2023
Naltrexone/bupropion for binge‐eating disorder: A randomized, double‐blind, placebo‐controlled trial
Grilo C, Lydecker J, Jastreboff A, Pittman B, McKee S. Naltrexone/bupropion for binge‐eating disorder: A randomized, double‐blind, placebo‐controlled trial. Obesity 2023, 31: 2762-2773. PMID: 37751990, PMCID: PMC10600891, DOI: 10.1002/oby.23898.Peer-Reviewed Original ResearchConceptsNaltrexone/bupropionBinge-eating disorderObesity statusLogistic regressionWeight lossPlacebo-controlled trialWeight loss outcomesPrevalent psychiatric disordersEvidence-based treatmentsPost-treatment assessmentBinge-eating frequencyGreater percentage weight lossMedication outcomesRemission ratePharmacological optionsPlaceboBupropionPsychiatric disordersPercentage weight lossMixed modelsDisordersObesityPatientsSignificant reductionWeight reductionNaltrexone plus bupropion combination medication maintenance treatment for binge-eating disorder following successful acute treatments: randomized double-blind placebo-controlled trial
Grilo C, Lydecker J, Gueorguieva R. Naltrexone plus bupropion combination medication maintenance treatment for binge-eating disorder following successful acute treatments: randomized double-blind placebo-controlled trial. Psychological Medicine 2023, 53: 7775-7784. PMID: 37366017, PMCID: PMC10751383, DOI: 10.1017/s0033291723001800.Peer-Reviewed Original ResearchConceptsNaltrexone/bupropionBinge-eating disorderBinge-eating remissionAcute treatmentMaintenance treatmentBinge-eating frequencyDouble-blind placebo-controlled trialBehavioral weight loss therapyWeight lossCo-occurring obesitySuccessful acute treatmentPlacebo-controlled trialWeight loss therapySignificant additional weight lossSingle-site trialAdditional weight lossAcute efficacyRemission rateAdult patientsComorbid obesityBupropionInitial interventionPosttreatment assessmentRespondersPlaceboCognitive‐behavioral therapy for binge‐eating disorder for non‐responders to initial acute treatments: Randomized controlled trial
Grilo C, Lydecker J, Gueorguieva R. Cognitive‐behavioral therapy for binge‐eating disorder for non‐responders to initial acute treatments: Randomized controlled trial. International Journal Of Eating Disorders 2023, 56: 1544-1553. PMID: 37144325, PMCID: PMC10524840, DOI: 10.1002/eat.23975.Peer-Reviewed Original ResearchConceptsInitial acute treatmentBinge-eating disorderCognitive behavioral therapyAcute treatmentBinge-eating frequencyInitial interventionTherapist-led cognitive behavioural therapyInitial pharmacological treatmentTreat remission ratesEvidence-based treatmentsSingle-site trialAcute efficacyRemission rateAdult patientsInitial treatmentPharmacological treatmentPatientsPosttreatment assessmentBehavioral treatmentSufficient benefitTherapyDisordersInterventionTreatmentPharmacotherapy
2022
Examining changes in binge‐eating disorder network centrality and structure in patients treated with cognitive‐behavioral therapy versus interpersonal psychotherapy
Forrest L, Franko D, Thompson‐Brenner H, Grilo C. Examining changes in binge‐eating disorder network centrality and structure in patients treated with cognitive‐behavioral therapy versus interpersonal psychotherapy. International Journal Of Eating Disorders 2022, 56: 944-955. PMID: 36565241, PMCID: PMC10159900, DOI: 10.1002/eat.23883.Peer-Reviewed Original ResearchConceptsBinge-eating disorderCognitive behavioral therapyEvidence-based treatmentsInterpersonal psychotherapyIntervention targetsBinge-eating disorder symptomsBehavioral therapyIndicator of remissionShape concernsRefinement of treatmentClinical utilityFrequent associationClinical implicationsSymptomsSymptom interactionsTherapyInterpersonal therapyWeight concernsDisorder symptomsSymptom relationshipsDisordersPatientsTreatmentSizeable minorityNetwork of symptomsFactor structure and measurement invariance of the English- versus Spanish-language Eating Disorder Examination Questionnaire: Brief Form (S-EDE-Q-BF) in Hispanic/Latino/a/x persons seeking bariatric surgery
