2020
Local immunosuppression in vascularized composite allotransplantation (VCA): A systematic review
Safi AF, Kauke M, Nelms L, Palmer WJ, Tchiloemba B, Kollar B, Haug V, Pomahač B. Local immunosuppression in vascularized composite allotransplantation (VCA): A systematic review. Journal Of Plastic Reconstructive & Aesthetic Surgery 2020, 74: 327-335. PMID: 33229219, DOI: 10.1016/j.bjps.2020.10.003.Peer-Reviewed Original ResearchConceptsLocal immunosuppressionSystematic reviewAllograft survivalComposite allotransplantationAllograft survival dataCell-based therapy strategiesImproved allograft survivalMain immunosuppressive agentMeta-Analyses (PRISMA) guidelinesPreclinical animal studiesPreferred Reporting ItemsMalignant side effectsImmunosuppressive agentsPreclinical dataSignificant prolongationRat modelHuman trialsExclusion criteriaImmunosuppressionSide effectsAnimal studiesReporting ItemsPubMed databaseSystemic toxicityTherapy strategies
2019
Twenty-Four-Hour Ex Vivo Perfusion with Acellular Solution Enables Successful Replantation of Porcine Forelimbs.
Krezdorn N, Macleod F, Tasigiorgos S, Turk M D M, Wo L, Kiwanuka B A H, Lopdrup B I D R, Kollar B, Edelman E, Pomahac B. Twenty-Four-Hour Ex Vivo Perfusion with Acellular Solution Enables Successful Replantation of Porcine Forelimbs. Plastic & Reconstructive Surgery 2019, 144: 608e-618e. PMID: 31568296, DOI: 10.1097/prs.0000000000006084.Peer-Reviewed Original Research
2018
Reduced Hypoxia-Related Genes in Porcine Limbs in Ex Vivo Hypothermic Perfusion Versus Cold Storage
Krezdorn N, Sakthivel D, Turk M, Aycart M, Tasigiorgos S, Bueno E, Sinha I, Pomahac B. Reduced Hypoxia-Related Genes in Porcine Limbs in Ex Vivo Hypothermic Perfusion Versus Cold Storage. Journal Of Surgical Research 2018, 232: 137-145. PMID: 30463709, DOI: 10.1016/j.jss.2018.05.067.Peer-Reviewed Original ResearchConceptsStatic cold storagePerfusion groupIschemia-reperfusion injuryPCR gene arrayPorcine limbsMuscle fiber disruptionIschemic injuryPerfadex solutionPerfused limbMachine perfusionHypothermic perfusionHistological changesPreservation modalityMuscle biopsyLimb replantationPerfusionICE groupLess activationPorcine forelimbDownregulation of genesMolecular changesLimbFiber disruptionExpression levelsReplantation
2017
Acellular Hypothermic Extracorporeal Perfusion Extends Allowable Ischemia Time in a Porcine Whole Limb Replantation Model
Kueckelhaus M, Dermietzel A, Alhefzi M, Aycart M, Fischer S, Krezdorn N, Wo L, Maarouf O, Riella L, Abdi R, Bueno E, Pomahac B. Acellular Hypothermic Extracorporeal Perfusion Extends Allowable Ischemia Time in a Porcine Whole Limb Replantation Model. Plastic & Reconstructive Surgery 2017, 139: 922e-932e. PMID: 28350667, DOI: 10.1097/prs.0000000000003208.Peer-Reviewed Original Research
2016
A Mobile Extracorporeal Extremity Salvage System for Replantation and Transplantation
Kueckelhaus M, Fischer S, Sisk G, Kiwanuka H, Bueno E, Dermietzel A, Alhefzi M, Aycart M, Diehm Y, Pomahac B. A Mobile Extracorporeal Extremity Salvage System for Replantation and Transplantation. Annals Of Plastic Surgery 2016, 76: 355-360. PMID: 26808757, DOI: 10.1097/sap.0000000000000681.Peer-Reviewed Original ResearchConceptsMuscle damageLimb lossPerfusion deviceDeceased organ donorsIschemic muscle damageBilateral hind limbsPreferred treatmentBilateral limbsMuscle biopsyOrgan donorsTraumatic amputationHealthy limbPerfusion solutionReplantationArterial systemTransplantationHypoxic cellsPerfusate compositionHind limbPorcine limbsLimbSignificant differencesYorkshire pigsSalvage systemSimilar changes
2015
Surgical Anatomy of the Whole Facial Nerve for Enabling Craniofacial and Regenerative Medicine Translational Research in Swine
Aycart M, Alhefzi M, Bueno E, Pomahac B. Surgical Anatomy of the Whole Facial Nerve for Enabling Craniofacial and Regenerative Medicine Translational Research in Swine. Journal Of Reconstructive Microsurgery 2015, 31: 547-550. PMID: 26115545, DOI: 10.1055/s-0035-1555113.Peer-Reviewed Original Research
2012
Epidermal Regeneration by Micrograft Transplantation with Immediate 100-Fold Expansion
Hackl F, Bergmann J, Granter S, Koyama T, Kiwanuka E, Zuhaili B, Pomahac B, Caterson E, Junker J, Eriksson E. Epidermal Regeneration by Micrograft Transplantation with Immediate 100-Fold Expansion. Plastic & Reconstructive Surgery 2012, 129: 443e-452e. PMID: 22373992, DOI: 10.1097/prs.0b013e318241289c.Peer-Reviewed Original ResearchConceptsSplit-thickness skin graftSkin graftsDermal sideEarly clinical resultsCorresponding time pointsFull-thickness woundsMicrograft transplantationDiabetic pigsClinical resultsMajor burnsCurrent treatmentSkin micrograftsComplete epithelializationDiabetic woundsWound chambersPercent reepithelializationGraftChronic woundsHealthy pigsTime pointsWound repairWoundsTransplantationMicrograftsEpidermal regeneration
