2024
Cyclooxygenase 2 Inhibitors for Headache After Elective Cranial Neurosurgery: Results from a Systematic Review of Efficacy of Cyclooxygenase 2 Inhibitors for Headache After Acute Brain Injury
Comparan H, Khaliq A, Frota L, Pomar-Forero D, Ahmad B, Marnet E, Teixeira F, Thomas A, Patel P, Brunkal H, Singireddy S, Lucke-Wold B, Maciel C, Busl K. Cyclooxygenase 2 Inhibitors for Headache After Elective Cranial Neurosurgery: Results from a Systematic Review of Efficacy of Cyclooxygenase 2 Inhibitors for Headache After Acute Brain Injury. Neurocritical Care 2024, 1-10. PMID: 39266865, DOI: 10.1007/s12028-024-02114-y.Peer-Reviewed Original ResearchRationale and Design for the BLOCK-SAH Study (Pterygopalatine Fossa Block as an Opioid-Sparing Treatment for Acute Headache in Aneurysmal Subarachnoid Hemorrhage): A Phase II, Multicenter, Randomized, Double-Blinded, Placebo-Controlled Clinical Trial with a Sequential Parallel Comparison Design
Busl K, Smith C, Troxel A, Fava M, Illenberger N, Pop R, Yang W, Frota L, Gao H, Shan G, Hoh B, Maciel C. Rationale and Design for the BLOCK-SAH Study (Pterygopalatine Fossa Block as an Opioid-Sparing Treatment for Acute Headache in Aneurysmal Subarachnoid Hemorrhage): A Phase II, Multicenter, Randomized, Double-Blinded, Placebo-Controlled Clinical Trial with a Sequential Parallel Comparison Design. Neurocritical Care 2024, 1-11. PMID: 39138719, DOI: 10.1007/s12028-024-02078-z.Peer-Reviewed Original ResearchSequential parallel comparison designDouble-blindPain controlPterygopalatine fossaClinical trialsPlacebo-Controlled Clinical TrialPrimary tolerability end pointEnd pointsVerbal pain scoresEfficacy end pointOpen-label phaseTolerability end pointsPhase III trialsPost-subarachnoid hemorrhagePhase IIIII trialsPain scoresAcute headacheAneurysmal SAHSevere headachePeriprocedural monitoringPost-SAHHeadache phenotypeUltrasound guidanceAwake patientsLeveraging machine learning to develop a postoperative predictive model for postoperative urinary retention following lumbar spine surgery
Malnik S, Porche K, Mehkri Y, Yue S, Maciel C, Lucke-Wold B, Robicsek S, Decker M, Busl K. Leveraging machine learning to develop a postoperative predictive model for postoperative urinary retention following lumbar spine surgery. Frontiers In Neurology 2024, 15: 1386802. PMID: 38988605, PMCID: PMC11233696, DOI: 10.3389/fneur.2024.1386802.Peer-Reviewed Original ResearchPostoperative urinary retentionLumbar spine surgerySpine surgeryUrinary retentionPatient demographicsIncidence of postoperative urinary retentionRetrospective observational cohort studyTertiary academic medical centerIndwelling catheter placementIncreased patient morbidityReceiver operating characteristic curveArea under the receiver operating characteristic curveObservational cohort studyAcademic medical centerBody mass indexPostoperative prediction modelLogistic regression modelsIntraoperative variablesIntraoperative factorsCatheter placementAnesthesia variablesPatient morbidityMass indexSurgical proceduresCohort studyNeuro-oncologic Emergencies
Maciel C, Busl K. Neuro-oncologic Emergencies. CONTINUUM Lifelong Learning In Neurology 2024, 30: 845-877. PMID: 38830073, DOI: 10.1212/con.0000000000001435.Peer-Reviewed Original ResearchConceptsNeuro-oncologic emergenciesNeurological complicationsCentral nervous system malignanciesPrimary central nervous system malignancySystemic disease progressionTumor-specific characteristicsAcute neurologic complicationsNervous system malignanciesTreatment-resistant seizuresCSF flow dynamicsIntracranial burdenTumor-mediatedBrain metastasesImmunological therapiesNeuronal hyperexcitabilitySystem malignanciesTumor-relatedNeurotoxicity syndromeIntracranial hypertensionRisk stratificationFavorable outcomeTreatment-relatedSystem cancersDisease progressionComplicationsVerification of Death by Neurologic Criteria: A Survey of 12 Organ Procurement Organizations Across the United States
