2024
National Estimates of Short- and Longer-Term Hospital Readmissions After Major Surgery Among Community-Living Older Adults
Wang Y, Leo-Summers L, Vander Wyk B, Davis-Plourde K, Gill T, Becher R. National Estimates of Short- and Longer-Term Hospital Readmissions After Major Surgery Among Community-Living Older Adults. JAMA Network Open 2024, 7: e240028. PMID: 38416499, PMCID: PMC10902728, DOI: 10.1001/jamanetworkopen.2024.0028.Peer-Reviewed Original ResearchConceptsCenters for Medicare & Medicaid ServicesFee-for-serviceMedicare Advantage beneficiariesHospital readmissionUS residentsNational Health and Aging Trends Study dataCommunity-living older adultsProspective longitudinal cohort studyCommunity-living participantsRate of hospital readmissionLikelihood of hospital readmissionPopulation-based estimatesNationally representative estimatesSex-adjusted modelsCommunity-livingData linkageGeriatric conditionsMedicaid ServicesOlder personsOlder adultsMain OutcomesNational estimatesRepresentative estimatesData analysisCohort study
2022
Population-Based Estimates of 1-Year Mortality After Major Surgery Among Community-Living Older US Adults
Gill TM, Vander Wyk B, Leo-Summers L, Murphy TE, Becher RD. Population-Based Estimates of 1-Year Mortality After Major Surgery Among Community-Living Older US Adults. JAMA Surgery 2022, 157: e225155. PMID: 36260323, PMCID: PMC9582971, DOI: 10.1001/jamasurg.2022.5155.Peer-Reviewed Original ResearchConceptsPopulation-based estimatesMajor surgeryMean survival timeOlder US adultsProbable dementiaUS adultsSurvival timeSex-adjusted hazard ratioProspective longitudinal cohort studyCommunity-living older adultsLongitudinal cohort studyPotential prognostic valueService Medicare beneficiariesNon-Hispanic blacksNon-Hispanic whitesAging Trends StudyGeriatric characteristicsCohort studyGeriatric surgeryHazard ratioNonelective surgeryElective surgeryGeriatric conditionsPrognostic valueMean ageDevelopment and validation of a prediction model for persistent functional impairment among older ICU survivors
Ferrante LE, Murphy TE, Leo‐Summers L, O'Leary JR, Vander Wyk B, Pisani MA, Gill TM. Development and validation of a prediction model for persistent functional impairment among older ICU survivors. Journal Of The American Geriatrics Society 2022, 71: 188-197. PMID: 36196998, PMCID: PMC9870848, DOI: 10.1111/jgs.18075.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBayes TheoremCritical IllnessFemaleHospitalizationHumansIntensive Care UnitsMalePatient DischargeSurvivorsConceptsPersistent functional impairmentICU hospitalizationFunctional impairmentValidation cohortICU admissionDevelopment cohortOlder Intensive Care Unit SurvivorsIntensive care unit survivorsOlder adultsOlder ICU survivorsMonths of dischargeHigh-risk survivorsCommunity-living participantsGood calibrationHospital lengthICU survivorsCritical illnessMedian agePrior hospitalizationFunctional recoveryNational HealthProbable dementiaHospitalizationHigh riskDepressive symptoms
2021
The Incidence and Cumulative Risk of Major Surgery in Older Persons in the United States
Becher RD, Vander Wyk B, Leo-Summers L, Desai MM, Gill TM. The Incidence and Cumulative Risk of Major Surgery in Older Persons in the United States. Annals Of Surgery 2021, 277: 87-92. PMID: 34261884, PMCID: PMC8758792, DOI: 10.1097/sla.0000000000005077.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overDementiaHumansIncidenceLongitudinal StudiesMedicareProspective StudiesUnited StatesConceptsMajor surgeryOlder personsCumulative riskNational HealthCommunity-living older personsHigh-quality surgical careNon-frail groupPopulation-based incidenceService Medicare beneficiariesMedicaid Services dataCumulative risk estimatesProspective longitudinal studyUnited States agesAging Trends StudyGeriatric characteristicsRepresentative incidenceFrail groupAdjusted incidenceGeriatric populationProbable dementiaSurgical carePersons 85Medicare beneficiariesSurgeryVulnerable subgroupsComparison of [11C]UCB-J and [18F]FDG PET in Alzheimer’s disease: A tracer kinetic modeling study
