2023
The connection still matters: Therapeutic alliance with digital treatment for alcohol use disorder
Benitez B, Frankforter T, Nich C, Kiluk B. The connection still matters: Therapeutic alliance with digital treatment for alcohol use disorder. Alcohol Clinical And Experimental Research 2023, 47: 2197-2207. PMID: 38226756, PMCID: PMC10792249, DOI: 10.1111/acer.15199.Peer-Reviewed Original ResearchWorking Alliance InventoryAlliance ratingsAlcohol useMinimal clinical monitoringOutpatient AUD treatmentPatient-reported measuresAlcohol use disorderDisorder treatment outcomesDaily alcohol useCognitive behavioral therapy programBehavioral therapy programAlcohol use disorder treatment outcomesClinical trialsTreatment outcomesFuture drinkingUse disordersTreatment efficacyTreatment sessionsAUD treatmentClinical monitoringComputerized cognitive behavioural therapy programmeTherapy programFuture alcohol useTherapeutic allianceAlliance InventoryDistinct neural networks predict cocaine versus cannabis treatment outcomes
Lichenstein S, Kohler R, Ye F, Potenza M, Kiluk B, Yip S. Distinct neural networks predict cocaine versus cannabis treatment outcomes. Molecular Psychiatry 2023, 28: 3365-3372. PMID: 37308679, PMCID: PMC10713861, DOI: 10.1038/s41380-023-02120-0.Peer-Reviewed Original ResearchConceptsConnectome-based predictive modelingCognitive behavior therapyCognitive behavioral therapySubstance use disordersCannabis abstinenceNeural mechanismsBehavior therapyDistinct neural networksComputer-based trainingCannabis use disorderFMRI scanningNeural predictorsStudy 1Study 2Treatment outcomesContingency managementPrior workComparison subjectsNetwork strengthUse disordersNovel treatment targetsAbstinenceIndependent samplesCocaine abstinenceTreatment respondersEfficacy of Cognitive Behavioral Therapy for Alcohol and Other Drug Use Disorders: Is a One-Size-Fits-All Approach Appropriate?
Magill M, Kiluk B, Ray L. Efficacy of Cognitive Behavioral Therapy for Alcohol and Other Drug Use Disorders: Is a One-Size-Fits-All Approach Appropriate? Substance Abuse And Rehabilitation 2023, 14: 1-11. PMID: 36844999, PMCID: PMC9948631, DOI: 10.2147/sar.s362864.Peer-Reviewed Original ResearchUsual care control conditionCare control conditionDrug use disordersUse disordersEvidence-based treatmentsCognitive behavioral therapyMechanism of actionCBT effectsControl conditionDemonstrated efficacyCBT efficacyForm of CBTBehavioral therapyTherapy efficacyAdult alcoholAOD useMotivational interviewingNarrative overviewContingency managementEfficacyIntervention outcomesTraditional CBTCBTPreliminary evidenceEffect sizeClinical Trial Design Challenges and Opportunities for Emerging Treatments for Opioid Use Disorder
Kiluk B, Kleykamp B, Comer S, Griffiths R, Huhn A, Johnson M, Kampman K, Pravetoni M, Preston K, Vandrey R, Bergeria C, Bogenschutz M, Brown R, Dunn K, Dworkin R, Finan P, Hendricks P, Houtsmuller E, Kosten T, Lee D, Levin F, McRae-Clark A, Raison C, Rasmussen K, Turk D, Weiss R, Strain E. Clinical Trial Design Challenges and Opportunities for Emerging Treatments for Opioid Use Disorder. JAMA Psychiatry 2023, 80: 84-92. PMID: 36449315, PMCID: PMC10297827, DOI: 10.1001/jamapsychiatry.2022.4020.Peer-Reviewed Original ResearchConceptsOpioid use disorderOUD treatmentUse disordersClinical trial design challengesAddiction Clinical Trial TranslationsΜ-opioid receptor systemNetworks (ACTTION) public-private partnershipTrial design challengesOngoing opioid epidemicTrial design considerationsClinical trial design considerationsRole of treatmentQuality of lifeAntagonist medicationsEmerging TreatmentsAdverse eventsOpioid usePrimary outcomeStages of treatmentPatient preferencesMOR agonistsOpioid epidemicConsensus recommendationsCurrent evidenceTreatment retentionPromoting alcohol treatment engagement post-hospitalization with brief intervention, medications and CBT4CBT: protocol for a randomized clinical trial in a diverse patient population