2010
Meshed Skin Grafts Placed Upside Down Can Take If Desiccation Is Prevented
Zuhaili B, Aflaki P, Koyama T, Fossum M, Reish R, Schmidt B, Pomahac B, Eriksson E. Meshed Skin Grafts Placed Upside Down Can Take If Desiccation Is Prevented. Plastic & Reconstructive Surgery 2010, 125: 855-865. PMID: 20195112, PMCID: PMC2848958, DOI: 10.1097/prs.0b013e3181ccdc42.Peer-Reviewed Original ResearchConceptsSkin graftsMeshed graftReepithelialization rateSplit-thickness skin graftMeshed skin graftAutologous split-thickness skin graftWound environmentFull-thickness woundsHistologic specimensAccelerated reepithelializationDay 4GraftHigh contraction rateWound contractionSheet graftsWound healingWoundsYorkshire pigsSignificant differencesSurvivalHealingRegular graftsReepithelializationContraction rateCurrent study
2009
Use of a non–cross-linked porcine dermal scaffold in abdominal wall reconstruction
Pomahac B, Aflaki P. Use of a non–cross-linked porcine dermal scaffold in abdominal wall reconstruction. The American Journal Of Surgery 2009, 199: 22-27. PMID: 19427629, DOI: 10.1016/j.amjsurg.2008.12.033.Peer-Reviewed Original ResearchMeSH KeywordsAbdominal WallAdultAgedAged, 80 and overAnimalsBiocompatible MaterialsCohort StudiesCollagenFemaleFollow-Up StudiesHernia, AbdominalHernia, VentralHumansMaleMiddle AgedPlastic Surgery ProceduresRetrospective StudiesSeverity of Illness IndexSurgical Wound DehiscenceSuture TechniquesSwineTensile StrengthTreatment OutcomeWound HealingYoung AdultConceptsAbdominal wall reconstructionSuperficial wound dehiscenceAbdominal wallComplex abdominal wallWall reconstructionWound dehiscencePorcine dermalProsthetic meshRetrospective chart reviewIntra-abdominal catastropheSurgical site infectionLarge incisional herniasGiant ventral herniasComplicated abdominal wallMean followMultiorgan failureAbdominal traumaEmergency surgeryOpen abdomenChart reviewSite infectionAbdominal closureFistula formationWound infectionIncisional hernia
2007
Safety Evaluation of Topically Applied Amitriptyline in Porcine Full-Thickness Wounds
Pomahac B, Zuhaili B, Kudsi Y, Bleiziffer O, Velander P, Eriksson E, Gerner P. Safety Evaluation of Topically Applied Amitriptyline in Porcine Full-Thickness Wounds. Regional Anesthesia & Pain Medicine 2007, 32: 377-381. PMID: 17961834, DOI: 10.1016/j.rapm.2007.06.003.Peer-Reviewed Original ResearchConceptsFull-thickness woundsPorcine full-thickness woundsSerum levelsWound chambersTopical applicationWound contractionEffects of amitriptylineManagement of painDaily topical applicationHigher serum levelsExcised burn woundsFull-thickness skin biopsiesOvert toxic effectsLevels of amitriptylineTricyclic antidepressant amitriptylineNeuropathic painPain clinicHistopathological findingsNormal salineSkin biopsiesHistological assessmentAntidepressant amitriptylineDay 2Control groupAmitriptyline
2002
Cultured autologous fibroblasts augment epidermal repair1
Svensjo T, Yao F, Pomahac B, Winkler T, Eriksson E. Cultured autologous fibroblasts augment epidermal repair1. Transplantation 2002, 73: 1033-1041. PMID: 11965028, DOI: 10.1097/00007890-200204150-00004.Peer-Reviewed Original ResearchAutologous Skin Transplantation: Comparison of Minced Skin to Other Techniques
Svensjö T, Pomahac B, Yao F, Slama J, Wasif N, Eriksson E. Autologous Skin Transplantation: Comparison of Minced Skin to Other Techniques. Journal Of Surgical Research 2002, 103: 19-29. PMID: 11855913, DOI: 10.1006/jsre.2001.6331.Peer-Reviewed Original Research
2001
Autologous Keratinocyte Suspensions Accelerate Epidermal Wound Healing in Pigs
Svensjö T, Yao F, Pomahac B, Eriksson E. Autologous Keratinocyte Suspensions Accelerate Epidermal Wound Healing in Pigs. Journal Of Surgical Research 2001, 99: 211-221. PMID: 11469889, DOI: 10.1006/jsre.2001.6197.Peer-Reviewed Original Research
2000
Accelerated Healing of Full-Thickness Skin Wounds in a Wet Environment
Svensjö T, Pomahac B, Yao F, Slama J, Eriksson E. Accelerated Healing of Full-Thickness Skin Wounds in a Wet Environment. Plastic & Reconstructive Surgery 2000, 106: 602-612. PMID: 10987467, DOI: 10.1097/00006534-200009010-00012.Peer-Reviewed Original ResearchConceptsFull-thickness skin woundsSkin woundsAccelerated healingSaline-treated woundsGranulation tissue formationYoung Yorkshire pigsSecondary intentionTreatment modalitiesWound healing processSkin wound repairGranulation tissueWound healing modelWound contractionStandardized fashionPorcine wound healing modelFast contractionHealing processWound repairWoundsCell layerYorkshire pigsMoist woundSkin repairHealing modelHealing