Marek R, Ivezaj V, Parikh M, Jayade M, Davila-Shiau E, Grilo C. Factor structure and measurement invariance of the English- versus Spanish-language Eating Disorder Examination Questionnaire: Brief Form (S-EDE-Q-BF) in Hispanic/Latino/a/x persons seeking bariatric surgery. Surgery For Obesity And Related Diseases 2022, 19: 576-584. PMID: 36639321, DOI: 10.1016/j.soard.2022.12.015.Peer-Reviewed Original Research
2018
Loss-of-control eating after bariatric/sleeve gastrectomy surgery: Similar to binge-eating disorder despite differences in quantities
Ivezaj V, Barnes RD, Cooper Z, Grilo CM. Loss-of-control eating after bariatric/sleeve gastrectomy surgery: Similar to binge-eating disorder despite differences in quantities. General Hospital Psychiatry 2018, 54: 25-30. PMID: 30056316, PMCID: PMC6245943, DOI: 10.1016/j.genhosppsych.2018.07.002.Peer-Reviewed Original ResearchConceptsSleeve gastrectomy surgeryBinge-eating disorderGastrectomy surgeryBinge Eating DisorderClinical featuresPatient groupControl eatingOW/OBOverweight/obesityBody mass indexRelevant patient groupsMass indexDepressive symptomsSurgeryPast monthBED groupWeight concernsWeekly lossDisordersCareful assessmentObesityOnly groupQuantity of foodComparable levelsEatingFood addiction among men and women in India
Wiedemann AA, Lawson JL, Cunningham PM, Khalvati KM, Lydecker JA, Ivezaj V, Grilo CM. Food addiction among men and women in India. European Eating Disorders Review 2018, 26: 597-604. PMID: 30003654, PMCID: PMC6261447, DOI: 10.1002/erv.2613.Peer-Reviewed Original ResearchConceptsHealth-related qualityBody mass indexHigher severity scoresEating-disorder psychopathologyClinical featuresMass indexSF-12Severity scoreClinical thresholdFood addictionEDE-Q subscalesYFAS scoresHigher depressionGreater frequencyYFASScoresNonclinical groupSelf-report measuresWomenDepressionMenFood addiction among Spanish-speaking Latino/as residing in the United States
Ivezaj V, Wiedemann AA, Lydecker JA, Grilo CM. Food addiction among Spanish-speaking Latino/as residing in the United States. Eating Behaviors 2018, 30: 61-65. PMID: 29870970, PMCID: PMC6047914, DOI: 10.1016/j.eatbeh.2018.05.009.Peer-Reviewed Original ResearchConceptsBody mass indexYale Food Addiction ScaleFood addictionDepressive symptomsPoorer overall mental healthClinical levelYFAS scoresHigher YFAS scoresEating-disorder psychopathologyAnonymous web-based surveyFood addiction symptomsOverall mental healthMass indexMean ageSF-12PHQ-2Physical functioningWeb-based surveyClinical thresholdParticipant groupsAssociated psychopathologyMental healthSimilar findingsSymptomsWeight/shapeParents have both implicit and explicit biases against children with obesity
Lydecker JA, O’Brien E, Grilo CM. Parents have both implicit and explicit biases against children with obesity. Journal Of Behavioral Medicine 2018, 41: 784-791. PMID: 29728951, PMCID: PMC6209524, DOI: 10.1007/s10865-018-9929-4.Peer-Reviewed Original ResearchConceptsImplicit weight biasWeight biasChild variablesExplicit biasChild psychosocial functioningExplicit weight biasExplicit biasesChildren's resiliencePsychosocial functioningStigmatizing environmentsImplicit biasOverweight/obesityWeight discriminationParentsChildrenBiasResilienceChild healthObesityFunctioningClinical researchYouthBiasesHealthLess biasPrevalence and Correlates of DSM-5–Defined Eating Disorders in a Nationally Representative Sample of U.S. Adults
Udo T, Grilo CM. Prevalence and Correlates of DSM-5–Defined Eating Disorders in a Nationally Representative Sample of U.S. Adults. Biological Psychiatry 2018, 84: 345-354. PMID: 29859631, PMCID: PMC6097933, DOI: 10.1016/j.biopsych.2018.03.014.Peer-Reviewed Original ResearchEarly weight loss predicts weight loss treatment response regardless of binge‐eating disorder status and pretreatment weight change