Chen MK, Mecca AP, Naganawa M, Gallezot JD, Toyonaga T, Mondal J, Finnema SJ, Lin SF, O’Dell R, McDonald JW, Michalak HR, Vander Wyk B, Nabulsi NB, Huang Y, Arnsten AF, van Dyck CH, Carson RE. Comparison of [11C]UCB-J and [18F]FDG PET in Alzheimer’s disease: A tracer kinetic modeling study. Cerebrovascular And Brain Metabolism Reviews 2021, 41: 2395-2409. PMID: 33757318, PMCID: PMC8393289, DOI: 10.1177/0271678x211004312.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAlzheimer DiseaseFemaleFluorodeoxyglucose F18HumansMaleMiddle AgedPositron-Emission TomographyConceptsSynaptic densityMedial temporal regionsAlzheimer's diseaseNeocortical regionsTemporal regionsRelative outcome measuresMedial temporal lobeVivo PET imagingJ bindingOutcome measuresTemporal lobeMagnitude of reductionCN participantsBrain regionsAD participantsDiseasePET imagingConcordant reductionNormal participantsSynaptic vesiclesPerfusionMetabolismSuitable markerParticipantsSimilar pattern
2020
Individual Heterogeneity in the Probability of Hospitalization, Skilled Nursing Facility Admission, and Mortality
McAvay GJ, Vander Wyk B, Allore H. Individual Heterogeneity in the Probability of Hospitalization, Skilled Nursing Facility Admission, and Mortality. The Journals Of Gerontology Series A 2020, 76: 1668-1677. PMID: 33320184, PMCID: PMC8361334, DOI: 10.1093/gerona/glaa314.Peer-Reviewed Original ResearchConceptsSkilled nursing facility admissionsNursing facility admissionsChronic kidney diseaseHeart failureFacility admissionKidney diseaseChronic conditionsChronic obstructive pulmonary diseaseObstructive pulmonary diseaseIschemic heart diseaseHealth care utilizationProbability of hospitalizationPulmonary diseaseCare utilizationMortality outcomesPoor outcomeHeart diseaseNational HealthOdds ratioDisease combinationsLongitudinal cohortSociodemographic factorsMedicaid ServicesDiseaseAging StudyIn vivo measurement of widespread synaptic loss in Alzheimer's disease with SV2A PET
Mecca AP, Chen M, O'Dell RS, Naganawa M, Toyonaga T, Godek TA, Harris JE, Bartlett HH, Zhao W, Nabulsi NB, Vander Wyk B, Varma P, Arnsten AFT, Huang Y, Carson RE, van Dyck C. In vivo measurement of widespread synaptic loss in Alzheimer's disease with SV2A PET. Alzheimer's & Dementia 2020, 16: 974-982. PMID: 32400950, PMCID: PMC7383876, DOI: 10.1002/alz.12097.Peer-Reviewed Original ResearchConceptsWidespread synaptic lossEarly Alzheimer's diseaseSynaptic lossAlzheimer's diseaseSynaptic vesicle glycoprotein 2AGray matter volumeMajor structural correlatePositron emission tomography (PET) imagingEmission Tomography ImagingDistribution volume ratioCerebellar reference regionNeocortical brain regionsSynaptic densityAD progressionConsistent pathologyPotential therapyMatter volumePromising biomarkerCognitive impairmentCN participantsBrain regionsDiseaseTomography imagingNormal participantsStructural correlates
2019
Sociodemographic Factors and Characteristics of Caregivers as Determinants of Skilled Nursing Facility Admissions When Modeled Jointly With Functional Limitations
Jørgensen TSH, Allore H, MacNeil Vroomen JL, Wyk BV, Agogo GO. Sociodemographic Factors and Characteristics of Caregivers as Determinants of Skilled Nursing Facility Admissions When Modeled Jointly With Functional Limitations. Journal Of The American Medical Directors Association 2019, 20: 1599-1604.e4. PMID: 30902676, PMCID: PMC7444598, DOI: 10.1016/j.jamda.2019.01.154.Peer-Reviewed Original ResearchConceptsSkilled nursing facility admissionsNursing facility admissionsSNF admissionCharacteristics of caregiversFunctional limitationsSociodemographic factorsCaregiver characteristicsPartner caregiversFacility admissionHigh-risk populationImpact of caregiversNon-Hispanic whitesAging Trends StudyRace/ethnicityNational HealthStudy populationAdmissionLongitudinal changesMedicaid ServicesOlder adultsFuture interventionsEffect estimatesCaregiversLower hazardOlder Americans