2023
Naltrexone/bupropion for binge‐eating disorder: A randomized, double‐blind, placebo‐controlled trial
Grilo C, Lydecker J, Jastreboff A, Pittman B, McKee S. Naltrexone/bupropion for binge‐eating disorder: A randomized, double‐blind, placebo‐controlled trial. Obesity 2023, 31: 2762-2773. PMID: 37751990, PMCID: PMC10600891, DOI: 10.1002/oby.23898.Peer-Reviewed Original ResearchConceptsNaltrexone/bupropionBinge-eating disorderObesity statusLogistic regressionWeight lossPlacebo-controlled trialWeight loss outcomesPrevalent psychiatric disordersEvidence-based treatmentsPost-treatment assessmentBinge-eating frequencyGreater percentage weight lossMedication outcomesRemission ratePharmacological optionsPlaceboBupropionPsychiatric disordersPercentage weight lossMixed modelsDisordersObesityPatientsSignificant reductionWeight reductionImprovements in cardiovascular disease risk factors associated with modest weight loss following treatment in patients with binge‐eating disorder and obesity
Yurkow S, Ivezaj V, Grilo C. Improvements in cardiovascular disease risk factors associated with modest weight loss following treatment in patients with binge‐eating disorder and obesity. International Journal Of Eating Disorders 2023, 56: 2074-2083. PMID: 37530200, PMCID: PMC10834830, DOI: 10.1002/eat.24035.Peer-Reviewed Original ResearchConceptsCardiovascular disease risk factorsModest weight lossDisease risk factorsBinge-eating disorderPlasma glucoseRisk factorsWeight lossLifestyle changesBehavioral lifestyle changesCardiovascular disease riskWeight loss treatmentSignificant improvementRelated lifestyle changesTotal cholesterolPotential health benefitsHeart ratePatientsObesityDisease riskHbA1cHealth benefitsDisordersTriglyceridesTreatmentPosttreatmentBinge-Eating Disorder Interventions: Review, Current Status, and Implications
Grilo C, Juarascio A. Binge-Eating Disorder Interventions: Review, Current Status, and Implications. Current Obesity Reports 2023, 12: 406-416. PMID: 37439970, PMCID: PMC10528223, DOI: 10.1007/s13679-023-00517-0.Peer-Reviewed Original ResearchConceptsPsychological treatmentSpecific psychological treatmentsEating-disorder psychopathologyEvidence-based treatmentsAdditional pharmacological optionsDisorder interventionsSerious psychiatric problemsBehavioral lifestyle interventionScalable interventionsEffective interventionsFuture researchCBTPsychiatric problemsBingeMixed outcomesInterventionCBTgshModest weight lossRecent findingsResearchPsychopathologyShameLifestyle interventionPharmacological optionsSubstantial morbidityNaltrexone plus bupropion combination medication maintenance treatment for binge-eating disorder following successful acute treatments: randomized double-blind placebo-controlled trial
Grilo C, Lydecker J, Gueorguieva R. Naltrexone plus bupropion combination medication maintenance treatment for binge-eating disorder following successful acute treatments: randomized double-blind placebo-controlled trial. Psychological Medicine 2023, 53: 7775-7784. PMID: 37366017, PMCID: PMC10751383, DOI: 10.1017/s0033291723001800.Peer-Reviewed Original ResearchConceptsNaltrexone/bupropionBinge-eating disorderBinge-eating remissionAcute treatmentMaintenance treatmentBinge-eating frequencyDouble-blind placebo-controlled trialBehavioral weight loss therapyWeight lossCo-occurring obesitySuccessful acute treatmentPlacebo-controlled trialWeight loss therapySignificant additional weight lossSingle-site trialAdditional weight lossAcute efficacyRemission rateAdult patientsComorbid obesityBupropionInitial interventionPosttreatment assessmentRespondersPlaceboPredictors of early weight loss in post‐bariatric surgery patients receiving adjunctive behavioural treatments for loss‐of‐control eating