Barnes RD, Ivezaj V, Pittman BP, Grilo CM. Early weight loss predicts weight loss treatment response regardless of binge‐eating disorder status and pretreatment weight change. International Journal Of Eating Disorders 2018, 51: 558-564. PMID: 29637592, PMCID: PMC6002900, DOI: 10.1002/eat.22860.Peer-Reviewed Original ResearchConceptsEarly weight lossWeight loss treatmentBinge-eating disorderLoss treatmentWeight lossBed statusWeight loss treatment outcomesOverweight/obesityWeight loss trialAverage weight lossWeight-related variablesPrognostic significancePrimary careTreatment outcomesTreatment responseLoss trialWeight trajectoriesTreatment studiesDisorder statusWeight changeOutcomesTreatmentIndividual responsesStatusPositive outcomesAssociations of parents' self, child, and other “fat talk” with child eating behaviors and weight
Lydecker JA, Riley KE, Grilo CM. Associations of parents' self, child, and other “fat talk” with child eating behaviors and weight. International Journal Of Eating Disorders 2018, 51: 527-534. PMID: 29542177, PMCID: PMC6002914, DOI: 10.1002/eat.22858.Peer-Reviewed Original ResearchConceptsFat talkParents of preadolescentsParents' selfChildren's eatingChild sexSecretive eatingNegative communicationWeight-related interventionsFront of childrenAdolescent girlsPeer groupEatingPreadolescentsParentsSelfAdolescentsChildrenDifferent formsTalkWeight variablesBehaviorOverweight/obesityAssociationGirlsInterventionComparing men and women with binge‐eating disorder and co‐morbid obesity
Lydecker JA, Grilo CM. Comparing men and women with binge‐eating disorder and co‐morbid obesity. International Journal Of Eating Disorders 2018, 51: 411-417. PMID: 29493793, PMCID: PMC5980708, DOI: 10.1002/eat.22847.Peer-Reviewed Original ResearchConceptsBody mass indexBinge-eating disorderEating-disorder psychopathologyBinge-eating episodesBinge-eating behaviorClinical presentationResearch cliniciansHigher body mass indexCo-morbid obesityDSM-IV disordersStructured Clinical InterviewEating Disorder Examination interviewAge of onsetBinge-eating frequencyRace/ethnicityMass indexBED diagnosisClinical InterviewYounger ageObesityExamination interviewWomenMenAgeDisorders
2017
Driven exercise in the absence of binge eating: Implications for purging disorder
Lydecker JA, Shea M, Grilo CM. Driven exercise in the absence of binge eating: Implications for purging disorder. International Journal Of Eating Disorders 2017, 51: 139-145. PMID: 29215743, PMCID: PMC5796839, DOI: 10.1002/eat.22811.Peer-Reviewed Original ResearchConceptsEating-disorder psychopathologyClinical significancePhysical activityCompensatory behaviorsBinge-eating episodesAbsence of bingeEating Disorder PsychopathologyLower depression levelsLow-frequency thresholdsWeb-based surveyDepression levelsSmall sample sizeHigher depressionOverall frequencyLaxativesTreatment researchMost domainsExerciseBingePsychopathologyDisordersDepressionParticipantsSimilar levelsFurther supportExamining motivational interviewing plus nutrition psychoeducation for weight loss in primary care
Barnes RD, Ivezaj V, Martino S, Pittman BP, Paris M, Grilo CM. Examining motivational interviewing plus nutrition psychoeducation for weight loss in primary care. Journal Of Psychosomatic Research 2017, 104: 101-107. PMID: 29275778, PMCID: PMC5774024, DOI: 10.1016/j.jpsychores.2017.11.013.Peer-Reviewed Original ResearchConceptsBinge-eating disorderNutrition psychoeducationMotivational interviewingUsual careAttention control conditionWeight lossPrimary careBasic nutrition informationOverweight/obesityModerate weight lossPsychological improvementPsychoeducationMore weight lossMixed model analysisMixed-model analysisPrognostic significanceTreatment completionScalable combinationCurrent studyPercentage weight lossParticipantsBed statusNutrition informationCareGreater improvementReplication of a Modified Factor Structure for the Eating Disorder Examination‐Questionnaire: Extension to Clinical Eating Disorder and Non‐clinical Samples in Portugal
