2004
Effects of ε-Aminocaproic Acid and Aprotinin on Leukocyte–Platelet Adhesion in Patients Undergoing Cardiac Surgery
Greilich PE, Brouse CF, Rinder CS, Smith BR, Sandoval BA, Rinder HM, Eberhart RC, Jessen ME. Effects of ε-Aminocaproic Acid and Aprotinin on Leukocyte–Platelet Adhesion in Patients Undergoing Cardiac Surgery. Anesthesiology 2004, 100: 225-233. PMID: 14739793, DOI: 10.1097/00000542-200402000-00008.Peer-Reviewed Original ResearchConceptsEpsilon-aminocaproic acidCardiopulmonary bypassLeukocyte-platelet adhesionPlatelet activationPlatelet CD62PCardiac surgeryPlasmin activityAdministration of aprotininDouble-blind fashionMonocyte-platelet conjugatesActivation of leukocytesD-dimer formationConjugate formationAbility of aprotininMonocyte CD11bSaline groupCD11b expressionLeukocyte activationΕ-aminocaproic acidPatientsUseful markerClinical settingAprotininLeukocytesSurgery
1995
Acadesine inhibits neutrophil CD11b up-regulation in vitro and during in vivo cardiopulmonary bypass
Mathew J, Rinder C, Tracey J, Auszura L, O'Connor T, Davis E, Smith B. Acadesine inhibits neutrophil CD11b up-regulation in vitro and during in vivo cardiopulmonary bypass. Journal Of Thoracic And Cardiovascular Surgery 1995, 109: 448-456. PMID: 7877305, DOI: 10.1016/s0022-5223(95)70275-x.Peer-Reviewed Original ResearchConceptsGranulocyte CD11bCardiopulmonary bypassReperfusion injuryIschemic tissueHigh-dose treatment groupVivo reperfusion injuryGranulocyte CD11b expressionCD11b/CD18Acadesine groupMulticenter trialCD11b expressionAdenosine levelsTreatment groupsAnimal modelsCD11bControl diluentAcadesineBypassInjuryWhole bloodGranulocyte adhesionSimilar inhibitionVivo trialsPatientsTrials
1994
Platelet-leukocyte activation and modulation of adhesion receptors in pediatric patients with congenital heart disease undergoing cardiopulmonary bypass
Rinder C, Gaal D, Student L, Smith B. Platelet-leukocyte activation and modulation of adhesion receptors in pediatric patients with congenital heart disease undergoing cardiopulmonary bypass. Journal Of Thoracic And Cardiovascular Surgery 1994, 107: 280-288. PMID: 8283897, DOI: 10.1016/s0022-5223(94)70482-1.Peer-Reviewed Original ResearchConceptsCongenital heart diseasePlatelet-leukocyte conjugatesNoncyanotic congenital heart diseaseCardiopulmonary bypassHeart diseasePediatric patientsNoncyanotic patientsLeukocyte activationPlatelet glycoprotein IbNeutrophil-platelet conjugatesPlatelet–leukocyte activationTermination of bypassCyanotic heart diseaseEnd of bypassMonocyte-platelet conjugatesGlycoprotein IbNoncyanotic heart diseaseActivation of plateletsInflammatory complicationsPulmonary dysfunctionCyanotic patientsPlatelet adhesion receptorsCD11b expressionClinical riskBaseline values
1992
Cardiopulmonary Bypass Induces Leukocyte-Platelet Adhesion
Rinder C, Bonan J, Rinder H, Mathew J, Hines R, Smith B. Cardiopulmonary Bypass Induces Leukocyte-Platelet Adhesion. Blood 1992, 79: 1201-1205. PMID: 1371416, DOI: 10.1182/blood.v79.5.1201.1201.Peer-Reviewed Original ResearchConceptsLeukocyte-platelet conjugatesCardiopulmonary bypassMonocyte-platelet conjugatesEnd of CPBStart of CPBActivation of monocytesAlpha-granule releaseGMP-140 expressionGranule membrane protein-140Time courseLeukocyte-platelet adhesionCD11b expressionMonocyte activationSurface CD11bWhole bloodGMP-140Surface expressionProtein 140Increased numberCD11bBypassMonocytesPlateletsPlatelet adhesionConjugatesCardiopulmonary bypass induces leukocyte-platelet adhesion
Rinder C, Bonan J, Rinder H, Mathew J, Hines R, Smith B. Cardiopulmonary bypass induces leukocyte-platelet adhesion. Blood 1992, 79: 1201-1205. DOI: 10.1182/blood.v79.5.1201.bloodjournal7951201.Peer-Reviewed Original ResearchLeukocyte-platelet conjugatesCardiopulmonary bypassMonocyte-platelet conjugatesEnd of CPBStart of CPBActivation of monocytesAlpha-granule releaseGMP-140 expressionGranule membrane protein-140Time courseLeukocyte-platelet adhesionCD11b expressionMonocyte activationSurface CD11bWhole bloodGMP-140Surface expressionProtein 140Increased numberCD11bBypassMonocytesPlateletsPlatelet adhesionConjugates