2023
Cognitive‐behavioral therapy for binge‐eating disorder for non‐responders to initial acute treatments: Randomized controlled trial
Grilo C, Lydecker J, Gueorguieva R. Cognitive‐behavioral therapy for binge‐eating disorder for non‐responders to initial acute treatments: Randomized controlled trial. International Journal Of Eating Disorders 2023, 56: 1544-1553. PMID: 37144325, PMCID: PMC10524840, DOI: 10.1002/eat.23975.Peer-Reviewed Original ResearchMeSH KeywordsAdultBinge-Eating DisorderBulimiaCognitive Behavioral TherapyFemaleHumansMaleMiddle AgedObesityProspective StudiesTreatment OutcomeConceptsInitial acute treatmentBinge-eating disorderCognitive behavioral therapyAcute treatmentBinge-eating frequencyInitial interventionTherapist-led cognitive behavioural therapyInitial pharmacological treatmentTreat remission ratesEvidence-based treatmentsSingle-site trialAcute efficacyRemission rateAdult patientsInitial treatmentPharmacological treatmentPatientsPosttreatment assessmentBehavioral treatmentSufficient benefitTherapyDisordersInterventionTreatmentPharmacotherapyPredictors and significance of rapid response to behaviorally based treatment of binge eating disorder
Yurkow S, Ivezaj V, Grilo C. Predictors and significance of rapid response to behaviorally based treatment of binge eating disorder. Obesity 2023, 31: 390-398. PMID: 36623872, PMCID: PMC9877118, DOI: 10.1002/oby.23648.Peer-Reviewed Original ResearchMeSH KeywordsBinge-Eating DisorderBulimiaCognitive Behavioral TherapyHumansPrognosisTreatment OutcomeWeight LossConceptsDemographic featuresTreatment attitudesWeight lossFourth treatment weekWeight loss outcomesPsychiatric variablesSuperior clinical outcomesWeight loss treatmentTreatment of bingeClinical severity variablesClinical outcomesPrognostic significanceTreatment weekClinical trialsBaseline predictorsLoss outcomesLoss treatmentPosttreatment outcomesBinge eatingIndependent assessorsBingeSeverity variablesDisordersPatientsTreatment
2022
Examining changes in binge‐eating disorder network centrality and structure in patients treated with cognitive‐behavioral therapy versus interpersonal psychotherapy
Forrest L, Franko D, Thompson‐Brenner H, Grilo C. Examining changes in binge‐eating disorder network centrality and structure in patients treated with cognitive‐behavioral therapy versus interpersonal psychotherapy. International Journal Of Eating Disorders 2022, 56: 944-955. PMID: 36565241, PMCID: PMC10159900, DOI: 10.1002/eat.23883.Peer-Reviewed Original ResearchMeSH KeywordsAdultBinge-Eating DisorderCognitive Behavioral TherapyFemaleHumansInterpersonal PsychotherapyMaleMiddle AgedTreatment OutcomeConceptsBinge-eating disorderCognitive behavioral therapyEvidence-based treatmentsInterpersonal psychotherapyIntervention targetsBinge-eating disorder symptomsBehavioral therapyIndicator of remissionShape concernsRefinement of treatmentClinical utilityFrequent associationClinical implicationsSymptomsSymptom interactionsTherapyInterpersonal therapyWeight concernsDisorder symptomsSymptom relationshipsDisordersPatientsTreatmentSizeable minorityNetwork of symptoms
2017
Correlates of weight-related quality of life among individuals with binge eating disorder before and after cognitive behavioral therapy
Mason TB, Crosby RD, Kolotkin RL, Grilo CM, Mitchell JE, Wonderlich SA, Crow SJ, Peterson CB. Correlates of weight-related quality of life among individuals with binge eating disorder before and after cognitive behavioral therapy. Eating Behaviors 2017, 27: 1-6. PMID: 28843136, PMCID: PMC5700842, DOI: 10.1016/j.eatbeh.2017.08.001.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBinge-Eating DisorderBody WeightCognitive Behavioral TherapyFemaleFollow-Up StudiesHumansMaleMiddle AgedObesityQuality of LifeTreatment OutcomeYoung AdultConceptsCognitive behavioral therapyED psychopathologyBody mass indexWeight-related qualityBehavioral therapyEnd of treatmentSelf-report measuresPhysical functionSubjective bingeDisorder psychopathologyPublic distressPsychosocial variablesLongitudinal associationsPsychosocial factorsPsychopathologyNumber of EDsCopingBingeCurrent studyMass indexAvailable treatmentsDistressPredictor variablesFollowing associationsWeight lossEvaluation of a web-based cognitive behavioral smoking cessation treatment for overweight/obese smokers
White MA, Ivezaj V, Grilo CM. Evaluation of a web-based cognitive behavioral smoking cessation treatment for overweight/obese smokers. Journal Of Health Psychology 2017, 24: 1796-1806. PMID: 28810442, DOI: 10.1177/1359105317701560.Peer-Reviewed Original ResearchConceptsSmoking cessation treatmentCessation treatmentObese smokersCognitive-behavioral treatmentBehavioral treatmentCognitive-behavioral smoking cessation treatmentBehavioral smoking cessation treatmentNicotine replacement therapyOverweight/obesityCessation ratesReplacement therapyRegular smokersStandard treatmentHealth educationLarger studySmokersPerson assessmentPilot studyCommunity volunteersTreatmentLess weightKey outcomesParticipantsObesityTherapyPsychological and Behavioral Treatments for Binge-Eating Disorder.
