2023
Aberrant hippocampus and amygdala morphology associated with cognitive deficits in schizophrenia
Peterson B, Kaur T, Sawardekar S, Colibazzi T, Hao X, Wexler B, Bansal R. Aberrant hippocampus and amygdala morphology associated with cognitive deficits in schizophrenia. Frontiers In Cellular Neuroscience 2023, 17: 1126577. PMID: 36909281, PMCID: PMC9996667, DOI: 10.3389/fncel.2023.1126577.Peer-Reviewed Original ResearchClinical symptomsHealthy controlsAnatomical abnormalitiesMemory deficitsPathogenesis of schizophreniaSeverity of symptomsEffects of schizophreniaHippocampal bodyAmygdala morphologyLimbic regionsPatientsHippocampusInward deformationCognitive deficitsBrain structuresHC participantsSchizophreniaAmygdalaSymptomsMemory performanceContinuum of severityAnatomical MRIPrimary disturbanceMemory scoresAbnormalities
2016
Executive Dysfunction Predicts Treatment Response to Neuroplasticity-Based Computerized Cognitive Remediation (nCCR-GD) in Elderly Patients with Major Depression
Morimoto SS, Gunning FM, Wexler BE, Hu W, Ilieva I, Liu J, Nitis J, Alexopoulos GS. Executive Dysfunction Predicts Treatment Response to Neuroplasticity-Based Computerized Cognitive Remediation (nCCR-GD) in Elderly Patients with Major Depression. American Journal Of Geriatric Psychiatry 2016, 24: 816-820. PMID: 27591163, PMCID: PMC5873289, DOI: 10.1016/j.jagp.2016.06.010.Peer-Reviewed Original ResearchConceptsExecutive dysfunctionCognitive remediation interventionsComputerized cognitive remediationPoor treatment responseFavorable treatment responseTreatment responseCognitive remediationRemediation interventionsMajor depressionNeuropsychological performanceElderly patientsOlder adultsLate-life depressionMontgomery-Asberg Depression Rating Scale scoreTreatment-resistant major depressionDepression Rating Scale scoresRating Scale scoresDepressionAntidepressant treatmentTreatment trialsScale scorePatientsBaselineGreater reductionDysfunction
2014
Increasing stimulus duration can normalize late-positive event related potentials in people with schizophrenia: Possible implications for understanding cognitive deficits
Wexler BE, Ikezawa S, Corbera S. Increasing stimulus duration can normalize late-positive event related potentials in people with schizophrenia: Possible implications for understanding cognitive deficits. Schizophrenia Research 2014, 158: 163-169. PMID: 25096541, PMCID: PMC4240766, DOI: 10.1016/j.schres.2014.07.012.Peer-Reviewed Original ResearchConceptsHealthy controlsCognitive deficitsMs stimuliStructured Clinical InterviewDSM-IV criteriaModulation of responsesStimulus durationPictures of handsEvent Related PotentialsAdult outpatientsPain stimuliHealthy peoplePatientsClinical InterviewSchizoaffective disorderSchizophreniaMs stimulusSensory inputStimulus onsetSame durationDurationStimuliDeficitsResponseNeutral stimuliNeural activation abnormalities during self-referential processing in schizophrenia: An fMRI study
Liu J, Corbera S, Wexler BE. Neural activation abnormalities during self-referential processing in schizophrenia: An fMRI study. Psychiatry Research 2014, 222: 165-171. PMID: 24795158, DOI: 10.1016/j.pscychresns.2014.04.003.Peer-Reviewed Original ResearchConceptsActivation abnormalitiesHealthy controlsCortical midline structuresMidline structuresBlood oxygenation level-dependent (BOLD) signalLevel-dependent signalFunctional magnetic resonanceGeneral neuropathologySchizophrenia altersTemporal gyrusPatientsAbnormalitiesSchizophreniaActivation paradigmGreater signal increaseGroup differencesFMRI studyPosterior regionSelf-referential processingMothersMagnetic resonanceDependent signalsNeuropathologyControlGyrus
2013
Anatomical Abnormalities in Gray and White Matter of the Cortical Surface in Persons with Schizophrenia
