2007
Monocyte Activation in On-Pump Versus Off-Pump Coronary Artery Bypass Surgery
Greilich PE, Brouse CF, Rinder HM, Jessen ME, Rinder CS, Eberhart RC, Whitten CW, Smith BR. Monocyte Activation in On-Pump Versus Off-Pump Coronary Artery Bypass Surgery. Journal Of Cardiothoracic And Vascular Anesthesia 2007, 22: 361-368. PMID: 18503922, DOI: 10.1053/j.jvca.2007.08.009.Peer-Reviewed Original ResearchConceptsPump CABG surgeryCABG surgeryMonocyte activationPump CABGPump Versus Off-Pump Coronary Artery Bypass SurgeryOff-pump coronary artery bypass surgeryPump coronary artery bypass graft surgeryCoronary artery bypass graft surgeryOff-pump CABG surgeryArtery bypass graft surgeryCoronary artery bypass surgeryMonocyte CD11b expressionPrimary CABG surgeryBypass graft surgeryArtery bypass surgerySystemic inflammatory responseVeterans Affairs hospitalInterleukin levelsSurgery warrantsGraft surgeryAdverse eventsBypass surgeryHeparin reversalPathophysiologic differencesAntifibrinolytic agentsFlow cytometric analysis of myelomonocytic cells by a pattern recognition approach is sensitive and specific in diagnosing myelodysplastic syndrome and related marrow diseases: Emphasis on a global evaluation and recognition of diagnostic pitfalls
Stachurski D, Smith BR, Pozdnyakova O, Andersen M, Xiao Z, Raza A, Woda BA, Wang A. Flow cytometric analysis of myelomonocytic cells by a pattern recognition approach is sensitive and specific in diagnosing myelodysplastic syndrome and related marrow diseases: Emphasis on a global evaluation and recognition of diagnostic pitfalls. Leukemia Research 2007, 32: 215-224. PMID: 17675229, DOI: 10.1016/j.leukres.2007.06.012.Peer-Reviewed Original ResearchConceptsMyelodysplastic syndromeFlow cytometryDiagnostic pitfallsMyelomonocytic cellsMDS/MPDClonal cytogenetic abnormalitiesGlobal evaluationImmunophenotypic aberranciesRetrospective reviewMorphological dysplasiaMarrow diseaseMyeloproliferative diseaseDiagnostic utilityCytogenetic abnormalitiesDisease casesMyeloid diseasesCytometric analysisOverall sensitivityAbnormalitiesDiseaseOverall abnormalitySyndromeIntermediate category
2006
Antithrombin reduces monocyte and neutrophil CD11b up regulation in addition to blocking platelet activation during extracorporeal circulation
Rinder CS, Rinder HM, Smith MJ, Fitch JC, Tracey JB, Chandler WL, Rollins SA, Smith BR. Antithrombin reduces monocyte and neutrophil CD11b up regulation in addition to blocking platelet activation during extracorporeal circulation. Transfusion 2006, 46: 1130-1137. PMID: 16836559, DOI: 10.1111/j.1537-2995.2006.00861.x.Peer-Reviewed Original ResearchConceptsNeutrophil elastase releaseAnti-inflammatory activityAntithrombin IIICardiopulmonary bypassElastase releasePlatelet activationWhite blood cell activationDirect anti-inflammatory activitySystemic inflammatory reactionAbsence of endotheliumEndothelial effectsCardiac surgeryBlood cell activationAnticoagulant effectExtracorporeal circulationInflammatory reactionThrombin generationHigh doseClinical relevanceCell activationFibrin generationComplement activationThrombin activityStudy designCD11b
2005
Atrial Fibrillation After Cardiac Surgery/Cardiopulmonary Bypass Is Associated with Monocyte Activation
Fontes ML, Mathew JP, Rinder HM, Zelterman D, Smith BR, Rinder CS. Atrial Fibrillation After Cardiac Surgery/Cardiopulmonary Bypass Is Associated with Monocyte Activation. Anesthesia & Analgesia 2005, 101: 17-23. PMID: 15976199, DOI: 10.1213/01.ane.0000155260.93406.29.Peer-Reviewed Original ResearchConceptsPostoperative atrial fibrillationC-reactive proteinPreoperative C-reactive proteinCardiopulmonary bypassAtrial fibrillationCardiac surgerySinus rhythmAortic cross-clamp releaseTroponin IPilot studyCross-clamp releaseSubset of patientsCardiac muscle damageNormal sinus rhythmLeukocyte inflammatory responsesExploratory pilot studyPMN CD11bCPB patientsInflammatory infiltrationPMN countCD11b upregulationCellular inflammationInflammatory responseMonocyte activationMuscle damage
2003
Increased leukocyte-platelet adhesion in patients with graft occlusion after peripheral vascular surgery
