2023
Naltrexone/bupropion for binge‐eating disorder: A randomized, double‐blind, placebo‐controlled trial
Grilo C, Lydecker J, Jastreboff A, Pittman B, McKee S. Naltrexone/bupropion for binge‐eating disorder: A randomized, double‐blind, placebo‐controlled trial. Obesity 2023, 31: 2762-2773. PMID: 37751990, PMCID: PMC10600891, DOI: 10.1002/oby.23898.Peer-Reviewed Original ResearchConceptsNaltrexone/bupropionBinge-eating disorderObesity statusLogistic regressionWeight lossPlacebo-controlled trialWeight loss outcomesPrevalent psychiatric disordersEvidence-based treatmentsPost-treatment assessmentBinge-eating frequencyGreater percentage weight lossMedication outcomesRemission ratePharmacological optionsPlaceboBupropionPsychiatric disordersPercentage weight lossMixed modelsDisordersObesityPatientsSignificant reductionWeight reductionPsychiatric comorbidity as a prospective predictor of long-term weight and psychosocial outcomes after bariatric surgery
Ivezaj V, Dilip A, Grilo C. Psychiatric comorbidity as a prospective predictor of long-term weight and psychosocial outcomes after bariatric surgery. General Hospital Psychiatry 2023, 83: 51-58. PMID: 37099869, DOI: 10.1016/j.genhosppsych.2023.03.005.Peer-Reviewed Original ResearchConceptsEating Disorder Examination-Bariatric Surgery VersionLong-term weight outcomesPost-bariatric surgeryPsychiatric comorbidityEating-disorder psychopathologyBariatric surgeryWeight outcomesMonths post-bariatric surgeryMini International Neuropsychiatric InterviewWeight loss outcomesCurrent psychiatric disorderCurrent psychiatric comorbidityInternational Neuropsychiatric InterviewPsychosocial functioning outcomesLong-term weightBeck Depression InventoryPoor psychosocial functioningPrognostic significanceProspective studyBariatric populationNeuropsychiatric InterviewClinical significanceComorbiditiesLoss outcomesPsychiatric disorders
2016
Binge-eating disorder and major depressive disorder co-morbidity: Sequence and clinical significance
Grilo C, Becker D. Binge-eating disorder and major depressive disorder co-morbidity: Sequence and clinical significance. European Psychiatry 2016, 33: s163. DOI: 10.1016/j.eurpsy.2016.01.322.Peer-Reviewed Original ResearchOnset of MDDOnset of BEDMajor depressive disorderEating-disorder psychopathologyPsychiatric comorbidityDepressive disorderDSM-IV-TR research criteriaEarly onsetCo-occurring major depressive disorderLifetime psychiatric disordersED psychopathologyCo-occurring disordersBinge-eating disorderMeaningful adverse effectsBinge-eating frequencyElevated ratesOrder of onsetTreatment-seeking patientsConsecutive seriesClinical significanceBED patientsPsychiatric disordersMDD groupDiagnostic comorbidityComorbidities
2015
Psychosocial and metabolic function by smoking status in individuals with binge eating disorder and obesity
Udo T, White MA, Barnes RD, Ivezaj V, Morgan P, Masheb RM, Grilo CM. Psychosocial and metabolic function by smoking status in individuals with binge eating disorder and obesity. Addictive Behaviors 2015, 53: 46-52. PMID: 26451703, PMCID: PMC4679522, DOI: 10.1016/j.addbeh.2015.09.018.Peer-Reviewed Original ResearchConceptsTreatment-seeking adultsTreatment-seeking patientsSubstance use disordersDisorder psychopathologyCurrent smokersFormer smokersPsychosocial functioningComorbid psychiatric disordersSmoking statusLifetime psychiatric comorbidityUse disordersLifetime diagnostic criteriaPotential long-term implicationsFunctioningBingePsychiatric comorbidityMeeting criteriaPsychiatric disordersMetabolic functionsMetabolic functioningMetabolic riskMetabolic syndromeMetabolic abnormalitiesSmoking cessationSmokers