Colibazzi T, Wexler BE, Bansal R, Hao X, Liu J, Sanchez-Peña J, Corcoran C, Lieberman JA, Peterson BS. Anatomical Abnormalities in Gray and White Matter of the Cortical Surface in Persons with Schizophrenia. PLOS ONE 2013, 8: e55783. PMID: 23418459, PMCID: PMC3572102, DOI: 10.1371/journal.pone.0055783.Peer-Reviewed Original ResearchConceptsCortical thicknessWhite matterCortical surface areaGray matterAnatomical abnormalitiesGM volumeWM abnormalitiesContribution of abnormalitiesRegional GM volumeHealthy controlsHigh burdenCingulate gyrusTotal cortical surface areaThinner cortexSuperior frontalAbnormalitiesLocation of abnormalitiesPerisylvian cortexSchizophreniaWM surfaceBrainCortical surfaceBrain anatomyPatientsSerial position task
2012
Empathy in electrodermal responsive and nonresponsive patients with schizophrenia
Ikezawa S, Corbera S, Liu J, Wexler BE. Empathy in electrodermal responsive and nonresponsive patients with schizophrenia. Schizophrenia Research 2012, 142: 71-76. PMID: 23058162, PMCID: PMC3502678, DOI: 10.1016/j.schres.2012.09.011.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalysis of VarianceAntipsychotic AgentsChlorpromazineElectroencephalographyEmpathyEvoked PotentialsFemaleGalvanic Skin ResponseHumansMaleMiddle AgedNeuropsychological TestsPersonality TestsPsychiatric Status Rating ScalesPsychotic DisordersRecognition, PsychologySchizophreniaSchizophrenic PsychologySocial BehaviorConceptsSkin conductance responsesEvent Related PotentialsSocial cognitionEmotion-evoking stimuliHealthy controlsPictures of peopleAssessment of symptomsERP responsesPersonal distressConductance responsesRelated potentialsNonresponsive patientsSchizophrenia patientsSCR frequencyCognitionPatientsSocial functionSocial integrationPotential markerSchizophreniaDistressPainPrognosisSubgroupsSymptomsDoes baseline cerebral blood flow affect task-related blood oxygenation level dependent response in schizophrenia?
Liu J, Qiu M, Constable RT, Wexler BE. Does baseline cerebral blood flow affect task-related blood oxygenation level dependent response in schizophrenia? Schizophrenia Research 2012, 140: 143-148. PMID: 22789669, PMCID: PMC3423495, DOI: 10.1016/j.schres.2012.06.028.Peer-Reviewed Original ResearchConceptsCerebral blood flowBlood oxygenation level-dependent (BOLD) responseInter-group differencesHealthy controlsLevel-dependent responsesBOLD responseFrontal cortexGroup differencesBlood flowBaseline cerebral blood flowTask-related BOLD responseBilateral frontal poleRight basal gangliaRight inferior frontal cortexBOLD signal increasesBilateral prefrontal areasMiddle frontal cortexInferior frontal cortexRight fusiform gyrusBilateral thalamusBasal gangliaBOLD studyVascular pathologyPatientsVisual processing areas
2008
Neurocognitive Enhancement Therapy and Competitive Employment in Schizophrenia: Effects on Clients with Poor Community Functioning
BELL M, ZITO W, GREIG T, WEXLER B. Neurocognitive Enhancement Therapy and Competitive Employment in Schizophrenia: Effects on Clients with Poor Community Functioning. American Journal Of Psychiatric Rehabilitation 2008, 11: 109-122. DOI: 10.1080/15487760801963397.Peer-Reviewed Original ResearchNeurocognitive enhancement therapyEnhancement therapyVocational outcomesDiagnosis of schizophreniaCompetitive employmentCompetitive employment ratesTreat sampleHeinrichs QualitySchizoaffective disorderFunctioning patientsTotal hoursTherapy outcomeMore total hoursCommunity functioningLogistic regressionActive interventionLife ScaleOutcomesPatientsTherapyHigh rateCognitive remediationExecutive functionPoor communitiesSchizophrenia
2007
Severe and Persistent Mental Illness
Wexler B, Davidson L, Styron T, Strauss J. Severe and Persistent Mental Illness. 2007, 1-20. DOI: 10.1002/9780470994580.ch1.Chapters
2005
Neurocognitive Function in Schizophrenia at a 10-Year Follow-Up: A Preliminary Investigation
Kurtz MM, Seltzer JC, Ferrand JL, Wexler BE. Neurocognitive Function in Schizophrenia at a 10-Year Follow-Up: A Preliminary Investigation. CNS Spectrums 2005, 10: 277-280. PMID: 15788955, DOI: 10.1017/s1092852900022598.Peer-Reviewed Original ResearchConceptsNeurocognitive deficitsIntelligence quotientMiddle-age patientsSubgroup of patientsYears of treatmentSpecific neurocognitive skillsWechsler Adult Intelligence ScaleSustained auditory attentionMeasures of attentionNon-verbal memoryException of performanceFull-scale intelligence quotientNeurocognitive test performanceNeuropsychological test batteryAdult Intelligence ScalePatient ageIllness onsetDisease onsetMotor functionAuditory attentionNeurodevelopmental modelPatientsNeurocognitive skillsNeurocognitive functionMotor sequencing