Edelman E, Rojas-Perez O, Nich C, Corvino J, Frankforter T, Gordon D, Jordan A, Paris, Jr M, Weimer M, Yates B, Williams E, Kiluk B. Promoting alcohol treatment engagement post-hospitalization with brief intervention, medications and CBT4CBT: protocol for a randomized clinical trial in a diverse patient population. Addiction Science & Clinical Practice 2023, 18: 55. PMID: 37726823, PMCID: PMC10510167, DOI: 10.1186/s13722-023-00407-9.Peer-Reviewed Original ResearchConceptsPost-hospital dischargeCognitive behavioral therapySelf-reported alcohol useBrief Negotiation InterviewUse disordersAlcohol use outcomesComputer-based trainingDays post-hospital dischargeAlcohol use disorderBehavioral therapyInitiation of medicationHealth care utilizationHealth promotion advocatesTreatment engagementUse outcomesAlcohol useSecondary outcomesHospitalized patientsPrimary outcomeCare utilizationClinical trialsAcademic hospitalExploratory outcomesAUDProcess evaluation
2021
A pilot economic evaluation of computerized cognitive behavioral therapy for alcohol use disorder as an addition and alternative to traditional therapy
Kacmarek CN, Yates BT, Nich C, Kiluk BD. A pilot economic evaluation of computerized cognitive behavioral therapy for alcohol use disorder as an addition and alternative to traditional therapy. Alcohol Clinical And Experimental Research 2021, 45: 1109-1121. PMID: 33730384, PMCID: PMC8131237, DOI: 10.1111/acer.14601.Peer-Reviewed Original ResearchConceptsAlcohol use disorderIncremental cost-effective ratioCognitive behavioral therapyStandard outpatient treatmentPilot economic evaluationOutpatient treatmentTreatment costsUse disordersDrinking daysBehavioral therapyComputerized cognitive behavioral therapyEvidence-based treatmentsOutpatient treatment facilitiesTotal treatment costsCost of treatmentCost-effective ratioComputer-delivered interventionNet benefit analysisHealthcare utilizationCost-effective additionClinical trialsTreatment protocolCriminal justice involvementTraditional therapiesTreatment terminationCognitive-Behavioral Interventions Targeting Alcohol or Other Drug Use and Co-Occurring Mental Health Disorders: A Meta-Analysis
Mehta K, Hoadley A, Ray LA, Kiluk BD, Carroll KM, Magill M. Cognitive-Behavioral Interventions Targeting Alcohol or Other Drug Use and Co-Occurring Mental Health Disorders: A Meta-Analysis. Alcohol And Alcoholism 2021, 56: 535-544. PMID: 33778869, PMCID: PMC8406071, DOI: 10.1093/alcalc/agab016.Peer-Reviewed Original ResearchConceptsCognitive-behavioral interventionsMental health disordersCo-occurring mental health disordersHealth disordersDrug useEffect sizeDrug use disordersSignificant residual heterogeneityHigh-quality studiesMental health symptomsPost-traumatic stress disorderUnderstanding of treatmentMeta-regression modelsClinical trialsStudy qualityPromising effect sizesUse disordersStudy heterogeneityMHD diagnosisHealth symptomsMeta-AnalysisStress disorderAlcohol useTime pointsSmall effect sizes
2020
Evaluating a Longitudinal Mediation Model of Perceived Stress, Depressive Symptoms, and Substance Use Treatment Outcomes
Roos CR, Kiluk BD, McHugh RK, Carroll KM. Evaluating a Longitudinal Mediation Model of Perceived Stress, Depressive Symptoms, and Substance Use Treatment Outcomes. Psychology Of Addictive Behaviors 2020, 34: 660-668. PMID: 32297754, PMCID: PMC7483283, DOI: 10.1037/adb0000581.Peer-Reviewed Original ResearchConceptsIllicit opioid useOpioid useDepressive symptomsUse disordersSubstance use outcomesMethadone treatmentStandard methadone treatmentTrial of galantamineUse outcomesOpioid use disorderSubstance Use Treatment OutcomesSubstance use disordersCocaine use disorderCognitive behavioral therapyLongitudinal treatment studyTreatment outcomesPredictors of endPosttreatment outcomesSymptomsTreatment studiesSignificant total effectSubstance useBaselineOutcomesDisordersCombined Pharmacotherapy and Cognitive Behavioral Therapy for Adults With Alcohol or Substance Use Disorders
