Effect of retinol in preventing squamous cell skin cancer in moderate-risk subjects: a randomized, double-blind, controlled trial. Southwest Skin Cancer Prevention Study Group.
Moon T, Levine N, Cartmel B, Bangert J, Rodney S, Dong Q, Peng Y, Alberts D. Effect of retinol in preventing squamous cell skin cancer in moderate-risk subjects: a randomized, double-blind, controlled trial. Southwest Skin Cancer Prevention Study Group. Cancer Epidemiology Biomarkers & Prevention 1997, 6: 949-56. PMID: 9367069.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaNew squamous-cell carcinomasModerate-risk subjectsSkin cancerHazard ratioNew nonmelanoma skin cancersSquamous cell skin cancerIU of retinolNew skin cancersPlacebo-supplemented subjectsPrimary end pointNonmelanoma skin cancerFree-living subjectsEffect of retinolMedian followOral retinolBasal cell carcinoma skin cancersActinic keratosesRetinol supplementationCell carcinomaDaily supplementationAdverse symptomsEnd pointCancerNew BCCRetinoids in prevention of skin cancer
Moon T, Levine N, Cartmel B, Bangert J. Retinoids in prevention of skin cancer. Cancer Letters 1997, 114: 203-205. PMID: 9103292, DOI: 10.1016/s0304-3835(97)04663-6.Peer-Reviewed Original ResearchConceptsBasal cell skin cancerModerate-risk subjectsPrior skin cancersHigh-risk subjectsRisk subjectsSkin cancerB trialSquamous cell skin cancerSquamous cell cancerEffects of retinoidsActinic keratosesCell cancerClinical trialsIntervention durationCancerTrialsRetinolRetinoidsPlaceboIncidencePreventionSubjectsSignificant benefitsIsotretinoinKeratoses