2004
Test–retest stability of neuropsychological testing and individual differences in variability in schizophrenia outpatients
Greig T, Nicholls SS, Wexler BE, Bell MD. Test–retest stability of neuropsychological testing and individual differences in variability in schizophrenia outpatients. Psychiatry Research 2004, 129: 241-247. PMID: 15661317, DOI: 10.1016/j.psychres.2004.09.006.Peer-Reviewed Original ResearchConceptsNeurocognitive functionImpact of treatmentTest-retest variabilityClinical trialsNeuropsychological testingStable outpatientsSchizoaffective disorderMeasures of psychopathologyTest-retest changesMost subjectsSchizophrenia outpatientsBaseline measuresNeuropsychological testsSchizophrenia researchTest-retest stabilityOutpatientsReliable instrumentSignificant changesTreatmentSubject variancePractice effectsSubjectsPatientsNeuropathologyNeuropsychological deficits are associated with smoking cessation treatment failure in patients with schizophrenia
Dolan SL, Sacco KA, Termine A, Seyal AA, Dudas MM, Vessicchio JC, Wexler BE, George TP. Neuropsychological deficits are associated with smoking cessation treatment failure in patients with schizophrenia. Schizophrenia Research 2004, 70: 263-275. PMID: 15329302, DOI: 10.1016/j.schres.2004.01.006.Peer-Reviewed Original ResearchConceptsNon-psychiatric control smokersTreatment failureStroop Color-Word TestContinuous Performance TestNeuropsychological deficitsControl smokersWisconsin Card Sorting TestPlacebo-controlled trialAtypical antipsychotic treatmentCessation treatmentAntipsychotic treatmentCessation interventionsCigarette smokingDepressive symptomsPharmacological agentsColor-Word TestSmokingNeuropsychological assessmentNeuropsychological performanceCard Sorting TestVisuospatial Working Memory TaskGreater deficitsPreliminary dataSmokersPatients
2003
Amygdala hyperreactivity in borderline personality disorder: implications for emotional dysregulation
Donegan NH, Sanislow CA, Blumberg HP, Fulbright RK, Lacadie C, Skudlarski P, Gore JC, Olson IR, McGlashan TH, Wexler BE. Amygdala hyperreactivity in borderline personality disorder: implications for emotional dysregulation. Biological Psychiatry 2003, 54: 1284-1293. PMID: 14643096, DOI: 10.1016/s0006-3223(03)00636-x.Peer-Reviewed Original ResearchConceptsNormal control subjectsBorderline personality disorderControl subjectsBorderline patientsAmygdala hyperreactivityBPD patientsPersonality disorderEmotional dysregulationDisorders of moodFunctional magnetic resonance imagingMagnetic resonance imagingClinical research teamPatientsResonance imagingPsychiatry departmentDSM-IVAmygdala reactivityAmygdala activationDisordersNeural responsesHyperreactivityDysregulationActivation levelsSubjectsRobust differences
2002
Atypical Depression: Enhanced Right Hemispheric Dominance for Perceiving Emotional Chimeric Faces
Bruder GE, Stewart JW, McGrath PJ, Julie G, Wexler BE, Quitkin FM. Atypical Depression: Enhanced Right Hemispheric Dominance for Perceiving Emotional Chimeric Faces. Journal Of Psychopathology And Clinical Science 2002, 111: 446-454. PMID: 12150420, DOI: 10.1037/0021-843x.111.3.446.Peer-Reviewed Original ResearchConceptsMajor depressive disorderAtypical depressionTypical depressionRight hemispheric dominanceNeurophysiologic studiesDepressive disorderHealthy controlsVegetative symptomsPatientsDistinct subtypesDiagnostic distinctionHemisphere biasHemispheric dominanceDepressionDysthymiaRight hemisphere biasFurther evidenceFace testHemispatial biasPhysical anhedoniaSymptomsSubtypesControl
2001
Functional Magnetic Resonance Imaging of Cocaine Craving
