2022
T cell-attracting CCL18 chemokine is a dominant rejection signal during limb transplantation
Borges T, Abarzua P, Gassen R, Kollar B, Lima-Filho M, Aoyama B, Gluhova D, Clark R, Islam S, Pomahac B, Murphy G, Lian C, Talbot S, Riella L. T cell-attracting CCL18 chemokine is a dominant rejection signal during limb transplantation. Cell Reports Medicine 2022, 3: 100559. PMID: 35492875, PMCID: PMC9040185, DOI: 10.1016/j.xcrm.2022.100559.Peer-Reviewed Original ResearchConceptsLimb transplantationTransplant recipientsSkin antigen-presenting cellsSolid organ transplant recipientsAccelerated graft rejectionOrgan transplant recipientsSkin transplantation modelAntigen-presenting cellsLife-changing procedureImmunosuppressive approachesTh17 cellsGraft rejectionGreater immunogenicityCell infiltrationSkin biopsiesTransplantation modelSkin xenograftsChemokine CCL18Immune moleculesTransplantationCCL18RecipientsMolecular characterizationChemokinesCCR8 receptor
2019
Multidisciplinary Treatment to Restore Vision in Ocular Burns
Christensen J, Shanbhag S, Shih G, Goverman J, Pomahac B, Chodosh J, Ehrlichman R. Multidisciplinary Treatment to Restore Vision in Ocular Burns. Journal Of Burn Care & Research 2019, 41: 859-865. PMID: 31808803, DOI: 10.1093/jbcr/irz201.Peer-Reviewed Original ResearchConceptsSplit-thickness skin graftFull-thickness skin graftKeratoprosthesis placementSkin graftsCorneal blindnessLight perceptionBilateral corneal blindnessGood visual prognosisConsecutive burn patientsLoss of visionMucous membrane graftPeriorbital soft tissueVisual prognosisChart reviewCorneal scarringMultidisciplinary treatmentPostoperative visionInitial treatmentBurn patientsCorneal injuryCicatricial ectropionOcular burnsTear productionMembrane graftGlobe protection
2016
Extra-large negative pressure wound therapy dressings for burns – Initial experience with technique, fluid management, and outcomes
Fischer S, Wall J, Pomahac B, Riviello R, Halvorson E. Extra-large negative pressure wound therapy dressings for burns – Initial experience with technique, fluid management, and outcomes. Burns 2016, 42: 457-465. PMID: 26774601, DOI: 10.1016/j.burns.2015.08.034.Peer-Reviewed Original ResearchConceptsTotal body surface areaLength of stayWound infectionNPWT dressingsNegative pressure wound therapy dressingsExcision/graftingAcute kidney injuryBody surface areaRisk of infectionLarge burn woundsAverage graftKidney injuryFluid resuscitationIll patientsEarly outcomesImproved outcomesFluid managementWound careExtensive burnsDay 1PatientsWound sizeNPWTPatient careGraft
2014
Acute rejection in vascularized composite allotransplantation
Fischer S, Lian C, Kueckelhaus M, Strom T, Edelman E, Clark R, Murphy G, Chandraker A, Riella L, Tullius S, Pomahac B. Acute rejection in vascularized composite allotransplantation. Current Opinion In Organ Transplantation 2014, 19: 531-544. PMID: 25333831, DOI: 10.1097/mot.0000000000000140.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAnimalsGraft RejectionHumansImmune ToleranceSkinSkin TransplantationVascularized Composite AllotransplantationConceptsAcute rejection episodesAcute rejectionRejection episodesComposite allotransplantationDepth histological analysisHigh-dose steroidsLong-term safetyField of transplantationBetter diagnostic toolsFace transplant recipientsMaintenance immunosuppressionSteroid withdrawalTransplant recipientsCommon complicationImmunologic eventsAppropriate therapyPatient numbersTimely institutionRestorative surgeryDose reductionEarly diagnosisMost episodesNovel biomarkersHigh immunogenicityPatient careFortschritte in der Gesichtstransplantation