Machado PPP, Grilo CM, Crosby RD. Replication of a Modified Factor Structure for the Eating Disorder Examination‐Questionnaire: Extension to Clinical Eating Disorder and Non‐clinical Samples in Portugal. European Eating Disorders Review 2017, 26: 75-80. PMID: 29152813, DOI: 10.1002/erv.2569.Peer-Reviewed Original ResearchConceptsEating Disorder Examination QuestionnaireTreatment-seeking sampleNon-clinical sampleConfirmatory factor analysis findingsDisorder Examination QuestionnaireOriginal scale structureConfirmatory factor analysisFactor analysis findingsExamination QuestionnairePsychometric investigationClinical samplesBrief versionPortuguese sampleDisorder groupFactor structureObese sampleDisorder diagnosisFactor analysisFactor loadingsReliable findingsFemale studentsPoor fitFindingsBest fitAnalysis findingsForm and Formulation: Examining the Distinctiveness of Body Image Constructs in Treatment-Seeking Patients With Binge-Eating Disorder
Lydecker JA, White MA, Grilo CM. Form and Formulation: Examining the Distinctiveness of Body Image Constructs in Treatment-Seeking Patients With Binge-Eating Disorder. Journal Of Consulting And Clinical Psychology 2017, 85: 1095-1103. PMID: 29083224, PMCID: PMC5679782, DOI: 10.1037/ccp0000258.Peer-Reviewed Original ResearchConceptsBody image variablesBody image disturbanceBody image constructsBinge-eating disorderImage constructImage variablesWeight/shape overvaluationBinge-eating frequencyInvestigator-based interviewBiopsychosocial featuresEating-disorder psychopathologyTreatment-seeking patientsShape preoccupationShape dissatisfactionShape overvaluationShape concernsCore aspectsCurrent studyTreatment formulationConstructsImportant distinctionDifferent aspectsOvervaluationPreoccupationDisordersBack to Basics? No Weight Loss from Motivational Interviewing Compared to Nutrition Psychoeducation at One‐Year Follow‐Up
Barnes RD, Ivezaj V, Martino S, Pittman BP, Grilo CM. Back to Basics? No Weight Loss from Motivational Interviewing Compared to Nutrition Psychoeducation at One‐Year Follow‐Up. Obesity 2017, 25: 2074-2078. PMID: 29086484, PMCID: PMC5705439, DOI: 10.1002/oby.21972.Peer-Reviewed Original ResearchConceptsWeight loss interventionPrimary careBinge-eating disorderWeight lossNutrition psychoeducationLoss interventionSecondary end point analysisWeight loss 12 monthsAttention-controlled comparisonMotivational interviewingMIC patientsEnd-point analysisTreatment conclusionOne-yearBed statusSmall effect sizesCareMonthsPatientsInterventionEffect sizeTreatmentPsychoeducationLong-term impactMixed modelsDoes your child's weight influence how you judge yourself as a parent? A cross-sectional study to define and examine parental overvaluation of weight/shape
Lydecker JA, Grilo CM. Does your child's weight influence how you judge yourself as a parent? A cross-sectional study to define and examine parental overvaluation of weight/shape. Preventive Medicine 2017, 105: 265-270. PMID: 28987340, PMCID: PMC5659758, DOI: 10.1016/j.ypmed.2017.10.009.Peer-Reviewed Original ResearchConceptsWeight/shapeParental overvaluationPersonal weightEating-disorder psychopathologyBinge-eating disorderEating PsychopathologyParent psychopathologyPediatric obesityDearth of researchChild weightCross-sectional designParental attitudesPsychopathologyImportant psychopathologyDisorder treatmentCross-sectional studyParentsCurrent studyIntegral stakeholdersWeight influenceOvervaluationClinical attentionChild BMIChild healthRelated conceptsPersonality and Life Events in a Personality Disorder Sample
Timoney LR, Walsh Z, Shea MT, Yen S, Ansell EB, Grilo CM, McGlashan TH, Stout RL, Bender DS, Skodol AE, Sanislow CA, Morey LC, Gunderson JG. Personality and Life Events in a Personality Disorder Sample. Personality Disorders Theory Research And Treatment 2017, 8: 376-382. PMID: 27797543, PMCID: PMC5411350, DOI: 10.1037/per0000214.Peer-Reviewed Original ResearchConceptsPositive life eventsNegative life eventsLife eventsNormal personality traitsPersonality disorderPersonality traitsCommunity sampleFFM traitsPD groupLives of individualsPresent researchPersonalityMajor depressive disorderFactor modelClinical samplesIndividualsControl groupDepressive disorderConscientiousnessAvoidantExtraversionDisordersNeuroticismTraitsSchizotypal