Brian Leaderer, MPH, PhD
Susan Dwight Bliss Professor Emeritus of Epidemiology (Environmental Health Sciences)Cards
Additional Titles
Affiliated Faculty, Yale Institute for Global Health
Senior Research Scientist, Yale Center for Perinatal, Pediatric and Environmental Epidemiology, Environmental Health Sciences
Contact Info
Environmental Health Sciences
PO Box 208034, 60 College Street
New Haven, CT 06520-8034
United States
About
Titles
Susan Dwight Bliss Professor Emeritus of Epidemiology (Environmental Health Sciences)
Affiliated Faculty, Yale Institute for Global Health; Senior Research Scientist, Yale Center for Perinatal, Pediatric and Environmental Epidemiology, Environmental Health Sciences
Biography
Dr. Brian Leaderer is the Susan Dwight Bliss Professor Emeritus of Epidemiology in the Department of Environmental Health Sciences at the Yale School of Public Health and Professor Emeritus of the Yale School of the Environment. He is also a Senior Research Scientist at the Yale Center for Perinatal, Pediatric and Environmental Epidemiology (the Yale CPPEE, or the "Center"), which he co-directed for 18 years. In his role as the Deputy Dean at the Yale School of Public Health for over 14 years (during which he was also Interim Dean for 2 years), he oversaw Faculty Affairs including the Appointments and Promotion Committee and Faculty Mentoring Program. He has served on several Committees and Review Panels (NRC, EPA, HEI, etc.).
Dr. Leaderer's research interests, resulting in over 300 publications, are interdisciplinary in nature with a focus on assessing exposures (measured and modeled in both environmental chamber and field studies) to air contaminants (indoor and outdoor) and assessing the health impact resulting from those exposures in epidemiological studies. Over the past 30 years, he has been Principal Investigator on numerous research grants (totaling approximately $40 million). Several of these grants have been large epidemiologic-based grants (R01s) centered on the role of environmental and genetic factors on the respiratory health of children with particular attention to their role in the development of asthma and asthma severity. He has collaborated with colleagues from several disciplines at the Yale CPPEE for over 30 years on several epidemiologic studies examining the impact of pollutants on perinatal and pediatric outcomes. With funding from the National Institute of Environmental Health Sciences (NIEHS), he investigated the relationship between exposures to indoor levels of nitrogen dioxide, traffic contaminants, and the exacerbation of asthma in 1,401 children (in the STAR Study). The findings from this study resulted in another NIH-funded (NIEHS) grant to conduct a double-blind, randomized control, triple cross-over design intervention trial in urban homes of asthmatic children to examine the efficacy of reducing exposure to indoor levels of PM2.5 and NO2 on reducing asthma severity.
Appointments
Environmental Health Sciences
EmeritusPrimaryEnvironmental Health Sciences
Senior Research ScientistSecondary
Other Departments & Organizations
Education & Training
- PhD
- Yale University, Environmental Epidemiology (1975)
- MPH
- Yale University, Environmental Health (1971)
Research
Overview
- Traffic and Respiratory Health
- Indoor and Outdoor NO2 and Asthma Severity in Children
- Asthma Severity in Children and Fine Particle Composition
- Gene-Environment Interactions in Asthma Development
- Genetic and Environmental Risk Factors in Asthma Severity
- The Yale Center for Public Health Preparedness.
Medical Subject Headings (MeSH)
- View Lab Website
Yale Center for Perinatal, Pediatric and Environmental Epidemiology (CPPEE)
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Michael B. Bracken, PhD, MPH, FACE
Theodore Holford, PhD
Elizabeth Triche
Michelle L. Bell, PhD
Julie Plano
Nicole Deziel, PhD, MHS
Asthma
Environmental Exposure
Air Pollution, Indoor
Air Pollution
Public Health
Environmental Health
Publications
2023
Assessment of children's personal and land use regression model-estimated exposure to NO2 in Springfield, Massachusetts
Gao D, Esenther S, Minet L, De Jesus A, Hudson S, Leaderer B, Hatzopoulou M, Godri Pollitt K. Assessment of children's personal and land use regression model-estimated exposure to NO2 in Springfield, Massachusetts. The Science Of The Total Environment 2023, 892: 164681. PMID: 37302586, DOI: 10.1016/j.scitotenv.2023.164681.Peer-Reviewed Original ResearchPaired Indoor and Outdoor Nitrogen Dioxide Associated With Childhood Asthma Outcomes in a Mixed Rural-Urban Setting: A Feasibility Study