Kueckelhaus M, Lehnhardt M, Fischer S, Eriksson E, Pomahac B, Hirsch T. Fortschritte in der Gesichtstransplantation. Handchirurgie · Mikrochirurgie · Plastische Chirurgie 2014, 46: 206-213. PMID: 25162238, DOI: 10.1055/s-0034-1385850.Peer-Reviewed Original ResearchMeSH KeywordsEstheticsFacial TransplantationForecastingGermanyHumansImmunosuppression TherapyMicrosurgeryOrgan PreservationPatient SelectionSkin TransplantationConceptsVascularised composite allotransplantationFace transplantationLife-threatening side effectsSolid organ transplantationDifferent transplant centersImmunosuppressive regimensMaintenance immunosuppressionVCA proceduresImmunosuppressive strategiesTransplant centersPatients' qualityLifelong immunosuppressionOrgan preservationSurgical techniqueOrgan transplantationComposite allograftsComposite allotransplantationSide effectsTransplantationFunctional reintegrationImmunosuppressionAnatomic structuresImmunogenic partFirst caseDifferent protocols
2013
Lessons Learned from Simultaneous Face and Bilateral Hand Allotransplantation
Carty M, Hivelin M, Dumontier C, Talbot S, Benjoar M, Pribaz J, Lantieri L, Pomahac B. Lessons Learned from Simultaneous Face and Bilateral Hand Allotransplantation. Plastic & Reconstructive Surgery 2013, 132: 423-432. PMID: 23584623, DOI: 10.1097/prs.0b013e318295883d.Peer-Reviewed Original Research
2012
Predictors for Major Wound Complications Following Preoperative Radiotherapy and Surgery for Soft-Tissue Sarcoma of the Extremities and Trunk: Importance of Tumor Proximity to Skin Surface
Baldini E, Lapidus M, Wang Q, Manola J, Orgill D, Pomahac B, Marcus K, Bertagnolli M, Devlin P, George S, Abraham J, Ferrone M, Ready J, Raut C. Predictors for Major Wound Complications Following Preoperative Radiotherapy and Surgery for Soft-Tissue Sarcoma of the Extremities and Trunk: Importance of Tumor Proximity to Skin Surface. Annals Of Surgical Oncology 2012, 20: 1494-1499. PMID: 23242820, DOI: 10.1245/s10434-012-2797-1.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overDiabetes ComplicationsDisease-Free SurvivalFemaleHumansLower ExtremityMaleMiddle AgedNeoadjuvant TherapyNeoplasm Recurrence, LocalPostoperative ComplicationsRadiotherapy, AdjuvantSarcomaSkinSkin TransplantationSoft Tissue NeoplasmsSurgical FlapsTorsoUpper ExtremityWound HealingYoung AdultConceptsMajor wound complicationsSoft tissue sarcomasSplit-thickness skin graftPreoperative radiotherapyWound complicationsPostoperative radiotherapyMultivariable analysisTumor proximityExact testResultsMedian tumor sizeSimilar local controlOverall survival rateLong-term fibrosisSignificant predictorsFisher's exact testHigh rateNonoperative managementIndependent predictorsRadical resectionTumor sizeSkin surfaceUnivariate analysisSkin graftsComplicationsLocal controlEpidermal Regeneration by Micrograft Transplantation with Immediate 100-Fold Expansion
Hackl F, Bergmann J, Granter S, Koyama T, Kiwanuka E, Zuhaili B, Pomahac B, Caterson E, Junker J, Eriksson E. Epidermal Regeneration by Micrograft Transplantation with Immediate 100-Fold Expansion. Plastic & Reconstructive Surgery 2012, 129: 443e-452e. PMID: 22373992, DOI: 10.1097/prs.0b013e318241289c.Peer-Reviewed Original ResearchConceptsSplit-thickness skin graftSkin graftsDermal sideEarly clinical resultsCorresponding time pointsFull-thickness woundsMicrograft transplantationDiabetic pigsClinical resultsMajor burnsCurrent treatmentSkin micrograftsComplete epithelializationDiabetic woundsWound chambersPercent reepithelializationGraftChronic woundsHealthy pigsTime pointsWound repairWoundsTransplantationMicrograftsEpidermal regeneration
