2012
Does baseline cerebral blood flow affect task-related blood oxygenation level dependent response in schizophrenia?
Liu J, Qiu M, Constable RT, Wexler BE. Does baseline cerebral blood flow affect task-related blood oxygenation level dependent response in schizophrenia? Schizophrenia Research 2012, 140: 143-148. PMID: 22789669, PMCID: PMC3423495, DOI: 10.1016/j.schres.2012.06.028.Peer-Reviewed Original ResearchConceptsCerebral blood flowBlood oxygenation level-dependent (BOLD) responseInter-group differencesHealthy controlsLevel-dependent responsesBOLD responseFrontal cortexGroup differencesBlood flowBaseline cerebral blood flowTask-related BOLD responseBilateral frontal poleRight basal gangliaRight inferior frontal cortexBOLD signal increasesBilateral prefrontal areasMiddle frontal cortexInferior frontal cortexRight fusiform gyrusBilateral thalamusBasal gangliaBOLD studyVascular pathologyPatientsVisual processing areas
2005
Neural activity associated with stress-induced cocaine craving: a functional magnetic resonance imaging study
Sinha R, Lacadie C, Skudlarski P, Fulbright RK, Rounsaville BJ, Kosten TR, Wexler BE. Neural activity associated with stress-induced cocaine craving: a functional magnetic resonance imaging study. Psychopharmacology 2005, 183: 171-180. PMID: 16163517, DOI: 10.1007/s00213-005-0147-8.Peer-Reviewed Original ResearchConceptsStress-induced cocaineCocaine-dependent individualsFunctional magnetic resonance imaging sessionNeural activityFunctional magnetic resonance imaging studyMagnetic resonance imaging sessionCocaine cravingRegulation of emotionHippocampal/parahippocampal regionLevel-dependent signal changesRight fusiform gyrusStress-related vulnerabilityPara-limbic regionsAnterior cingulate regionsRight postcentral gyrusDependent signal changesMagnetic resonance imaging studyResonance imaging studyStress processingFusiform gyrusNeutral situationsSpecific frontalBOLD activationPersonal stressCingulate regionsCue-Induced Brain Activity Changes and Relapse in Cocaine-Dependent Patients
Kosten TR, Scanley BE, Tucker KA, Oliveto A, Prince C, Sinha R, Potenza MN, Skudlarski P, Wexler BE. Cue-Induced Brain Activity Changes and Relapse in Cocaine-Dependent Patients. Neuropsychopharmacology 2005, 31: 644-650. PMID: 16123763, DOI: 10.1038/sj.npp.1300851.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingPosterior cingulate cortexCocaine-related cuesCocaine-dependent patientsBrain activationTreatment effectiveness scoreSensory association corticesBrain activity changesPCC activationCocaine cuesSuperior temporalBOLD activationCingulate cortexSubjective reportsTreatment developmentAssociation cortexCuesProcessing areasCocaine abusePhysiological activationCortexNonrelapsersBest predictorCocaine-free urinesDrug use
2004
Neural Circuits Underlying Emotional Distress in Humans
SINHA R, LACADIE C, SKUDLARSKI P, WEXLER BE. Neural Circuits Underlying Emotional Distress in Humans. Annals Of The New York Academy Of Sciences 2004, 1032: 254-257. PMID: 15677422, DOI: 10.1196/annals.1314.032.Peer-Reviewed Original ResearchConceptsEmotional distressHealthy volunteersFunctional magnetic resonance imaging (fMRI) techniquesStressful life eventsEmotional stressPosterior cingulate regionsPrefrontal cortical circuitsSubstance use disordersStress processingBrain activationBrain correlatesImagery trialsMedial prefrontalAnterior cingulateLife eventsCingulate regionsMagnetic resonance imaging techniquesParahippocampal gyrusCortical circuitsUse disordersHealthy individualsDistressNeural circuitsSignificant activationClinical samples