Grilo CM. Psychological and Behavioral Treatments for Binge-Eating Disorder. The Journal Of Clinical Psychiatry 2017, 78 Suppl 1: 20-24. PMID: 28125175, DOI: 10.4088/jcp.sh16003su1c.04.Peer-Reviewed Original ResearchMeSH KeywordsBinge-Eating DisorderBody ImageCognitive Behavioral TherapyEvidence-Based MedicineHumansPsychotherapyTreatment OutcomeWeight LossConceptsBinge-eating disorderBehavioral treatmentBehavioral weight loss therapyCognitive behavioral therapyBinge Eating DisorderBehavioral treatment optionsInterpersonal psychotherapyIntervention protocolBetter outcomesSignificant predictorsWeight lossModest weight lossWeight loss therapyBody shapeReliable predictorTreatment outcomesLoss therapyTreatment optionsDisordersInterventionModeratorPredictorsPsychotherapyPatientsTherapy
2016
Binge abstinence is associated with reduced energy intake after treatment in patients with binge eating disorder and obesity
Masheb RM, Dorflinger LM, Rolls BJ, Mitchell DC, Grilo CM. Binge abstinence is associated with reduced energy intake after treatment in patients with binge eating disorder and obesity. Obesity 2016, 24: 2491-2496. PMID: 27797154, PMCID: PMC5172456, DOI: 10.1002/oby.21664.Peer-Reviewed Original ResearchMeSH KeywordsAdultBinge-Eating DisorderBody WeightBulimiaCognitive Behavioral TherapyDietDietary SucroseEatingEnergy IntakeFatigueFemaleFruitHumansMaleMiddle AgedObesityTreatment OutcomeConceptsCognitive behavioral therapyPsychological functioningBinge abstinencePsychological outcomesCombination of CBTBehavioral therapyBingeRecall interviewsFunctioningAbstinence ratesDietary recall interviewsReduced energy intakeAbstinenceSignificant reductionWeight statusPsychiatric morbidityGreater improvementAdult patientsDietary counselingFruit intakeSugar intakeEnergy intakeDisordersAbstinentComplete cessationCombining Pharmacological and Psychological Treatments for Binge Eating Disorder: Current Status, Limitations, and Future Directions
Grilo CM, Reas DL, Mitchell JE. Combining Pharmacological and Psychological Treatments for Binge Eating Disorder: Current Status, Limitations, and Future Directions. Current Psychiatry Reports 2016, 18: 55. PMID: 27086316, DOI: 10.1007/s11920-016-0696-z.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Obesity AgentsBinge-Eating DisorderBulimia NervosaCognitive Behavioral TherapyFructoseHumansLactonesObesityOrlistatRandomized Controlled Trials as TopicTopiramateWeight LossConceptsCognitive behavioral therapyBinge Eating DisorderFuture treatment researchPsychological treatmentBehavioral therapyRecurrent bingeEating DisordersCompensatory behaviorsTreatment researchPharmacological treatmentHeightened levelsBehavioral weight loss interventionFuture researchWeight loss interventionLimited researchCurrent clinical practiceBingeCertain medicationsLoss interventionFuture directionsBWLClinical practiceWeight controlDisordersSuperior outcomes
2015
Predicting Meaningful Outcomes to Medication and Self-Help Treatments for Binge-Eating Disorder in Primary Care: The Significance of Early Rapid Response
Grilo CM, White MA, Masheb RM, Gueorguieva R. Predicting Meaningful Outcomes to Medication and Self-Help Treatments for Binge-Eating Disorder in Primary Care: The Significance of Early Rapid Response. Journal Of Consulting And Clinical Psychology 2015, 83: 387-394. PMID: 25622201, PMCID: PMC4380674, DOI: 10.1037/a0038635.Peer-Reviewed Original ResearchConceptsBinge-eating disorderSelf-help cognitive behavioral therapyPrimary care settingObese patientsFourth treatment weekBaseline clinical characteristicsBetter clinical outcomesPrimary care physiciansObese patient groupRandomized clinical trialsStrong prognostic indicatorSelf-help interventionEating-disorder psychopathologyImportant clinical implicationsCognitive behavioral therapyAntiobesity medicationsClinical characteristicsMixed-effects model analysisClinical outcomesPercent weight lossPatient groupPrognostic indicatorTreatment weekClinical trialsResearch clinicians
