2016
Efficacy and Safety of the Collagenase of the Bacterium Clostridium Histolyticum for the Treatment of Capsular Contracture after Silicone Implants: Ex-Vivo Study on Human Tissue
Fischer S, Hirche C, Diehm Y, Nuutila K, Kiefer J, Gazyakan E, Bueno E, Kremer T, Kneser U, Pomahac B. Efficacy and Safety of the Collagenase of the Bacterium Clostridium Histolyticum for the Treatment of Capsular Contracture after Silicone Implants: Ex-Vivo Study on Human Tissue. PLOS ONE 2016, 11: e0156428. PMID: 27232716, PMCID: PMC4883774, DOI: 10.1371/journal.pone.0156428.Peer-Reviewed Original ResearchMeSH KeywordsBreast ImplantsCollagenDose-Response Relationship, DrugFemaleHumansImplant Capsular ContractureMicrobial CollagenaseSilicone GelsSkinConceptsFull-thickness skin graftThickness skin graftBacterium Clostridium histolyticumCapsular contractureSkin graftsBreast sitesSilicone implantsReasonable treatment optionClostridium histolyticumFibrotic capsuleCollagen subtypesEx vivo studyCollagenase doseEx-vivo settingTreatment optionsContracture tissueAcellular tissue matrixOutcome measuresHistological assessmentSubtype 4Capsule tissueClinical utilizationDifferent dosesClinical realityType 4
1998
Dermatan Sulfate Released after Injury Is a Potent Promoter of Fibroblast Growth Factor-2 Function*
Penc S, Pomahac B, Winkler T, Dorschner R, Eriksson E, Herndon M, Gallo R. Dermatan Sulfate Released after Injury Is a Potent Promoter of Fibroblast Growth Factor-2 Function*. Journal Of Biological Chemistry 1998, 273: 28116-28121. PMID: 9774430, DOI: 10.1074/jbc.273.43.28116.Peer-Reviewed Original ResearchMeSH KeywordsBody FluidsCell DivisionDermatan SulfateDose-Response Relationship, DrugFemaleFibroblast Growth Factor 2HumansMastectomyNeckWound HealingWounds, PenetratingConceptsWound fluidDermatan sulfateFactor 2 activityFibroblast growth factor-2Growth factor 2Factor 2 functionHuman wound fluidPotent mediatorSulfated glycosaminoglycan concentrationsSyndecan-1Fibroblast growth factor‐2 activityWound repairWound healingCell proliferationFGF-2Glycosaminoglycan concentrationSoluble proteoglycanFactor 2Immunoblot analysisVivo sourceHeparan sulfatePotent promoterFirst evidenceSyndecan-4Proteoglycans