Wexler BE, Gottschalk CH, Fulbright RK, Prohovnik I, Lacadie CM, Rounsaville BJ, Gore JC. Functional Magnetic Resonance Imaging of Cocaine Craving. American Journal Of Psychiatry 2001, 158: 86-95. PMID: 11136638, DOI: 10.1176/appi.ajp.158.1.86.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingHealthy subjectsCocaine-dependent subjectsMagnetic resonance imagingResonance imagingCocaine addictsReported onsetBrain activationBrain activityRegional brain activationFrontal lobe activationAnterior cingulate activationNeurobiology of addictionCocaine cravingAnterior cingulatePatientsFrontal lobePhysiologic linkSensory areasComparison of groupsDrug cravingDysphoric statesLess activationGeneral abnormalityCingulate activation
1995
Behavioral laterality in individuals with Gilles de la Tourette's syndrome and basal ganglia alterations: A preliminary report
Yazgan M, Peterson B, Wexler B, Leckman J. Behavioral laterality in individuals with Gilles de la Tourette's syndrome and basal ganglia alterations: A preliminary report. Biological Psychiatry 1995, 38: 386-390. PMID: 8547458, DOI: 10.1016/0006-3223(94)00302-j.Peer-Reviewed Original ResearchConceptsGTS patientsTourette syndromeIntact basal ganglia functionGilles de la Tourette's syndromeGTS subjectsAdult GTS patientsBasal ganglia alterationsBasal ganglia functionLa Tourette's syndromePrevious MRI studiesNeuropsychological measuresFunctional asymmetryGanglia functionTic symptomsNormal controlsMRI studiesSyndromePreliminary reportPatientsNeuropsychological tasksFunctional significanceSubjectsBehavioral lateralitySymptomsAbnormalities
1994
Neuroleptic exposure following inpatient treatment of acute mania with lithium and neuroleptic
Sernyak M, Griffin R, Johnson R, Pearsall H, Wexler B, Woods S. Neuroleptic exposure following inpatient treatment of acute mania with lithium and neuroleptic. American Journal Of Psychiatry 1994, 151: 133-135. PMID: 7903511, DOI: 10.1176/ajp.151.1.133.Peer-Reviewed Original Research
1992
The Outpatient Treatment of Depression
WEXLER B, CICCHETTI D. The Outpatient Treatment of Depression. The Journal Of Nervous And Mental Disease 1992, 180: 277-286. PMID: 1533868, DOI: 10.1097/00005053-199205000-00001.Peer-Reviewed Original ResearchConceptsTreatment failure rateTreatment success rateTreatment dropout ratesInitial treatmentRoutine treatmentOutpatient treatmentEffective treatmentDepressed outpatientsSide effectsClinical practiceCombined treatmentRoutine useIndividual psychotherapyMultiple studiesSuccess rateTreatmentPharmacotherapyModest advantageFailure rateDropout ratePsychotherapyUnnecessary costsPatientsOutpatients
1991
Cerebral laterality, perception of emotion, and treatment response in obsessive-compulsive disorder
Wexler B, Goodman W. Cerebral laterality, perception of emotion, and treatment response in obsessive-compulsive disorder. Biological Psychiatry 1991, 29: 900-908. PMID: 2049488, DOI: 10.1016/0006-3223(91)90056-r.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderEmotion-related wordsNeutral wordsCerebral lateralityLower right-ear advantagesPerception of emotionPositive emotional valenceRight ear advantageDichotic listening testEmotional valenceStimulus pairsOCD patientsListening testsWordsHealthy controlsDepressed patientsSerotonin reuptake inhibitorsLateralityEmotionsDisordersReuptake inhibitorsSevere illnessTreatment responseValencePatientsFailure at task-specific regional brain activation: new conceptualization of a disease entity
Wexler B. Failure at task-specific regional brain activation: new conceptualization of a disease entity. Journal Of Neuropsychiatry 1991, 3: 94-98. PMID: 7580183, DOI: 10.1176/jnp.3.1.94.Peer-Reviewed Original ResearchConceptsNormal brain functionSymptom-based diagnosisRegional brain activationBrain functionBrain activationGroup of patientsCurrent symptom-based diagnosesMultiple brain regionsSpecific anatomic locationsClinical courseEtiologic diagnosisDisease entityAnatomic locationClinical practiceCurrent diagnostic systemsNew treatmentsPathophysiological processesBrain regionsDSM-IIIOrgan systemsDiagnosisBranches of medicinePhysiological dysfunctionNormal functionPatients