2020
Risk‐Taking Patterns of Children, Associated Cognitive Weaknesses, and Prevention of Negative Outcomes
Imal AE, O’Leary S, Wexler BE. Risk‐Taking Patterns of Children, Associated Cognitive Weaknesses, and Prevention of Negative Outcomes. Psychiatric Research And Clinical Practice 2020, 2: 34-40. PMID: 36101890, PMCID: PMC9175884, DOI: 10.1176/appi.prcp.2020.20190020.Peer-Reviewed Original ResearchRisk-taking groupFlanker testWorking Memory TestMemory test scoresEighth-grade childrenTests of inhibitionHealth-compromising behaviorsClusters of childrenCognitive weaknessesMemory testMemory scoresGo/Focused attentionRisk-taking patternsCognitive functionTest measuresNegative outcomesPrimary prevention interventionsTest scoresFull learningReaction timeEarly interventionAvoidantChildrenPrevention interventions
2007
Improved cognitive function in schizophrenia after one year of cognitive training and vocational services
Greig TC, Zito W, Wexler BE, Fiszdon J, Bell MD. Improved cognitive function in schizophrenia after one year of cognitive training and vocational services. Schizophrenia Research 2007, 96: 156-161. PMID: 17669629, PMCID: PMC2080620, DOI: 10.1016/j.schres.2007.07.003.Peer-Reviewed Original ResearchConceptsNeurocognitive enhancement therapyCognitive training exercisesCognitive remediation programNeuropsychological test batterySchizoaffective disorderCognitive trainingExecutive functionEnhancement therapyTest batteryCognitive functionCognitive deficitsRemediation programVocational programsCommunity mental health centerYear-long programMental health centersFeedback groupVocational servicesStable outpatientsParticipantsSchizophreniaTraining exercisesProcessing groupUrban community mental health centerSupport programs
2004
Verbal memory in schizophrenia: additional evidence of subtypes having different cognitive deficits
Bruder GE, Wexler BE, Sage MM, Gil RB, Gorman JM. Verbal memory in schizophrenia: additional evidence of subtypes having different cognitive deficits. Schizophrenia Research 2004, 68: 137-147. PMID: 15099598, DOI: 10.1016/s0920-9964(03)00156-7.Peer-Reviewed Original ResearchMeSH KeywordsAdultAttentionAuditory PerceptionCerebral CortexCognition DisordersDichotic Listening TestsDominance, CerebralFemaleFunctional LateralityHumansMaleMemory DisordersMental RecallNeuropsychological TestsPaired-Associate LearningPitch DiscriminationPsychiatric Status Rating ScalesSchizophreniaSchizophrenic PsychologyVerbal LearningWechsler ScalesConceptsVerbal memory deficitsMemory deficitsVerbal memoryWechsler Memory Scale-RevisedNonverbal cognitive functionsDifferent cognitive deficitsSerial position effectsVerbal materialVisual memoryNonverbal testsAuditory perceptionGeneralized deficitSelective deficitDichotic wordsHemispheric dominanceCognitive deficitsCognitive functionMemoryMedication statusHealthy controlsDeficitsOverall poor performancePosition effectsPoor performancePosition testEffects of neurocognitive enhancement therapy in schizophrenia: Normalisation of memory performance
Bell MD, Fiszdon J, Bryson G, Wexler BE. Effects of neurocognitive enhancement therapy in schizophrenia: Normalisation of memory performance. Cognitive Neuropsychiatry 2004, 9: 199-211. PMID: 16571581, DOI: 10.1080/13546800344000084.Peer-Reviewed Original ResearchNeurocognitive enhancement therapyMemory taskReaction time taskCognitive remediationTime taskSchizophrenia patientsEnhancement therapyCommunity control samplePreponderance of researchCognitive trainingWord recallDigit recallMemory performanceCognitive performanceCognitive functionSchizophrenia sampleNonpsychiatric controlsTaskReaction timePoor performanceRecallCommunity controlsHierarchical trainingSchizophreniaTraining
2001
Effects of Smoking Abstinence on Visuospatial Working Memory Function in Schizophrenia
George TP, Vessicchio JC, Termine A, Sahady DM, Head CA, Pepper WT, Kosten TR, Wexler BE. Effects of Smoking Abstinence on Visuospatial Working Memory Function in Schizophrenia. Neuropsychopharmacology 2001, 26: 75-85. PMID: 11751034, DOI: 10.1016/s0893-133x(01)00296-2.Peer-Reviewed Original ResearchConceptsVisuospatial working memorySmoking abstinenceStroop Color-Word TestAbstinence-induced changesWorking Memory FunctionColor-Word TestPlacebo-controlled smoking cessation trialFunction of genderWorking memoryCigarette smokingWord TestSmoking cessation trialCognitive functionCognitive deficitsMemory functionNicotine-dependent cigarette smokersNon-smoking controlsSignificant impairmentPathophysiology of schizophreniaDopamine functionCortical dopamine functionCessation trialSchizophrenic smokersDepressive symptomsAbstinence
1998
Word and Tone Working Memory Deficits in Schizophrenia
Wexler BE, Stevens AA, Bowers AA, Sernyak MJ, Goldman-Rakic PS. Word and Tone Working Memory Deficits in Schizophrenia. JAMA Psychiatry 1998, 55: 1093-1096. PMID: 9862552, DOI: 10.1001/archpsyc.55.12.1093.Peer-Reviewed Original ResearchConceptsMemory testNonverbal testsVerbal testsMemory deficitsSerial position taskTests of perceptionAuditory memory testVerbal memory deficitsWorking Memory DeficitsImmediate recall taskSignificant performance deficitsRecall taskVerbal memoryPerceptual functionsSustained attentionDiscrimination taskPitch discriminationSelective deficitNormal motivationPerformance deficitsPosition taskMemory testingCognitive functionMedicated outpatientsInformation processingCortical Dysfunction in Schizophrenia During Auditory Word and Tone Working Memory Demonstrated by Functional Magnetic Resonance Imaging
Stevens AA, Goldman-Rakic PS, Gore JC, Fulbright RK, Wexler BE. Cortical Dysfunction in Schizophrenia During Auditory Word and Tone Working Memory Demonstrated by Functional Magnetic Resonance Imaging. JAMA Psychiatry 1998, 55: 1097-1103. PMID: 9862553, DOI: 10.1001/archpsyc.55.12.1097.Peer-Reviewed Original ResearchConceptsSerial position taskFunctional magnetic resonance imagingInferior frontal gyrusPosition taskMemory deficitsFrontal gyrusLeft inferior frontal gyrusAnterior temporal lobe areasTask-specific activationFunctional magnetic resonanceSpeech-related areasCortical hemodynamic responsesTemporal lobe areasSevere cognitive deficitsAuditory wordsWorking memoryVerbal learningNeural basisSuch deficitsCognitive deficitsCognitive functionParietal lobeLobe areasMagnetic resonance imagingCognitive dysfunction