2011
Stressful life events predict eating disorder relapse following remission: Six‐year prospective outcomes
Grilo CM, Pagano ME, Stout RL, Markowitz JC, Ansell EB, Pinto A, Zanarini MC, Yen S, Skodol AE. Stressful life events predict eating disorder relapse following remission: Six‐year prospective outcomes. International Journal Of Eating Disorders 2011, 45: 185-192. PMID: 21448971, PMCID: PMC3275672, DOI: 10.1002/eat.20909.Peer-Reviewed Original ResearchConceptsStressful life eventsPersonality disorder statusBulimia nervosaLife eventsNegative stressful life eventsSignificant warning signsED relapseSignificant predictorsComorbid psychiatric disordersStructured Clinical InterviewSocial stressorsAssessment interviewsSocial stressDiagnostic InterviewClinical InterviewDisorder relapsePersonality disorderED durationLongitudinal intervalDSM-IVStructured interviewsEDNOSPsychiatric comorbidityPsychiatric disordersElevated work
2010
Ethnicity in trauma and psychiatric disorders: findings from the collaborative longitudinal study of personality disorders
Benítez C, Yen S, Shea MT, Edelen MO, Markowitz JC, McGlashan TH, Ansell EB, Grilo CM, Skodol AE, Gunderson JG, Morey LC. Ethnicity in trauma and psychiatric disorders: findings from the collaborative longitudinal study of personality disorders. Journal Of Clinical Psychology 2010, 66: 583-598. PMID: 20455250, PMCID: PMC3719974, DOI: 10.1002/jclp.20686.Peer-Reviewed Original ResearchConceptsNon-Hispanic whitesPsychiatric disordersAfrican AmericansHigh ratePersonality disorderMajor depressive disorderCollaborative Longitudinal Personality Disorders StudyCollaborative longitudinal studyBorderline personality disorderLifetime traumatic eventsAdverse childhood experiencesAdverse eventsDepressive disorderPersonality Disorders StudyInjury/Mental disordersStudy aimSubstance useDisordersDisorders StudySerious injuriesEthnic differencesLongitudinal studySimilar traumaPosttraumatic stress
1996
A comparison of adolescent inpatients with and without substance abuse using the Millon Adolescent Clinical Inventory
Grilo C, Fehon D, Walker M, Martino S. A comparison of adolescent inpatients with and without substance abuse using the Millon Adolescent Clinical Inventory. Journal Of Youth And Adolescence 1996, 25: 379-388. DOI: 10.1007/bf01537391.Peer-Reviewed Original ResearchSUD subjectsAdolescent inpatientsSubstance use disordersMajor psychiatric disordersMillon Adolescent Clinical InventoryOverall sample populationClinical syndromeClinical InventoryPsychiatric hospitalizationFunctional severityPsychiatric disordersUse disordersSubstance abuseInpatientsLow levelsHigh levelsDisorders
1995
Psychiatric Comorbidity in Adolescent Inpatients with Substance Use Disorders
GRILO C, BECKER D, WALKER M, LEVY K, EDELL W, McGLASHAN T. Psychiatric Comorbidity in Adolescent Inpatients with Substance Use Disorders. Journal Of The American Academy Of Child & Adolescent Psychiatry 1995, 34: 1085-1091. PMID: 7665447, DOI: 10.1097/00004583-199508000-00019.Peer-Reviewed Original ResearchConceptsSubstance use disordersAdolescent inpatientsPersonality disorderUse disordersSUD groupNon-SUD patientsAxis I DisordersAxis II personality disordersCluster B personality disordersPsychiatric comparison groupBorderline personality disorderB personality disordersStructured diagnostic interviewDisruptive behavior disordersSignificant comorbiditiesOppositional defiant disorderPsychiatric comorbidityConsecutive seriesSUD patientsI disordersPsychiatric disordersPatientsInpatientsDiagnostic InterviewBehavior disorder