Sarhadi K, Hendershot K, Smith N, Souter M, Creutzfeldt C, Lele A, Maciel C, Busl K, Balogh J, Greer D, Lewis A, Wahlster S. Verification of Death by Neurologic Criteria: A Survey of 12 Organ Procurement Organizations Across the United States. Neurocritical Care 2024, 1-8. PMID: 38750393, DOI: 10.1007/s12028-024-02001-6.Peer-Reviewed Original ResearchOrgan procurement organizationsClinician knowledgeBackgroundThe Centers for MedicareReferral hospitalGuideline-concordant practicesAmerican AcademyCenters for MedicareMethodsAn electronic surveyMedical society guidelinesUnited StatesProcurement organizationsVerification of deathDetermine validityHospital policiesPractice parametersElectronic surveyAmerican Academy of Neurology practice parameterFederal lawAdvocacy effortsLegal requirementsReferralUS regionsPotential organ donorsNeurological CriteriaPublic trustA Spectrum, Not a Dichotomy for Seizure Foretelling—Learning to Identify Ominous Patterns and Understand the Pediatric Ictal-Interictal Continuum
Kincaid K, Maciel C. A Spectrum, Not a Dichotomy for Seizure Foretelling—Learning to Identify Ominous Patterns and Understand the Pediatric Ictal-Interictal Continuum. Neurocritical Care 2024, 1-2. PMID: 38671314, DOI: 10.1007/s12028-024-01991-7.Peer-Reviewed Original ResearchEfficacy of Cyclooxygenase-2 Inhibitors for Headache in Acute Brain Injury: A Systematic Review (P7-12.006)
Frota L, Khaliq A, Comparan H, Pomar-Forero D, Ahmad B, Maciel C, Busl K. Efficacy of Cyclooxygenase-2 Inhibitors for Headache in Acute Brain Injury: A Systematic Review (P7-12.006). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000206229.Peer-Reviewed Original ResearchSurvey of Nationwide Organ Procurement Organization (OPO) Practices in Verification of Death by Neurologic Criteria (DNC) (P1-2.001)
Sarhadi K, Hendershot K, Smith N, Souter M, Creutzfeldt C, Lele A, Maciel C, Balogh J, Greer D, Busl K, Lewis A, Wahlster S. Survey of Nationwide Organ Procurement Organization (OPO) Practices in Verification of Death by Neurologic Criteria (DNC) (P1-2.001). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000205433.Peer-Reviewed Original ResearchVIGAB-STAT—A Phase IIa Feasibility Trial of Irreversible GABA-transaminase Inhibition as Adjunct Treatment of Status Epilepticus After Cardiac Arrest (P4-2.003)
Ahmad B, Maranchick N, Pomar-Forero D, Busl K, Hirsch L, Bruzzone M, Eisenschenk S, Peloquin C, Maciel C. VIGAB-STAT—A Phase IIa Feasibility Trial of Irreversible GABA-transaminase Inhibition as Adjunct Treatment of Status Epilepticus After Cardiac Arrest (P4-2.003). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000205180.Peer-Reviewed Original ResearchDeath Foretold: Are We Truly Improving Outcome Prediction After Cardiac Arrest or Nurturing Self-Fulfilling Prophecies?*
Maciel C, Busl K, Elmer J. Death Foretold: Are We Truly Improving Outcome Prediction After Cardiac Arrest or Nurturing Self-Fulfilling Prophecies?*. Critical Care Medicine 2024, 52: 656-659. PMID: 38483220, DOI: 10.1097/ccm.0000000000006149.Peer-Reviewed Original ResearchConceptsSelf-fulfilling prophecyIn search of simplicity for a complicated matter—a creative step forward, but still falling short in the early prediction of the hypoxic-ischemic spiraling of death
Busl K, Maciel C. In search of simplicity for a complicated matter—a creative step forward, but still falling short in the early prediction of the hypoxic-ischemic spiraling of death. Resuscitation 2024, 195: 110118. PMID: 38220063, DOI: 10.1016/j.resuscitation.2024.110118.Peer-Reviewed Original Research
