2018
Reduced Hypoxia-Related Genes in Porcine Limbs in Ex Vivo Hypothermic Perfusion Versus Cold Storage
Krezdorn N, Sakthivel D, Turk M, Aycart M, Tasigiorgos S, Bueno E, Sinha I, Pomahac B. Reduced Hypoxia-Related Genes in Porcine Limbs in Ex Vivo Hypothermic Perfusion Versus Cold Storage. Journal Of Surgical Research 2018, 232: 137-145. PMID: 30463709, DOI: 10.1016/j.jss.2018.05.067.Peer-Reviewed Original ResearchConceptsStatic cold storagePerfusion groupIschemia-reperfusion injuryPCR gene arrayPorcine limbsMuscle fiber disruptionIschemic injuryPerfadex solutionPerfused limbMachine perfusionHypothermic perfusionHistological changesPreservation modalityMuscle biopsyLimb replantationPerfusionICE groupLess activationPorcine forelimbDownregulation of genesMolecular changesLimbFiber disruptionExpression levelsReplantation
2017
Tissue conservation for transplantation
Krezdorn N, Tasigiorgos S, Wo L, Turk M, Lopdrup R, Kiwanuka H, Win T, Bueno E, Pomahac B. Tissue conservation for transplantation. Innovative Surgical Sciences 2017, 2: 171-187. PMID: 31579751, PMCID: PMC6754021, DOI: 10.1515/iss-2017-0010.Peer-Reviewed Original ResearchOrgan preservationLong-term allograft functionPreservation of organsStatic cold storageAllograft functionSubsequent reperfusionIschemic preconditioningPathophysiological changesMechanical perfusionTransplantationTissue conservationCurrent literature pointsTherapeutic additivesGold standardPreservation protocolsOrgansCurrent bodyTissueReperfusionIschemiaInjuryPerfusion