2008
A Serpin that Regulates Immune Melanization in the Respiratory System of Drosophila
Tang H, Kambris Z, Lemaitre B, Hashimoto C. A Serpin that Regulates Immune Melanization in the Respiratory System of Drosophila. Developmental Cell 2008, 15: 617-626. PMID: 18854145, PMCID: PMC2671232, DOI: 10.1016/j.devcel.2008.08.017.Peer-Reviewed Original ResearchConceptsAntifungal peptide drosomycinInternal tissuesToll pathwayChemical defensesProtease cascadeMelanin biosynthesisMelanization reactionKey enzymeSerpin familyDrosophilaMelanizationPresence of microorganismsEpithelial tissuesMicrobial infectionsPhenol oxidaseHost defenseSystemic expressionEpithelial defenseProtease inhibitorsDefensePhysical barrierPathogensDrosomycinBiosynthesisTissue
2003
Spatial Regulation of Developmental Signaling by a Serpin
Hashimoto C, Kim DR, Weiss LA, Miller JW, Morisato D. Spatial Regulation of Developmental Signaling by a Serpin. Developmental Cell 2003, 5: 945-950. PMID: 14667416, DOI: 10.1016/s1534-5807(03)00338-1.Peer-Reviewed Original ResearchConceptsExtracellular serine protease cascadeDiverse biological processesSerine protease cascadeDevelopmental signalingDrosophila embryosDorsoventral polarityBlood-clotting cascadeSpatial regulationSerine protease inhibitorProtease cascadeBiological processesGeneral mechanismEssential roleProtease activitySpatial controlEmbryosCascadeProtease inhibitorsVentral sideMammalianSerpinsSignalingRegulationPathwayRole