Smith C, Dilip A, Ivezaj V, Duffy A, Grilo C. Predictors of early weight loss in post‐bariatric surgery patients receiving adjunctive behavioural treatments for loss‐of‐control eating. Clinical Obesity 2023, 13: e12603. PMID: 37257889, PMCID: PMC10524670, DOI: 10.1111/cob.12603.Peer-Reviewed Original ResearchConceptsEarly weight lossAdjunctive behavioral treatmentsPost-bariatric surgery patientsEarly weight changeBaseline patient characteristicsSurgery-related variablesMonths of treatmentWeight lossBehavioral treatmentPatient characteristicsSurgery patientsFirst monthWeight changeTime of surgeryWeight gain groupEating-disorder psychopathologyBariatric surgeryMost patientsAdjunctive treatmentBlack patientsPercent weight lossPsychiatric comorbidityClinical variablesTreatment trialsPatientsCognitive‐behavioral therapy for binge‐eating disorder for non‐responders to initial acute treatments: Randomized controlled trial
Grilo C, Lydecker J, Gueorguieva R. Cognitive‐behavioral therapy for binge‐eating disorder for non‐responders to initial acute treatments: Randomized controlled trial. International Journal Of Eating Disorders 2023, 56: 1544-1553. PMID: 37144325, PMCID: PMC10524840, DOI: 10.1002/eat.23975.Peer-Reviewed Original ResearchConceptsInitial acute treatmentBinge-eating disorderCognitive behavioral therapyAcute treatmentBinge-eating frequencyInitial interventionTherapist-led cognitive behavioural therapyInitial pharmacological treatmentTreat remission ratesEvidence-based treatmentsSingle-site trialAcute efficacyRemission rateAdult patientsInitial treatmentPharmacological treatmentPatientsPosttreatment assessmentBehavioral treatmentSufficient benefitTherapyDisordersInterventionTreatmentPharmacotherapyLoss of control in binge‐eating disorder: Fear and resignation
Perelman H, Gilbert K, Grilo C, Lydecker J. Loss of control in binge‐eating disorder: Fear and resignation. International Journal Of Eating Disorders 2023, 56: 1199-1206. PMID: 36920120, PMCID: PMC10247475, DOI: 10.1002/eat.23929.Peer-Reviewed Original ResearchConceptsBinge-eating disorderCognitive-affective experiencesLoss of controlModerate treatment outcomeBinge-eating episodesEating-disorder psychopathologyTreatment-seeking patientsFuture researchAbsence of fearGreater distressPsychopathologyFearSevere psychopathologyResearch cliniciansSemistructured interviewsTreatment formulationPast monthDisordersResignationTreatment outcomesExperienceBlack individualsEmotionsTreatment planningIndividualsPsychiatric comorbidity as a prospective predictor of long-term weight and psychosocial outcomes after bariatric surgery
Ivezaj V, Dilip A, Grilo C. Psychiatric comorbidity as a prospective predictor of long-term weight and psychosocial outcomes after bariatric surgery. General Hospital Psychiatry 2023, 83: 51-58. PMID: 37099869, DOI: 10.1016/j.genhosppsych.2023.03.005.Peer-Reviewed Original ResearchConceptsEating Disorder Examination-Bariatric Surgery VersionLong-term weight outcomesPost-bariatric surgeryPsychiatric comorbidityEating-disorder psychopathologyBariatric surgeryWeight outcomesMonths post-bariatric surgeryMini International Neuropsychiatric InterviewWeight loss outcomesCurrent psychiatric disorderCurrent psychiatric comorbidityInternational Neuropsychiatric InterviewPsychosocial functioning outcomesLong-term weightBeck Depression InventoryPoor psychosocial functioningPrognostic significanceProspective studyBariatric populationNeuropsychiatric InterviewClinical significanceComorbiditiesLoss outcomesPsychiatric disordersPredictors and significance of rapid response to behaviorally based treatment of binge eating disorder
Yurkow S, Ivezaj V, Grilo C. Predictors and significance of rapid response to behaviorally based treatment of binge eating disorder. Obesity 2023, 31: 390-398. PMID: 36623872, PMCID: PMC9877118, DOI: 10.1002/oby.23648.Peer-Reviewed Original ResearchConceptsDemographic featuresTreatment attitudesWeight lossFourth treatment weekWeight loss outcomesPsychiatric variablesSuperior clinical outcomesWeight loss treatmentTreatment of bingeClinical severity variablesClinical outcomesPrognostic significanceTreatment weekClinical trialsBaseline predictorsLoss outcomesLoss treatmentPosttreatment outcomesBinge eatingIndependent assessorsBingeSeverity variablesDisordersPatientsTreatment