2014
Treatment of binge eating disorder in racially and ethnically diverse obese patients in primary care: Randomized placebo-controlled clinical trial of self-help and medication
Grilo CM, Masheb RM, White MA, Gueorguieva R, Barnes RD, Walsh BT, McKenzie KC, Genao I, Garcia R. Treatment of binge eating disorder in racially and ethnically diverse obese patients in primary care: Randomized placebo-controlled clinical trial of self-help and medication. Behaviour Research And Therapy 2014, 58: 1-9. PMID: 24857821, PMCID: PMC4074556, DOI: 10.1016/j.brat.2014.04.002.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAnti-Obesity AgentsBinge-Eating DisorderBlack or African AmericanBody WeightCognitive Behavioral TherapyCombined Modality TherapyCyclobutanesDouble-Blind MethodFemaleHispanic or LatinoHumansMaleMiddle AgedObesityPrimary Health CareSelf CareTime FactorsTreatment OutcomeWhite PeopleYoung AdultConceptsSelf-help cognitive behavioral therapyDiverse obese patientsAnti-obesity medicationsObese patientsModerate clinical outcomePercent weight lossTime interaction effectsWeight lossClinical outcomesPrimary careRandomized placebo-controlled clinical trialSecond placebo-controlled trialPlacebo-controlled clinical trialAcute weight lossPlacebo-controlled trialDouble-blind fashionDiscontinuation of medicationPrimary care settingWeight loss maintenanceSpecialist treatment centresTreatment of bingeDiverse patient groupsSelf-help CBTBinge-eating frequencyDemographic factors
2013
Self-help for binge eating disorder in primary care: A randomized controlled trial with ethnically and racially diverse obese patients
Grilo CM, White MA, Gueorguieva R, Barnes RD, Masheb RM. Self-help for binge eating disorder in primary care: A randomized controlled trial with ethnically and racially diverse obese patients. Behaviour Research And Therapy 2013, 51: 855-861. PMID: 24189569, PMCID: PMC3863907, DOI: 10.1016/j.brat.2013.10.002.Peer-Reviewed Original ResearchMeSH KeywordsBinge-Eating DisorderBody Mass IndexCognitive Behavioral TherapyCombined Modality TherapyDepressionFemaleHumansMaleMiddle AgedObesityPrimary Health CareSelf CareTreatment OutcomeConceptsDiverse obese patientsUsual careObese patientsSelf-help CBTPrimary careEating Disorder ExaminationPrimary care interventionsPrimary care settingSelf-help versionFour-month treatmentSelf-help treatmentFront-line interventionCognitive behavioral therapyRemission rateMixed modelsCare interventionsCare settingsPatientsGeneralist settingsBehavioral therapyDisorder ExaminationDisorder psychopathologyWeight lossBingeCare
2011
Cognitive–Behavioral Therapy, Behavioral Weight Loss, and Sequential Treatment for Obese Patients With Binge-Eating Disorder: A Randomized Controlled Trial
Grilo CM, Masheb RM, Wilson GT, Gueorguieva R, White MA. Cognitive–Behavioral Therapy, Behavioral Weight Loss, and Sequential Treatment for Obese Patients With Binge-Eating Disorder: A Randomized Controlled Trial. Journal Of Consulting And Clinical Psychology 2011, 79: 675-685. PMID: 21859185, PMCID: PMC3258572, DOI: 10.1037/a0025049.Peer-Reviewed Original ResearchConceptsPercent BMI lossBehavioral weight lossBinge-eating disorderCognitive behavioral therapyBMI lossObese patientsWeight lossBinge-eating remissionAlternative treatment optionBinge Eating DisorderRemission rateControlled TrialsTreatment optionsMixed model analysisBehavioral therapyPatientsManualized treatmentAssessment pointsBingeRemissionGreater reductionTreatmentTherapySequential treatmentDisordersA randomized controlled trial for obesity and binge eating disorder: Low-energy-density dietary counseling and cognitive-behavioral therapy
