2019
Blood proteome profiling using aptamer-based technology for rejection biomarker discovery in transplantation
Shubin A, Kollar B, Dillon S, Pomahac B, Libermann T, Riella L. Blood proteome profiling using aptamer-based technology for rejection biomarker discovery in transplantation. Scientific Data 2019, 6: 314. PMID: 31819064, PMCID: PMC6901551, DOI: 10.1038/s41597-019-0324-y.Peer-Reviewed Original ResearchConceptsDevastating facial injuriesSevere rejection episodesAcute transplant rejectionType of transplantationPeripheral blood serumSOMAscan proteomics platformSatisfactory treatment optionAcute rejectionRejection episodesTransplant statusTransplantation centersTransplant rejectionTreatment optionsBiomarker discoverySkin biopsiesClinical dataHigh riskFacial injuriesInvasive biomarkersTransplantationAptamer-based technologiesFace transplantationPatientsBlood serumSerum proteins
2018
Increased levels of circulating MMP3 correlate with severe rejection in face transplantation
Kollar B, Shubin A, Borges T, Tasigiorgos S, Win T, Lian C, Dillon S, Gu X, Wyrobnik I, Murphy G, Pomahac B, Libermann T, Riella L. Increased levels of circulating MMP3 correlate with severe rejection in face transplantation. Scientific Reports 2018, 8: 14915. PMID: 30297859, PMCID: PMC6175842, DOI: 10.1038/s41598-018-33272-7.Peer-Reviewed Original ResearchConceptsSevere rejectionFace transplantationLarge independent patient cohortsAcute rejection episodesAnti-rejection treatmentFirst postoperative yearLongitudinal serum samplesNon-invasive candidate biomarkersViable treatment optionSOMAscan proteomics platformIndependent patient cohortsFace transplant recipientsRejection episodesPostoperative yearTransplant recipientsDevastating injuriesMMP3 levelsTransplant rejectionHistological gradePatient cohortTreatment optionsSurrogate markerMMP3 proteinCandidate biomarkersTransplantation