2022
Examining changes in binge‐eating disorder network centrality and structure in patients treated with cognitive‐behavioral therapy versus interpersonal psychotherapy
Forrest L, Franko D, Thompson‐Brenner H, Grilo C. Examining changes in binge‐eating disorder network centrality and structure in patients treated with cognitive‐behavioral therapy versus interpersonal psychotherapy. International Journal Of Eating Disorders 2022, 56: 944-955. PMID: 36565241, PMCID: PMC10159900, DOI: 10.1002/eat.23883.Peer-Reviewed Original ResearchConceptsBinge-eating disorderCognitive behavioral therapyEvidence-based treatmentsInterpersonal psychotherapyIntervention targetsBinge-eating disorder symptomsBehavioral therapyIndicator of remissionShape concernsRefinement of treatmentClinical utilityFrequent associationClinical implicationsSymptomsSymptom interactionsTherapyInterpersonal therapyWeight concernsDisorder symptomsSymptom relationshipsDisordersPatientsTreatmentSizeable minorityNetwork of symptomsFactor structure and measurement invariance of the English- versus Spanish-language Eating Disorder Examination Questionnaire: Brief Form (S-EDE-Q-BF) in Hispanic/Latino/a/x persons seeking bariatric surgery
Marek R, Ivezaj V, Parikh M, Jayade M, Davila-Shiau E, Grilo C. Factor structure and measurement invariance of the English- versus Spanish-language Eating Disorder Examination Questionnaire: Brief Form (S-EDE-Q-BF) in Hispanic/Latino/a/x persons seeking bariatric surgery. Surgery For Obesity And Related Diseases 2022, 19: 576-584. PMID: 36639321, DOI: 10.1016/j.soard.2022.12.015.Peer-Reviewed Original Research
2018
Loss-of-control eating after bariatric/sleeve gastrectomy surgery: Similar to binge-eating disorder despite differences in quantities
Ivezaj V, Barnes RD, Cooper Z, Grilo CM. Loss-of-control eating after bariatric/sleeve gastrectomy surgery: Similar to binge-eating disorder despite differences in quantities. General Hospital Psychiatry 2018, 54: 25-30. PMID: 30056316, PMCID: PMC6245943, DOI: 10.1016/j.genhosppsych.2018.07.002.Peer-Reviewed Original ResearchConceptsSleeve gastrectomy surgeryBinge-eating disorderGastrectomy surgeryBinge Eating DisorderClinical featuresPatient groupControl eatingOW/OBOverweight/obesityBody mass indexRelevant patient groupsMass indexDepressive symptomsSurgeryPast monthBED groupWeight concernsWeekly lossDisordersCareful assessmentObesityOnly groupQuantity of foodComparable levelsEatingFood addiction among men and women in India
Wiedemann AA, Lawson JL, Cunningham PM, Khalvati KM, Lydecker JA, Ivezaj V, Grilo CM. Food addiction among men and women in India. European Eating Disorders Review 2018, 26: 597-604. PMID: 30003654, PMCID: PMC6261447, DOI: 10.1002/erv.2613.Peer-Reviewed Original ResearchConceptsHealth-related qualityBody mass indexHigher severity scoresEating-disorder psychopathologyClinical featuresMass indexSF-12Severity scoreClinical thresholdFood addictionEDE-Q subscalesYFAS scoresHigher depressionGreater frequencyYFASScoresNonclinical groupSelf-report measuresWomenDepressionMenFood addiction among Spanish-speaking Latino/as residing in the United States
Ivezaj V, Wiedemann AA, Lydecker JA, Grilo CM. Food addiction among Spanish-speaking Latino/as residing in the United States. Eating Behaviors 2018, 30: 61-65. PMID: 29870970, PMCID: PMC6047914, DOI: 10.1016/j.eatbeh.2018.05.009.Peer-Reviewed Original ResearchConceptsBody mass indexYale Food Addiction ScaleFood addictionDepressive symptomsPoorer overall mental healthClinical levelYFAS scoresHigher YFAS scoresEating-disorder psychopathologyAnonymous web-based surveyFood addiction symptomsOverall mental healthMass indexMean ageSF-12PHQ-2Physical functioningWeb-based surveyClinical thresholdParticipant groupsAssociated psychopathologyMental healthSimilar findingsSymptomsWeight/shapeParents have both implicit and explicit biases against children with obesity