Masheb RM, Grilo CM, Rolls BJ. A randomized controlled trial for obesity and binge eating disorder: Low-energy-density dietary counseling and cognitive-behavioral therapy. Behaviour Research And Therapy 2011, 49: 821-829. PMID: 22005587, PMCID: PMC3223390, DOI: 10.1016/j.brat.2011.09.006.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyWeight lossDietary counselingVegetable consumptionPercent of participantsBinge remissionObese patientsRemission outcomesNutrition counselingMetabolic outcomesObese individualsConsecutive participantsFavorable outcomeDietary outcomesTwelve-monthBetter dietary outcomesDensity dietIndividual treatmentTreatment effectsOutcomesTherapyCounselingTreatmentBingeDisorders
2007
Rapid Response Predicts Treatment Outcomes in Binge Eating Disorder: Implications for Stepped Care
Masheb RM, Grilo CM. Rapid Response Predicts Treatment Outcomes in Binge Eating Disorder: Implications for Stepped Care. Journal Of Consulting And Clinical Psychology 2007, 75: 639-644. PMID: 17663617, DOI: 10.1037/0022-006x.75.4.639.Peer-Reviewed Original ResearchConceptsWeight lossCare treatment modelMost patient characteristicsRandomized clinical trialsDifferent prognostic significanceSelf-help treatmentBinge Eating DisorderBinge remissionOverweight patientsPatient characteristicsPrognostic significanceStepped careTreatment weekClinical trialsTreatment outcomesDepressive symptomsDepressive symptomatologyCBTgshEating DisordersBingeTreatment modelGreater reductionTreatment effectsGreater improvementDisordersNaltrexone and Cognitive Behavioral Coping Skills Therapy for the Treatment of Alcohol Drinking and Eating Disorder Features in Alcohol‐Dependent Women: A Randomized Controlled Trial
O'Malley SS, Sinha R, Grilo CM, Capone C, Farren CK, McKee SA, Rounsaville BJ, Wu R. Naltrexone and Cognitive Behavioral Coping Skills Therapy for the Treatment of Alcohol Drinking and Eating Disorder Features in Alcohol‐Dependent Women: A Randomized Controlled Trial. Alcohol Clinical And Experimental Research 2007, 31: 625-634. PMID: 17374042, DOI: 10.1111/j.1530-0277.2007.00347.x.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalAdultAlcohol DrinkingAlcoholismAttitudeBody Mass IndexBulimiaCognitive Behavioral TherapyCombined Modality TherapyDepressionFeeding and Eating DisordersFemaleGamma-GlutamyltransferaseHumansNaltrexoneNarcotic AntagonistsPsychiatric Status Rating ScalesTreatment OutcomeConceptsCognitive Behavioral Coping Skills TherapyAlcohol-dependent womenEfficacy of naltrexoneCoping skills therapyAlcohol dependenceOutpatient research clinicSkills therapyCo-occurring psychiatric conditionsEating Disorder FeaturesDSM-IV criteriaPercentage of participantsPrimary outcomeControlled TrialsAlcohol drinkingMedication conditionResearch clinicNaltrexonePsychiatric conditionsSecondary analysisImportant gender differencesTotal abstinenceHeavy drinkingPathologyWomenDrinking outcomes
2005
A randomized controlled comparison of guided self-help cognitive behavioral therapy and behavioral weight loss for binge eating disorder
Grilo CM, Masheb RM. A randomized controlled comparison of guided self-help cognitive behavioral therapy and behavioral weight loss for binge eating disorder. Behaviour Research And Therapy 2005, 43: 1509-1525. PMID: 16159592, DOI: 10.1016/j.brat.2004.11.010.Peer-Reviewed Original ResearchConceptsSelf-help cognitive behavioral therapyCognitive behavioral therapyWeight lossConsecutive overweight patientsHigher remission ratesBehavioral weight lossTreatment of BEDOverweight patientsRemission rateTreat analysisMinimal therapist guidanceHigher completion ratesTherapist guidanceBehavioral therapyCBTgshControl treatment conditionsSelf-help approachTreatment treatmentNon-specific influencesRelative efficacyTreatmentCompletion ratesTherapyBingeDisordersCognitive Behavioral Therapy Guided Self-Help and Orlistat for the Treatment of Binge Eating Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial
Grilo CM, Masheb RM, Salant SL. Cognitive Behavioral Therapy Guided Self-Help and Orlistat for the Treatment of Binge Eating Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial. Biological Psychiatry 2005, 57: 1193-1201. PMID: 15866560, DOI: 10.1016/j.biopsych.2005.03.001.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyWeight lossSelf-help cognitive behavioral therapyAddition of placeboFacilitate weight lossTreat remission ratesPercent of patientsDouble-blind fashionPlacebo-controlled studyAddition of orlistatGreater weight lossGuided Self-HelpObese BED patientsBinge Eating DisorderRemission rateTreatment discontinuationClinical improvementObesity medicationsBED patientsCBTgshOrlistatPlaceboBehavioral therapyDisorder psychopathologyComparable improvementEfficacy of cognitive behavioral therapy and fluoxetine for the treatment of binge eating disorder: A randomized double-blind placebo-controlled comparison
Grilo CM, Masheb RM, Wilson GT. Efficacy of cognitive behavioral therapy and fluoxetine for the treatment of binge eating disorder: A randomized double-blind placebo-controlled comparison. Biological Psychiatry 2005, 57: 301-309. PMID: 15691532, DOI: 10.1016/j.biopsych.2004.11.002.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntidepressive Agents, Second-GenerationBulimiaCognitive Behavioral TherapyCross-Over StudiesDouble-Blind MethodFemaleFluoxetineHumansMaleMiddle AgedSecondary PreventionTreatment OutcomeConceptsCognitive behavioral therapyBehavioral therapyEfficacy of CBTTreatment of bingeTreat remission ratesCBT conditionCognitive featuresPsychological featuresPsychological distressDimensional measuresBingeRemission rateDouble-blind placebo-controlled comparisonDouble-blind fashionPlacebo-controlled comparisonPlacebo-controlled studyConsistent findingCompletersIndividual treatmentCertain medicationsPharmacological therapyITT analysisFluoxetineDisordersPlacebo
1999
Bulimia Nervosa and Alcohol Dependence A Case Report of a Patient Enrolled in a Randomized Controlled Clinical Trial
Daniels E, Masheb R, Berman R, Mickley D, Grilo C. Bulimia Nervosa and Alcohol Dependence A Case Report of a Patient Enrolled in a Randomized Controlled Clinical Trial. Journal Of Substance Use And Addiction Treatment 1999, 17: 163-166. PMID: 10435265, DOI: 10.1016/s0740-5472(98)00061-0.Peer-Reviewed Original ResearchConceptsBulimia nervosaCase reportClinical trialsAlcohol dependenceCo-occurring alcohol dependenceDouble-blind random assignmentTreatment of patientsA Case ReportAlcohol use disorderAugmentation trialComorbid conditionsPatient's symptomsEfficacy trialsCaucasian femaleUse disordersPlacebo effectPlacebo conditionPaucity of informationPatientsNervosaExclusionary criteriaTrialsIntervention proceduresSymptomsRandom assignment
1998
Pretreatment patient factors predicting attrition from a multicenter randomized controlled treatment study for panic disorder
Grilo C, Money R, Barlow D, Goddard A, Gorman J, Hofmann S, Papp L, Shear M, Woods S. Pretreatment patient factors predicting attrition from a multicenter randomized controlled treatment study for panic disorder. Comprehensive Psychiatry 1998, 39: 323-332. PMID: 9829138, DOI: 10.1016/s0010-440x(98)90043-8.Peer-Reviewed Original ResearchConceptsPanic disorderFinal multivariate regression analysisMultivariate regression analysisLower household incomeNegative treatment attitudesPatient factorsPsychiatric comorbidityClinical trialsStudy groupPretreatment factorsClinical practicePrior treatmentTreatment studiesTreatment attitudesPredictor analysisLower educationAgoraphobic avoidanceLife stressorsTrend levelDisordersPatientsRegression analysisTreatmentGreater ageSocial support