Wi C, Gent J, Bublitz J, King K, Ryu E, Sorrentino K, Plano J, McKay L, Porcher J, Wheeler P, Chiarella S, DeWan A, Pollitt K, Sheares B, Leaderer B, Juhn Y. Paired Indoor and Outdoor Nitrogen Dioxide Associated With Childhood Asthma Outcomes in a Mixed Rural-Urban Setting: A Feasibility Study. Journal Of Primary Care & Community Health 2023, 14: 21501319231173813. PMID: 37243352, PMCID: PMC10226331, DOI: 10.1177/21501319231173813.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsAsthma control statusControl statusAsthma diaryRural-urban settingOutdoor NOChildhood asthma outcomesProspective cohort studySocioeconomic statusLow socioeconomic statusSmall feasibility studyAsthma exacerbationsOlmsted CountyPersistent asthmaAsthma outcomesCohort studyChildhood asthmaRural-urban communityLarger sample sizeAsthmaStudy periodHealth effectsFeasibility studyWeeksStatusLow threshold
2022
Childhood asthma and household exposures to nitrogen dioxide and fine particles: a triple-crossover randomized intervention trial
Gent JF, Holford TR, Bracken MB, Plano JM, McKay LA, Sorrentino KM, Koutrakis P, Leaderer BP. Childhood asthma and household exposures to nitrogen dioxide and fine particles: a triple-crossover randomized intervention trial. Journal Of Asthma 2022, 60: 744-753. PMID: 35796019, PMCID: PMC10162040, DOI: 10.1080/02770903.2022.2093219.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsLevels of NOPersistent asthmaAsthma symptomsIntervention trialsNumber of asthmaDays of treatmentSymptom daysAsthma morbidityChildhood asthmaTreatment periodAsthmaCrossover designHousehold exposureSymptomsModest reductionTreatment effectsTreatmentGas stovesTrialsExposureTriple crossoverInterventionChildrenMixed modelsFurther research
2019
Spatiotemporal calibration of atmospheric nitrogen dioxide concentration estimates from an air quality model for Connecticut
Gilani O, McKay L, Gregoire T, Guan Y, Leaderer B, Holford T. Spatiotemporal calibration of atmospheric nitrogen dioxide concentration estimates from an air quality model for Connecticut. Environmental And Ecological Statistics 2019, 26: 325-349. DOI: 10.1007/s10651-019-00430-7.Peer-Reviewed Original ResearchAltmetricConceptsAir quality modelsCommunity Multiscale Air Quality (CMAQ) modelMultiscale Air Quality modelQuality modelCMAQ model estimatesSpatial resolutionLand use characteristicsContribution of trafficConcentrations of ambientSpatial resolution mapsLocal covariatesFine spatial resolution mapsSpatiotemporal calibrationModel estimatesDioxide concentrationNitrogen dioxide concentrationsConcentration estimatesTemporal resolutionDaily concentrationsResolution mapsPrediction mapsSimilar mapsMonitor sitesMajor highwaysUse characteristics
2018
Residential Proximity to Unconventional Oil and Gas Development and Air Volatile Organic Compound Concentrations in Ohio
Elliott E, Wang C, McKay L, Pedersen C, Gerber C, Leaderer B, Plata D, Deziel N. Residential Proximity to Unconventional Oil and Gas Development and Air Volatile Organic Compound Concentrations in Ohio. ISEE Conference Abstracts 2018, 2018 DOI: 10.1289/isesisee.2018.p02.2040.Peer-Reviewed Original ResearchA community-based evaluation of proximity to unconventional oil and gas wells, drinking water contaminants, and health symptoms in Ohio
Elliott EG, Ma X, Leaderer BP, McKay LA, Pedersen CJ, Wang C, Gerber CJ, Wright TJ, Sumner AJ, Brennan M, Silva GS, Warren JL, Plata DL, Deziel NC. A community-based evaluation of proximity to unconventional oil and gas wells, drinking water contaminants, and health symptoms in Ohio. Environmental Research 2018, 167: 550-557. PMID: 30145431, DOI: 10.1016/j.envres.2018.08.022.Peer-Reviewed Original ResearchCitationsAltmetricExperimental Considerations in the Measurement of Exposures to Sidestream Cigarette Smoke
Stolwijk J, Leaderer B, Leaderer M, Pierce J. Experimental Considerations in the Measurement of Exposures to Sidestream Cigarette Smoke. 2018, 205-214. DOI: 10.1201/9781351073479-19.Chapters
2017
Investigating the Impact of Maternal Residential Mobility on Identifying Critical Windows of Susceptibility to Ambient Air Pollution During Pregnancy
Warren JL, Son JY, Pereira G, Leaderer BP, Bell ML. Investigating the Impact of Maternal Residential Mobility on Identifying Critical Windows of Susceptibility to Ambient Air Pollution During Pregnancy. American Journal Of Epidemiology 2017, 187: 992-1000. PMID: 29053768, PMCID: PMC5928458, DOI: 10.1093/aje/kwx335.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsLow birth weightTerm low birth weightMaternal residential mobilityBirth weightCritical windowBirth cohortWeekly exposurePregnancy week 16Adverse birth outcomesWindow of susceptibilityAmbient air pollutionPregnancy windowsBirth outcomesWeek 16Mother's residencePM10 exposurePregnancyResidential addressesExposure misclassificationDisease developmentCohortAir pollutionExposureAerodynamic diameterPossible mechanismTraffic‐related air pollution associations with cytokeratin‐18, a marker of hepatocellular apoptosis, in an overweight and obese paediatric population