Esposito CJ, Popescu WM, Rinder HM, Schwartz JJ, Smith BR, Rinder CS. Increased leukocyte-platelet adhesion in patients with graft occlusion after peripheral vascular surgery. Thrombosis And Haemostasis 2003, 90: 1128-1134. PMID: 14652647, DOI: 10.1160/th03-04-0226.Peer-Reviewed Original ResearchConceptsPeripheral vascular diseasePeripheral vascular surgeryGraft occlusionLeukocyte-platelet adhesionOcclusion groupPlatelet turnoverVascular surgeryPMN activationPeripheral vascular surgery patientsLower extremity peripheral vascular diseaseEtiology of thrombosisVascular surgery patientsLate graft occlusionEarly postoperative periodSurface CD11b expressionProgression of atherosclerosisGraft lossPVD patientsGraft patientsPostoperative dayPostoperative periodSurgery patientsAcute thrombosisGraft patencyVascular disease
1997
Lymphocyte and monocyte subset changes during cardiopulmonary bypass: Effects of aging and gender
Rinder C, Mathew J, Rinder H, Tracey J, Davis E, Smith B. Lymphocyte and monocyte subset changes during cardiopulmonary bypass: Effects of aging and gender. Translational Research 1997, 129: 592-602. PMID: 9178725, DOI: 10.1016/s0022-2143(97)90193-1.Peer-Reviewed Original ResearchConceptsCardiopulmonary bypassOlder patientsT cellsLower lymphocyte numbersPercentage of CD8Total lymphocyte countCardiac surgery patientsPostoperative day 1Age of patientsMononuclear cell subsetsNatural killer cellsExpression of CD11bPatterns of lymphocytesYears of ageEvidence of activationHLADR expressionInfectious complicationsLymphocyte subsetsElderly patientsLymphocyte countSurgery patientsYounger patientsCardiac surgeryLymphocyte numbersKiller cells
1994
Neutrophil but not Monocyte Activation Inhibits P-Selectin-Mediated Platelet Adhesion*
Rinder H, Tracey J, Rinder C, Leitenberg D, Smith B. Neutrophil but not Monocyte Activation Inhibits P-Selectin-Mediated Platelet Adhesion*. Thrombosis And Haemostasis 1994, 72: 750-756. PMID: 7534948, DOI: 10.1055/s-0038-1648953.Peer-Reviewed Original ResearchConceptsNeutrophil-platelet conjugatesP-selectinP-selectin-mediated platelet adhesionDREG-56Platelet activationL-selectinPlatelet P-selectin expressionP-selectin-expressing plateletsP-selectin-positive plateletsLeukocyte-platelet conjugatesNeutrophil-platelet adhesionPlatelet P-selectinP-selectin expressionWhole blood modelLeukocyte-platelet adhesionPlatelet adhesionNeutrophil activationLeukocyte activationNeutrophil adhesionBaseline levelsNeutrophilsUnstimulated leukocytesMonoclonal antibodiesEndothelial cellsImmediate rise
1992
Cardiopulmonary Bypass Induces Leukocyte-Platelet Adhesion
Rinder C, Bonan J, Rinder H, Mathew J, Hines R, Smith B. Cardiopulmonary Bypass Induces Leukocyte-Platelet Adhesion. Blood 1992, 79: 1201-1205. PMID: 1371416, DOI: 10.1182/blood.v79.5.1201.1201.Peer-Reviewed Original ResearchConceptsLeukocyte-platelet conjugatesCardiopulmonary bypassMonocyte-platelet conjugatesEnd of CPBStart of CPBActivation of monocytesAlpha-granule releaseGMP-140 expressionGranule membrane protein-140Time courseLeukocyte-platelet adhesionCD11b expressionMonocyte activationSurface CD11bWhole bloodGMP-140Surface expressionProtein 140Increased numberCD11bBypassMonocytesPlateletsPlatelet adhesionConjugates
1991
Dynamics of leukocyte-platelet adhesion in whole blood.
Rinder H, Bonan J, Rinder C, Ault K, Smith B. Dynamics of leukocyte-platelet adhesion in whole blood. Blood 1991, 78: 1730-7. PMID: 1717069, DOI: 10.1182/blood.v78.7.1730.bloodjournal7871730.Peer-Reviewed Original ResearchActivated and unactivated platelet adhesion to monocytes and neutrophils.
Rinder H, Bonan J, Rinder C, Ault K, Smith B. Activated and unactivated platelet adhesion to monocytes and neutrophils. Blood 1991, 78: 1760-9. PMID: 1717070, DOI: 10.1182/blood.v78.7.1760.bloodjournal7871760.Peer-Reviewed Original Research
1983
Cells on microspheres: A new technique for flow cytometric analysis of adherent cells
Bloch D, Smith B, Ault K. Cells on microspheres: A new technique for flow cytometric analysis of adherent cells. Cytometry 1983, 3: 449-452. PMID: 6343013, DOI: 10.1002/cyto.990030611.Peer-Reviewed Original Research
1981
Increase of surface Ia-like antigen expression on human monocytes independent of antigenic stimuli.
Smith BR, Ault KA. Increase of surface Ia-like antigen expression on human monocytes independent of antigenic stimuli. The Journal Of Immunology 1981, 127: 2020-7. PMID: 6170685, DOI: 10.4049/jimmunol.127.5.2020.Peer-Reviewed Original Research