Lydecker JA, O’Brien E, Grilo CM. Parents have both implicit and explicit biases against children with obesity. Journal Of Behavioral Medicine 2018, 41: 784-791. PMID: 29728951, PMCID: PMC6209524, DOI: 10.1007/s10865-018-9929-4.Peer-Reviewed Original ResearchConceptsImplicit weight biasWeight biasChild variablesExplicit biasChild psychosocial functioningExplicit weight biasExplicit biasesChildren's resiliencePsychosocial functioningStigmatizing environmentsImplicit biasOverweight/obesityWeight discriminationParentsChildrenBiasResilienceChild healthObesityFunctioningClinical researchYouthBiasesHealthLess biasPrevalence and Correlates of DSM-5–Defined Eating Disorders in a Nationally Representative Sample of U.S. Adults
Udo T, Grilo CM. Prevalence and Correlates of DSM-5–Defined Eating Disorders in a Nationally Representative Sample of U.S. Adults. Biological Psychiatry 2018, 84: 345-354. PMID: 29859631, PMCID: PMC6097933, DOI: 10.1016/j.biopsych.2018.03.014.Peer-Reviewed Original ResearchEarly weight loss predicts weight loss treatment response regardless of binge‐eating disorder status and pretreatment weight change
Barnes RD, Ivezaj V, Pittman BP, Grilo CM. Early weight loss predicts weight loss treatment response regardless of binge‐eating disorder status and pretreatment weight change. International Journal Of Eating Disorders 2018, 51: 558-564. PMID: 29637592, PMCID: PMC6002900, DOI: 10.1002/eat.22860.Peer-Reviewed Original ResearchConceptsEarly weight lossWeight loss treatmentBinge-eating disorderLoss treatmentWeight lossBed statusWeight loss treatment outcomesOverweight/obesityWeight loss trialAverage weight lossWeight-related variablesPrognostic significancePrimary careTreatment outcomesTreatment responseLoss trialWeight trajectoriesTreatment studiesDisorder statusWeight changeOutcomesTreatmentIndividual responsesStatusPositive outcomesAssociations of parents' self, child, and other “fat talk” with child eating behaviors and weight
Lydecker JA, Riley KE, Grilo CM. Associations of parents' self, child, and other “fat talk” with child eating behaviors and weight. International Journal Of Eating Disorders 2018, 51: 527-534. PMID: 29542177, PMCID: PMC6002914, DOI: 10.1002/eat.22858.Peer-Reviewed Original ResearchConceptsFat talkParents of preadolescentsParents' selfChildren's eatingChild sexSecretive eatingNegative communicationWeight-related interventionsFront of childrenAdolescent girlsPeer groupEatingPreadolescentsParentsSelfAdolescentsChildrenDifferent formsTalkWeight variablesBehaviorOverweight/obesityAssociationGirlsInterventionComparing men and women with binge‐eating disorder and co‐morbid obesity
Lydecker JA, Grilo CM. Comparing men and women with binge‐eating disorder and co‐morbid obesity. International Journal Of Eating Disorders 2018, 51: 411-417. PMID: 29493793, PMCID: PMC5980708, DOI: 10.1002/eat.22847.Peer-Reviewed Original ResearchConceptsBody mass indexBinge-eating disorderEating-disorder psychopathologyBinge-eating episodesBinge-eating behaviorClinical presentationResearch cliniciansHigher body mass indexCo-morbid obesityDSM-IV disordersStructured Clinical InterviewEating Disorder Examination interviewAge of onsetBinge-eating frequencyRace/ethnicityMass indexBED diagnosisClinical InterviewYounger ageObesityExamination interviewWomenMenAgeDisorders
2017
Driven exercise in the absence of binge eating: Implications for purging disorder
Lydecker JA, Shea M, Grilo CM. Driven exercise in the absence of binge eating: Implications for purging disorder. International Journal Of Eating Disorders 2017, 51: 139-145. PMID: 29215743, PMCID: PMC5796839, DOI: 10.1002/eat.22811.Peer-Reviewed Original ResearchConceptsEating-disorder psychopathologyClinical significancePhysical activityCompensatory behaviorsBinge-eating episodesAbsence of bingeEating Disorder PsychopathologyLower depression levelsLow-frequency thresholdsWeb-based surveyDepression levelsSmall sample sizeHigher depressionOverall frequencyLaxativesTreatment researchMost domainsExerciseBingePsychopathologyDisordersDepressionParticipantsSimilar levelsFurther support