Cyclooxygenase 2 Inhibitors for Headache After Elective Cranial Neurosurgery: Results from a Systematic Review of Efficacy of Cyclooxygenase 2 Inhibitors for Headache After Acute Brain Injury
Comparan H, Khaliq A, Frota L, Pomar-Forero D, Ahmad B, Marnet E, Teixeira F, Thomas A, Patel P, Brunkal H, Singireddy S, Lucke-Wold B, Maciel C, Busl K. Cyclooxygenase 2 Inhibitors for Headache After Elective Cranial Neurosurgery: Results from a Systematic Review of Efficacy of Cyclooxygenase 2 Inhibitors for Headache After Acute Brain Injury. Neurocritical Care 2024, 1-10. PMID: 39266865, DOI: 10.1007/s12028-024-02114-y.Peer-Reviewed Original ResearchIntervention groupSystematic reviewHeadache managementCyclooxygenase 2 inhibitorsAcute brain injuryElective cranial neurosurgeryPain scoresRandomized controlled trialsHospital length of stayRetrospective cohort studyLength of stayModerate to mild severityBrain injuryIndependent reviewersDescriptive statisticsCohort studyStudy heterogeneityInclusion criteriaControlled trialsArticle selectionObservational studyInterventionMeta-analysisElective cranial surgeryHospital lengthRationale and Design for the BLOCK-SAH Study (Pterygopalatine Fossa Block as an Opioid-Sparing Treatment for Acute Headache in Aneurysmal Subarachnoid Hemorrhage): A Phase II, Multicenter, Randomized, Double-Blinded, Placebo-Controlled Clinical Trial with a Sequential Parallel Comparison Design
Busl K, Smith C, Troxel A, Fava M, Illenberger N, Pop R, Yang W, Frota L, Gao H, Shan G, Hoh B, Maciel C. Rationale and Design for the BLOCK-SAH Study (Pterygopalatine Fossa Block as an Opioid-Sparing Treatment for Acute Headache in Aneurysmal Subarachnoid Hemorrhage): A Phase II, Multicenter, Randomized, Double-Blinded, Placebo-Controlled Clinical Trial with a Sequential Parallel Comparison Design. Neurocritical Care 2024, 1-11. PMID: 39138719, DOI: 10.1007/s12028-024-02078-z.Peer-Reviewed Original ResearchSequential parallel comparison designDouble-blindPain controlPterygopalatine fossaClinical trialsPlacebo-Controlled Clinical TrialPrimary tolerability end pointEnd pointsVerbal pain scoresEfficacy end pointOpen-label phaseTolerability end pointsPhase III trialsPost-subarachnoid hemorrhagePhase IIIII trialsPain scoresAcute headacheAneurysmal SAHSevere headachePeriprocedural monitoringPost-SAHHeadache phenotypeUltrasound guidanceAwake patients