Ray LA, Meredith LR, Kiluk BD, Walthers J, Carroll KM, Magill M. Combined Pharmacotherapy and Cognitive Behavioral Therapy for Adults With Alcohol or Substance Use Disorders. JAMA Network Open 2020, 3: e208279. PMID: 32558914, PMCID: PMC7305524, DOI: 10.1001/jamanetworkopen.2020.8279.Peer-Reviewed Original ResearchConceptsSubstance use disordersAdult alcohol use disordersCognitive behavioral therapyUsual careRandomized clinical trialsUse disordersBehavioral therapySpecific therapyClinical trialsAddition of CBTSuperiority of CBTTreatment of SUDsUsual clinical managementForms of pharmacotherapyFirst-line interventionEvidence-based therapiesClinical trial samplesEvidence-based modalitiesAlcohol use disorderEnglish-language articlesPublic health concernFull-text articlesEffect sizeCochrane RegisterRandom effects estimatesThe search for mechanisms of cognitive behavioral therapy for alcohol or other drug use disorders: A systematic review
Magill M, Tonigan JS, Kiluk B, Ray L, Walthers J, Carroll K. The search for mechanisms of cognitive behavioral therapy for alcohol or other drug use disorders: A systematic review. Behaviour Research And Therapy 2020, 131: 103648. PMID: 32474226, PMCID: PMC7329023, DOI: 10.1016/j.brat.2020.103648.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyDrug use disordersUse disordersSystematic reviewBehavioral therapyRandomized clinical trialsStudy inclusion criteriaPatient behavior changeCBT-based treatmentClinical trialsInclusion criteriaStatistical mediatorMediator candidatesIntervention ingredientsProject MATCHCBT mechanismsTherapyBehavior change frameworkMediatorsBehavior changeDisordersAddiction researchReportReviewReview sampleShort- and long-term changes in substance-related coping as mediators of in-person and computerized CBT for alcohol and drug use disorders
Roos CR, Carroll KM, Nich C, Frankforter T, Kiluk BD. Short- and long-term changes in substance-related coping as mediators of in-person and computerized CBT for alcohol and drug use disorders. Drug And Alcohol Dependence 2020, 212: 108044. PMID: 32422538, PMCID: PMC7293942, DOI: 10.1016/j.drugalcdep.2020.108044.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyComputerized cognitive behavioral therapyPerson cognitive-behavioural therapySubstance use disordersMediation effectAlcohol use disorderComputer-delivered cognitive behavioural therapyUse disordersSame mediation effectSubstance-related copingCoping Strategies ScaleSignificant mediation effectMechanisms of changeMediational modelCoping skillsStrategies ScaleCBT4CBTStatistical mediatorCopingDrug use disordersSubstance useHeavy drinkingDisordersLong-term changesLong-term increaseThe state of clinical outcome assessments for cannabis use disorder clinical trials: A review and research agenda
Loflin MJE, Kiluk BD, Huestis MA, Aklin WM, Budney AJ, Carroll KM, D'Souza DC, Dworkin RH, Gray KM, Hasin DS, Lee DC, Le Foll B, Levin FR, Lile JA, Mason BJ, McRae-Clark AL, Montoya I, Peters EN, Ramey T, Turk DC, Vandrey R, Weiss RD, Strain EC. The state of clinical outcome assessments for cannabis use disorder clinical trials: A review and research agenda. Drug And Alcohol Dependence 2020, 212: 107993. PMID: 32360455, PMCID: PMC7293929, DOI: 10.1016/j.drugalcdep.2020.107993.Peer-Reviewed Original ResearchConceptsClinical outcome assessmentCannabis use disorderClinical trialsOutcome assessmentForms of cannabisCannabis-related harmsCannabis reductionPrimary outcomeFunctional outcomeInterpretation of outcomesClinical endpointsNew pharmacotherapiesPsychomotor impairmentOutcome measuresSelf-report assessmentsDiagnostic criteriaUse disordersOptimal durationCannabis useStudy designBiologic assaysTrialsOptimal outcomesLack of consensusCannabis
2019
