2021
Scalable inference of transcriptional kinetic parameters from MS2 time series data
Bowles J, Hoppe C, Ashe H, Rattray M. Scalable inference of transcriptional kinetic parameters from MS2 time series data. Bioinformatics 2021, 38: 1030-1036. PMID: 34788793, PMCID: PMC8796374, DOI: 10.1093/bioinformatics/btab765.Peer-Reviewed Original Research
2020
Modulation of the Promoter Activation Rate Dictates the Transcriptional Response to Graded BMP Signaling Levels in the Drosophila Embryo
Hoppe C, Bowles JR, Minchington TG, Sutcliffe C, Upadhyai P, Rattray M, Ashe HL. Modulation of the Promoter Activation Rate Dictates the Transcriptional Response to Graded BMP Signaling Levels in the Drosophila Embryo. Developmental Cell 2020, 54: 727-741.e7. PMID: 32758422, PMCID: PMC7527239, DOI: 10.1016/j.devcel.2020.07.007.Peer-Reviewed Original ResearchConceptsDrosophila embryosCell fate decisionsMorphogen gradient interpretationTarget gene transcriptsSingle-cell resolutionBMP gradientMRNA outputAxis patterningCell fateExpression domainsTranscriptional responsePromoter sequencesGene transcriptsProtein gradientGradient interpretationBurst kineticsBMPEmbryosEnhancerClassic exampleCellsActivation rateMorphogensTranscriptsGeneral features