Hsieh S, Leaderer BP, Feldstein AE, Santoro N, McKay LA, Caprio S, McConnell R. Traffic‐related air pollution associations with cytokeratin‐18, a marker of hepatocellular apoptosis, in an overweight and obese paediatric population. Pediatric Obesity 2017, 13: 342-347. PMID: 28730729, PMCID: PMC5775922, DOI: 10.1111/ijpo.12228.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsNon-alcoholic fatty liver diseaseTraffic-related air pollutionNon-alcoholic steatohepatitisHepatic fat fractionCK-18Pre-existing non-alcoholic fatty liver diseaseCytokeratin 18Fatty liver diseaseObese pediatric populationPediatric obesity clinicNitrogen dioxide exposureMagnetic resonance imagingObesity clinicStudy entryFatty liverLiver diseaseObese childrenPediatric populationLiver enzymesLiver susceptibilityHepatocellular apoptosisAnimal modelsResidential buffersResonance imagingAir pollution associationsNIAID, NIEHS, NHLBI, and MCAN Workshop Report: The indoor environment and childhood asthma—implications for home environmental intervention in asthma prevention and management
Gold DR, Adamkiewicz G, Arshad SH, Celedón JC, Chapman MD, Chew GL, Cook DN, Custovic A, Gehring U, Gern JE, Johnson CC, Kennedy S, Koutrakis P, Leaderer B, Mitchell H, Litonjua AA, Mueller GA, O'Connor GT, Ownby D, Phipatanakul W, Persky V, Perzanowski MS, Ramsey CD, Salo PM, Schwaninger JM, Sordillo JE, Spira A, Suglia SF, Togias A, Zeldin DC, Matsui EC. NIAID, NIEHS, NHLBI, and MCAN Workshop Report: The indoor environment and childhood asthma—implications for home environmental intervention in asthma prevention and management. Journal Of Allergy And Clinical Immunology 2017, 140: 933-949. PMID: 28502823, PMCID: PMC5632590, DOI: 10.1016/j.jaci.2017.04.024.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAir Pollution, IndoorAnimalsAsthmaBiomedical ResearchChildConsensus Development Conferences, NIH as TopicDrug IndustryEnvironmental HealthFund RaisingHumansNational Heart, Lung, and Blood Institute (U.S.)National Institute of Allergy and Infectious Diseases (U.S.)National Institute of Environmental Health Sciences (U.S.)Organizations, NonprofitUnited StatesConceptsEnvironmental exposuresCommon chronic childhood diseaseEnvironmental interventionsMerck Childhood Asthma NetworkControl of asthmaExacerbation of asthmaManagement of asthmaChronic childhood diseaseHome environmental interventionsExposure reduction techniquesNational InstituteAirway allergyAsthma preventionAsthma managementAsthma NetworkBlood InstituteChildhood asthmaNational HeartChildhood diseasesAsthmaEnvironmental Health SciencesInfectious diseasesStudy designBiologic propertiesIndoor exposure
Academic Achievements and Community Involvement
activity NIAID, Inner City Asthma Consortium External Scientific Advisory Group
Professional OrganizationsMemberDetails2009 - Presentactivity Several advisory groups for the U.S. EPA
Professional OrganizationsMemberDetails1991 - Presentactivity Board of Directors of International Society of Exposure Analysis
Professional OrganizationsMemberDetails1989 - Presentactivity Several World Health Organization Committees on Indoor Air Quality including Biological Contaminants and Combustion Source Contaminants
Professional OrganizationsMemberDetails1988 - Presentactivity Science Advisory Board, U.S. EPA; Board Committees: Review of Clinical Research Program, Exposure Assessment Committee, Future Research Needs in the '90s, Health Research Needs and Scientific and Technological Achievement Awards Committees, Indoor Air Quality and Total Human Exposure Assessment Committee
Professional OrganizationsMemberDetails1985 - Present
Links & Media
News
- May 16, 2023
Nicole Deziel named co-director of the Yale Center for Perinatal, Pediatric, and Environmental Epidemiology
- May 02, 2022
Yale Center For Perinatal, Pediatric, and Environmental Epidemiology Hunts Through History to Answer Tomorrow's Research Questions
- May 02, 2022
Snapshots
- March 07, 2021
Responding to a Changing World Alumni Spotlight: Dr. Katherine Ciacco Palatianos
Related Links
Get In Touch
Contacts
Environmental Health Sciences
PO Box 208034, 60 College Street
New Haven, CT 06520-8034
United States
Locations
Yale Center for Perinatal, Pediatric and Environmental Epidemiology (CPPEE)
Academic Office
1 Church Street, Ste 6th Floor
New Haven, CT 06510