2023
Wolf Creek XVII part 9: Wolf Creek Innovator in Cardiac Arrest and Resuscitation Science Award
Gottula A, Maciel C, Nishikimi M, Kalra R, Sunshine J, Morgan R. Wolf Creek XVII part 9: Wolf Creek Innovator in Cardiac Arrest and Resuscitation Science Award. Resuscitation Plus 2023, 17: 100519. PMID: 38076386, PMCID: PMC10698667, DOI: 10.1016/j.resplu.2023.100519.Peer-Reviewed Original ResearchSurvivorship after post-anoxic cerebral hyperexcitability requires more than functional independence
Elmer J, Maciel C. Survivorship after post-anoxic cerebral hyperexcitability requires more than functional independence. Resuscitation 2023, 189: 109866. PMID: 37302685, DOI: 10.1016/j.resuscitation.2023.109866.Peer-Reviewed Original ResearchDiscrepancies Between Neuroprognostication Assessments and End-of-Life Decision-Making in Post-Cardiac Arrest Patients (S4.002)
Rubenstein A, Stafford R, Scott A, Maciel C, Silva G, Beekman R, Gilmore E, Greer D. Discrepancies Between Neuroprognostication Assessments and End-of-Life Decision-Making in Post-Cardiac Arrest Patients (S4.002). Neurology 2023, 100 DOI: 10.1212/wnl.0000000000203933.Peer-Reviewed Original Research
2022
Severe Headache Trajectory Following Aneurysmal Subarachnoid Hemorrhage: The Association with Lower Sodium Levels (P1-1.Virtual)
Eisinger R, Sorrentino Z, Lucke-Wold B, Zhou S, Barlow B, Hoh B, Maciel C, Busl K. Severe Headache Trajectory Following Aneurysmal Subarachnoid Hemorrhage: The Association with Lower Sodium Levels (P1-1.Virtual). Neurology 2022, 98 DOI: 10.1212/wnl.98.18_supplement.1699.Peer-Reviewed Original ResearchClinical Correlates of Cyclic Alternating Pattern of Encephalopathy (CAPE) (P15-8.004)
Yu C, Smith C, Parker T, Landvay K, Hu C, Eisenschenk S, Wang Y, Bruzzone M, Maciel C. Clinical Correlates of Cyclic Alternating Pattern of Encephalopathy (CAPE) (P15-8.004). Neurology 2022, 98 DOI: 10.1212/wnl.98.18_supplement.997.Peer-Reviewed Original ResearchCombining Machine-detected EEG Epileptiform Abnormalities and Quantitative EEG Spectral Features Predicts Post Traumatic Epilepsy (S7.002)
Chen Y, Li S, Chen H, Doherty D, Herman A, Kaleem S, Ding K, Osman G, Swisher C, Smith C, Maciel C, Alkhachroum A, Lee J, Dhakar M, Gilmore E, Omay S, Edlow B, Westover M, Kim J. Combining Machine-detected EEG Epileptiform Abnormalities and Quantitative EEG Spectral Features Predicts Post Traumatic Epilepsy (S7.002). Neurology 2022, 98 DOI: 10.1212/wnl.98.18_supplement.3034.Peer-Reviewed Original Research
2021
Perioperative Practices of Moyamoya Syndrome Undergoing Revascularization (4680)
Eckert M, Bhakta N, Babi M, Busl K, Cohen S, Gatica S, Robicsek S, Robinson C, Roth W, Trippensee A, Mohammed B, Maciel C. Perioperative Practices of Moyamoya Syndrome Undergoing Revascularization (4680). Neurology 2021, 96 DOI: 10.1212/wnl.96.15_supplement.4680.Peer-Reviewed Original Research5-Fluorouracil Neurotoxicity in Patient Without Dihydropyrimidine Dehydrogenase Deficiency (4729)
Jules R, Maciel C, Busl K, Ameli P, Robinson C, Babi M, Roth W. 5-Fluorouracil Neurotoxicity in Patient Without Dihydropyrimidine Dehydrogenase Deficiency (4729). Neurology 2021, 96 DOI: 10.1212/wnl.96.15_supplement.4729.Peer-Reviewed Original ResearchOral Pregabalin As Adjunctive Treatment For Symptomatic Cyclic Seizures In Neurocritically Ill Patients (4740)
Patel M, Newcomer Z, Cohen S, JADAV R, Fong M, Mitropanopoulos S, Bruzzone M, Busl K, Maciel C. Oral Pregabalin As Adjunctive Treatment For Symptomatic Cyclic Seizures In Neurocritically Ill Patients (4740). Neurology 2021, 96 DOI: 10.1212/wnl.96.15_supplement.4740.Peer-Reviewed Original Research