Riely C. Clinical and pathological characteristics of hepatotoxicity associated with occupational exposure to dimethylformamide. Gastroenterology 1990, 99: 748-757. PMID: 2379779, DOI: 10.1016/0016-5085(90)90964-3.Peer-Reviewed Original ResearchConceptsToxic liver injuryLiver injuryDisulfiram-type reactionsFocal hepatocellular necrosisSmooth endoplasmic reticulumProminent smooth endoplasmic reticulumAbnormal aminotransferasesAbdominal painBiopsy findingsClinical characteristicsEnzyme elevationLiver biopsyPleomorphic mitochondriaAcute injuryHepatocellular necrosisMicrovesicular steatosisBiopsy histologyMacrovesicular steatosisPathological characteristicsOccupational exposureAlanine aminotransferaseOccupational historyLonger exposureInjuryAminotransferaseLiver injury in workers exposed to dimethylformamide.
Fleming L, Shalat S, Redlich C. Liver injury in workers exposed to dimethylformamide. Scandinavian Journal Of Work, Environment & Health 1990, 16: 289-92. PMID: 2389137, DOI: 10.5271/sjweh.1782.Peer-Reviewed Original ResearchConceptsToxic liver diseaseGlutamic pyruvic transaminaseLiver diseasePyruvic transaminaseOxaloacetic transaminaseSerum glutamic oxaloacetic transaminaseSerum glutamic pyruvic transaminaseGlutamic oxaloacetic transaminaseLiver transaminasesLiver injuryUnexposed groupOriginal epidemicUnexposed subjectsMedical surveillanceEpidemic clustersOccupational diseasesFurther casesTransaminaseDiseaseCausative agentSignificant differencesPopulationInjuryOccupational clustersMonths
1988
Liver disease associated with occupational exposure to the solvent dimethylformamide.
Redlich C, Beckett W, Sparer J, Barwick K, Riely C, Miller H, Sigal S, Shalat S, Cullen M. Liver disease associated with occupational exposure to the solvent dimethylformamide. Annals Of Internal Medicine 1988, 108: 680-6. PMID: 3358569, DOI: 10.7326/0003-4819-108-5-680.Peer-Reviewed Original ResearchConceptsToxic liver diseaseLiver enzyme abnormalitiesLiver diseaseEnzyme abnormalitiesAspartate aminotransferaseALT levelsBiopsy specimensStandard liver function testsAppropriate skin protectionClinical-epidemiological investigationNegative viral serologyOccupational liver diseaseSymptoms of hepatitisEnzyme levelsLiver function testsLiver biopsy specimensRatio of ASTToxic liver injuryOccupational medicine clinicExtensive clinical evaluationAcademic medical centerViral serologyAminotransferase levelsMost patientsLiver injury