2010
Use of a Bilobed Gracilis Myocutaneous Flap in Perineal and Genital Reconstruction
Vyas R, Pomahac B. Use of a Bilobed Gracilis Myocutaneous Flap in Perineal and Genital Reconstruction. Annals Of Plastic Surgery 2010, 65: 225-227. PMID: 20606582, DOI: 10.1097/sap.0b013e3181c9c434.Peer-Reviewed Original ResearchMeshed Skin Grafts Placed Upside Down Can Take If Desiccation Is Prevented
Zuhaili B, Aflaki P, Koyama T, Fossum M, Reish R, Schmidt B, Pomahac B, Eriksson E. Meshed Skin Grafts Placed Upside Down Can Take If Desiccation Is Prevented. Plastic & Reconstructive Surgery 2010, 125: 855-865. PMID: 20195112, PMCID: PMC2848958, DOI: 10.1097/prs.0b013e3181ccdc42.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBasement MembraneDesiccationEpitheliumGraft SurvivalSkin TransplantationSwineTransplantation, AutologousWound HealingConceptsSkin graftsMeshed graftReepithelialization rateSplit-thickness skin graftMeshed skin graftAutologous split-thickness skin graftWound environmentFull-thickness woundsHistologic specimensAccelerated reepithelializationDay 4GraftHigh contraction rateWound contractionSheet graftsWound healingWoundsYorkshire pigsSignificant differencesSurvivalHealingRegular graftsReepithelializationContraction rateCurrent study
2009
The Skin Allograft Revisited: A Potentially Permanent Wound Coverage Option in the Critically Ill Patient
Pomahac B, Garcia J, Lazar A, Tilney N, Orgill D. The Skin Allograft Revisited: A Potentially Permanent Wound Coverage Option in the Critically Ill Patient. Plastic & Reconstructive Surgery 2009, 123: 1755-1758. PMID: 19483575, DOI: 10.1097/prs.0b013e3181a65b1b.Peer-Reviewed Original Research
2007
The Role of Free-Tissue Transfer for Head and Neck Burn Reconstruction
Parrett B, Pomahac B, Orgill D, Pribaz J. The Role of Free-Tissue Transfer for Head and Neck Burn Reconstruction. Plastic & Reconstructive Surgery 2007, 120: 1871-1878. PMID: 18090749, DOI: 10.1097/01.prs.0000287272.28417.14.Peer-Reviewed Original ResearchConceptsFree flapBurn reconstructionTissue transferMean patient ageMedian hospital stayPercent of flapsMajority of flapsDonor site complicationsFree flap transferFree tissue transferReconstruction of headHospital stayPatient ageMain indicationsMinimal morbidityNeck burnsNecrosis rateAnterolateral thighHypertrophic scarringSecondary reconstructionRadial forearmFlap transferInfection rateLocal flapsCervicofacial burns
2002
Autologous Skin Transplantation: Comparison of Minced Skin to Other Techniques
Svensjö T, Pomahac B, Yao F, Slama J, Wasif N, Eriksson E. Autologous Skin Transplantation: Comparison of Minced Skin to Other Techniques. Journal Of Surgical Research 2002, 103: 19-29. PMID: 11855913, DOI: 10.1006/jsre.2001.6331.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCells, CulturedEpitheliumFemaleKeratinocytesMinimally Invasive Surgical ProceduresSkin TransplantationSwineWound Healing
1998
Tissue Engineering of Skin
Pomahač B, Svensjö T, Yao F, Brown H, Eriksson E. Tissue Engineering of Skin. Journal Of Dental Research 1998, 9: 333-344. PMID: 9715370, DOI: 10.1177/10454411980090030601.Peer-Reviewed Original Research