Changes in DSM criteria following a culturally-adapted computerized CBT for Spanish-speaking individuals with substance use disorders
Silva MA, Jaramillo Y, Paris M, Añez-Nava L, Frankforter TL, Kiluk BD. Changes in DSM criteria following a culturally-adapted computerized CBT for Spanish-speaking individuals with substance use disorders. Journal Of Substance Use And Addiction Treatment 2019, 110: 42-48. PMID: 31952627, PMCID: PMC6981257, DOI: 10.1016/j.jsat.2019.12.006.Peer-Reviewed Original ResearchConceptsSubstance use disordersAddiction Severity IndexUse disordersDSM criteriaStructured Clinical InterviewDSM-IV substance dependenceMeaningful outcomesDiagnostic statusTimeline followback methodStatistical Manual criteriaCognitive behavioral therapy programBehavioral therapy programSubstance use outcomesProblem severityDSM-IV dependence criteriaPrimary outcomeUrine toxicologyLower problem severityClinical trialsTreatment periodMain trialOutpatient counselingClinical InterviewSecondary analysisDSM-IVA Meta-Analysis of Cognitive-Behavioral Therapy for Alcohol or Other Drug Use Disorders: Treatment Efficacy by Contrast Condition
Magill M, Ray L, Kiluk B, Hoadley A, Bernstein M, Tonigan JS, Carroll K. A Meta-Analysis of Cognitive-Behavioral Therapy for Alcohol or Other Drug Use Disorders: Treatment Efficacy by Contrast Condition. Journal Of Consulting And Clinical Psychology 2019, 87: 1093-1105. PMID: 31599606, PMCID: PMC6856400, DOI: 10.1037/ccp0000447.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyDrug use disordersUse disordersEffect sizeConsumption frequencyTime pointsEvidence-based therapiesPooled effect sizeMinimal treatmentEstimates of efficacyTest of heterogeneityCBT effectsNonspecific therapySpecific therapySuperior efficacyStudy-level moderatorsModerate heterogeneityTreatment efficacySignificant effect sizeMultivariate analysisMeta-AnalysisTherapyPublication biasStudy aimNonspecific controlAnhedonia as a Key Clinical Feature in the Maintenance and Treatment of Opioid Use Disorder
Kiluk BD, Yip SW, DeVito EE, Carroll KM, Sofuoglu M. Anhedonia as a Key Clinical Feature in the Maintenance and Treatment of Opioid Use Disorder. Clinical Psychological Science 2019, 7: 1190-1206. PMID: 32042509, PMCID: PMC7009780, DOI: 10.1177/2167702619855659.Peer-Reviewed Original ResearchOpioid use disorderClinical featuresUse disordersHigher anhedonia scoresKey clinical featuresRate of participantsAnhedonia scoresOpioid-dependent sampleOpioid cravingOpioid useTreatment adherenceHealthy controlsSignificant anhedoniaPharmacological interventionsAssessment of anhedoniaMajority of studiesPotential targetAnhedoniaTreatmentTime courseDisordersSignificant knowledge gapsScoresPotential implicationsCritical needSociodemographic and clinical outcome differences among individuals seeking treatment for cocaine use disorders. The intersection of gender and race
Miguel AQC, Jordan A, Kiluk BD, Nich C, Babuscio TA, Mari JJ, Carroll KM. Sociodemographic and clinical outcome differences among individuals seeking treatment for cocaine use disorders. The intersection of gender and race. Journal Of Substance Use And Addiction Treatment 2019, 106: 65-72. PMID: 31540613, PMCID: PMC6756185, DOI: 10.1016/j.jsat.2019.08.014.Peer-Reviewed Original ResearchConceptsCocaine use disorderTreatment trialsTreatment outcomesUse disordersWhite womenTreatment outcome indicatorsPoor overall outcomeClinical outcome differencesRandomized clinical trialsFocused treatment approachMore effective treatmentsDifferent psychosocial issuesSubstance use problemsSubgroup of individualsBaseline characteristicsPoor outcomePsychiatric comorbidityClinical trialsHigh prevalenceSociodemographic statusEffective treatmentOutcome differencesTreatment approachesPsychosocial issuesCocaine useComputerized Cognitive Behavioral Therapy for Substance Use Disorders: A Summary of the Evidence and Potential Mechanisms of Behavior Change
