2003
Human γ/δ T-cell proliferation and IFN-γ production induced by hexamethylene diisocyanate
Wisnewski AV, Herrick CA, Liu Q, Chen L, Bottomly K, Redlich CA. Human γ/δ T-cell proliferation and IFN-γ production induced by hexamethylene diisocyanate. Journal Of Allergy And Clinical Immunology 2003, 112: 538-546. PMID: 13679813, DOI: 10.1016/s0091-6749(03)01865-7.Peer-Reviewed Original ResearchConceptsGamma/delta T cellsDelta T cellsHuman immune responseT cellsT cell receptorImmune responseAlpha/beta T cell receptorBeta T cell receptorHuman airway epithelial cellsIFN-γ productionGamma/deltaT cell proliferationAirway epithelial cellsHuman T cell lineT cell linesHuman T cellsCell typesOccupational asthmaCytokine productionPeripheral bloodIL-13IL-5Antigen-mediated selectionAntigen leadIFN-gamma
1999
Isocyanate-conjugated human lung epithelial cell proteins: A link between exposure and asthma?
Wisnewski A, Lemus R, Karol M, Redlich C. Isocyanate-conjugated human lung epithelial cell proteins: A link between exposure and asthma? Journal Of Allergy And Clinical Immunology 1999, 104: 341-347. PMID: 10452755, DOI: 10.1016/s0091-6749(99)70377-5.Peer-Reviewed Original ResearchConceptsIsocyanate-induced asthmaHuman lung epithelial cell lineEpithelial cell proteinsLung epithelial cell lineEpithelial cell lineLymphocyte proliferationProliferation of PBMCCell linesAirway inflammationAtopic subjectsNonasthmatic individualsHDI exposureAirway epitheliumImmunostimulatory potentialAsthmaCell proteinsWestern blottingPotential roleProliferationExposureHDI concentrationCross-linking chemicalsCell polypeptidesConjugation patternSubjects