2020
Modulation of the Promoter Activation Rate Dictates the Transcriptional Response to Graded BMP Signaling Levels in the Drosophila Embryo
Hoppe C, Bowles JR, Minchington TG, Sutcliffe C, Upadhyai P, Rattray M, Ashe HL. Modulation of the Promoter Activation Rate Dictates the Transcriptional Response to Graded BMP Signaling Levels in the Drosophila Embryo. Developmental Cell 2020, 54: 727-741.e7. PMID: 32758422, PMCID: PMC7527239, DOI: 10.1016/j.devcel.2020.07.007.Peer-Reviewed Original ResearchConceptsDrosophila embryosCell fate decisionsMorphogen gradient interpretationTarget gene transcriptsSingle-cell resolutionBMP gradientMRNA outputAxis patterningCell fateExpression domainsTranscriptional responsePromoter sequencesGene transcriptsProtein gradientGradient interpretationBurst kineticsBMPEmbryosEnhancerClassic exampleCellsActivation rateMorphogensTranscriptsGeneral features
2013
The NHR-8 Nuclear Receptor Regulates Cholesterol and Bile Acid Homeostasis in C. elegans
Magner DB, Wollam J, Shen Y, Hoppe C, Li D, Latza C, Rottiers V, Hutter H, Antebi A. The NHR-8 Nuclear Receptor Regulates Cholesterol and Bile Acid Homeostasis in C. elegans. Cell Metabolism 2013, 18: 212-224. PMID: 23931753, PMCID: PMC3909615, DOI: 10.1016/j.cmet.2013.07.007.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsApolipoproteinsBile Acids and SaltsBiological TransportCaenorhabditis elegansCaenorhabditis elegans ProteinsCholestenesCholesterolFatty AcidsFertilityForkhead Transcription FactorsGene Expression RegulationHomeostasisLipid MetabolismLongevityMolecular Sequence DataOxygenasesReceptors, Cytoplasmic and NuclearSequence AlignmentSignal TransductionTranscription FactorsConceptsNuclear receptorsDAF-16/FOXOFatty acid desaturationCholesterol balanceDauer stageNHR-8Dafachronic acidTranscriptional regulatorsDevelopmental arrestNuclear receptor controlLiver XAcid homeostasisAcid metabolismUnregulated growthVitamin D receptorCholesterol availabilityReceptor controlEndocrine networkHomeostasisLife spanReproductionMetabolismBile acid homeostasisApolipoprotein productionImportant insights