Kiluk BD. Computerized Cognitive Behavioral Therapy for Substance Use Disorders: A Summary of the Evidence and Potential Mechanisms of Behavior Change. Perspectives On Behavior Science 2019, 42: 465-478. PMID: 31976445, PMCID: PMC6768920, DOI: 10.1007/s40614-019-00205-2.Peer-Reviewed Original ResearchCognitive behavioral therapySubstance use disordersTraditional cognitive behavioral therapyComputerized cognitive behavioral therapyBehavior changeSubstance useBehavioral coping skillsComputer-delivered interventionComputerized CBT programUse disordersMinimal clinical monitoringCBT programCoping skillsBehavioral therapyCBT mechanismsRates of alcoholConsiderable empirical evidenceBehavioral skillsBehavioral interventionsTheory-driven assumptionsDifferent treatment settingsNew skillsStrong supportEvaluation of individualsTreatment terminationShort and long-term improvements in psychiatric symptomatology to validate clinically meaningful treatment outcomes for cocaine use disorders
Miguel AQC, Kiluk BD, Babuscio TA, Nich C, Mari JJ, Carroll KM. Short and long-term improvements in psychiatric symptomatology to validate clinically meaningful treatment outcomes for cocaine use disorders. Drug And Alcohol Dependence 2019, 198: 126-132. PMID: 30921648, PMCID: PMC6487863, DOI: 10.1016/j.drugalcdep.2019.01.046.Peer-Reviewed Original ResearchConceptsCocaine use disorderBrief Symptom InventoryCocaine use outcomesPsychiatric symptomatologyUse outcomesUse disordersPositive Symptom TotalDrug use outcomesMeaningful treatment outcomesInterpersonal sensitivityUse outcome measuresParanoid ideationSymptom TotalLong-term functional improvementSymptom InventoryLong-term associationPsychoticism dimensionOutcome effectsComposite scoreOutcome measuresSymptomatologyNegative urinalysis resultsGlobal indexComplete abstinenceLong-term improvement
2018
Accounting for the uncounted: Physical and affective distress in individuals dropping out of oral naltrexone treatment for opioid use disorder
Carroll KM, Nich C, Frankforter TL, Yip SW, Kiluk BD, DeVito EE, Sofuoglu M. Accounting for the uncounted: Physical and affective distress in individuals dropping out of oral naltrexone treatment for opioid use disorder. Drug And Alcohol Dependence 2018, 192: 264-270. PMID: 30300800, PMCID: PMC6203294, DOI: 10.1016/j.drugalcdep.2018.08.019.Peer-Reviewed Original ResearchConceptsOpioid use disorderOral naltrexoneUse disordersAffective symptomsVoucher-based contingency managementDysphoric symptomsAffective distressOral naltrexone treatmentMultiple baseline characteristicsBaseline characteristicsNaltrexone treatmentHigh riskNaltrexoneSomatic symptomsSymptomsContingency managementTreatmentHigh rateDistressSubstantial evidenceTrialsTheoretical benefitsDisordersAffective discomfortParticipantsCulturally Adapted, Web-Based Cognitive Behavioral Therapy for Spanish-Speaking Individuals With Substance Use Disorders: A Randomized Clinical Trial.
Paris M, Silva M, Añez-Nava L, Jaramillo Y, Kiluk BD, Gordon MA, Nich C, Frankforter T, Devore K, Ball SA, Carroll KM. Culturally Adapted, Web-Based Cognitive Behavioral Therapy for Spanish-Speaking Individuals With Substance Use Disorders: A Randomized Clinical Trial. American Journal Of Public Health 2018, 108: 1535-1542. PMID: 30252519, PMCID: PMC6187780, DOI: 10.2105/ajph.2018.304571.Peer-Reviewed Original ResearchConceptsSubstance use disordersCognitive-behavioral treatmentUse disordersSubstance use outcomesClinical trialsWeb-based cognitive behavioral therapyCurrent substance use disorderUse outcomesRandomized clinical trialsStandard outpatient treatmentEvidence-based treatmentsCognitive behavioral therapyPrimary outcomeStandard treatmentOutpatient treatmentStandard outpatientTreatment completionHealth disparitiesBehavioral therapyBehavioral treatmentAddiction treatmentTreatment-seeking individualsGreater reductionTreatmentDisorders