2022
T cell-attracting CCL18 chemokine is a dominant rejection signal during limb transplantation
Borges T, Abarzua P, Gassen R, Kollar B, Lima-Filho M, Aoyama B, Gluhova D, Clark R, Islam S, Pomahac B, Murphy G, Lian C, Talbot S, Riella L. T cell-attracting CCL18 chemokine is a dominant rejection signal during limb transplantation. Cell Reports Medicine 2022, 3: 100559. PMID: 35492875, PMCID: PMC9040185, DOI: 10.1016/j.xcrm.2022.100559.Peer-Reviewed Original ResearchConceptsLimb transplantationTransplant recipientsSkin antigen-presenting cellsSolid organ transplant recipientsAccelerated graft rejectionOrgan transplant recipientsSkin transplantation modelAntigen-presenting cellsLife-changing procedureImmunosuppressive approachesTh17 cellsGraft rejectionGreater immunogenicityCell infiltrationSkin biopsiesTransplantation modelSkin xenograftsChemokine CCL18Immune moleculesTransplantationCCL18RecipientsMolecular characterizationChemokinesCCR8 receptor
2018
486 Molecular analysis differentiates inflammatory dermatoses from skin rejection in face transplant recipients
Win T, Dyring-Andersen B, Teague J, Riella L, Pomahac B, Clark R. 486 Molecular analysis differentiates inflammatory dermatoses from skin rejection in face transplant recipients. Journal Of Investigative Dermatology 2018, 138: s82. DOI: 10.1016/j.jid.2018.03.493.Peer-Reviewed Original Research
2016
The role of face transplantation in the self-inflicted gunshot wound
Kiwanuka H, Aycart M, Gitlin D, Devine E, Perry B, Win T, Bueno E, Alhefzi M, Krezdorn N, Pomahac B. The role of face transplantation in the self-inflicted gunshot wound. Journal Of Plastic Reconstructive & Aesthetic Surgery 2016, 69: 1636-1647. PMID: 27720683, DOI: 10.1016/j.bjps.2016.08.014.Peer-Reviewed Original ResearchMeSH KeywordsAdultBone TransplantationDecision Making, Computer-AssistedFacial InjuriesFacial TransplantationFemaleHumansMaleMass ScreeningMiddle AgedPatient SatisfactionPlastic Surgery ProceduresPsychological TechniquesRetrospective StudiesSelf-Injurious BehaviorSurgical FlapsTreatment OutcomeUnited StatesWounds, GunshotConceptsSelf-inflicted gunshot woundsFace transplantationGunshot woundsFT recipientsPsychosocial outcomesSubset of patientsPartial face transplantationFree tissue transferLoco-regional flapsSerial debridementConventional reconstructionWomen's HospitalMultidisciplinary evaluationRetrospective analysisAesthetic deficitsNormal restorationSoft tissue repairMental illnessTissue transferReconstructive surgeonPsychosocial componentsSuicidal behaviorScreening processMidfacial defectsRecipients
2015
Noninvasive Monitoring of Immune Rejection in Face Transplant Recipients
Kueckelhaus M, Imanzadeh A, Fischer S, Kumamaru K, Alhefzi M, Bueno E, Wake N, Gerhard-Herman M, Rybicki F, Pomahac B. Noninvasive Monitoring of Immune Rejection in Face Transplant Recipients. Plastic & Reconstructive Surgery 2015, 136: 1082-1089. PMID: 26505709, DOI: 10.1097/prs.0000000000001703.Peer-Reviewed Original ResearchConceptsFace transplant recipientsTransplant recipientsChronic rejectionCLINICAL QUESTION/LEVELAllograft biopsy specimensTotal vessel diameterSolid organ allograftsAllograft lossOrgan allograftsPostsurgical monitoringFlap arteryControl subjectsBiopsy specimensIntimal thicknessClinical signsRadial arteryThicker intimaUltrasound biomicroscopyFacial arteryMedia thicknessHistologic analysisImmune rejectionArteryRecipientsInterobserver correlationInitial Experience of Dual Maintenance Immunosuppression With Steroid Withdrawal in Vascular Composite Tissue Allotransplantation
Diaz-Siso J, Fischer S, Sisk G, Bueno E, Kueckelhaus M, Talbot S, Carty M, Treister N, Marty F, Milford E, Pomahac B, Tullius S. Initial Experience of Dual Maintenance Immunosuppression With Steroid Withdrawal in Vascular Composite Tissue Allotransplantation. American Journal Of Transplantation 2015, 15: 1421-1431. PMID: 25777324, DOI: 10.1111/ajt.13103.Peer-Reviewed Original ResearchConceptsAcute rejectionVCA recipientsMaintenance immunosuppressionSteroid-resistant acute rejectionLate acute rejectionSolid organ transplantationComposite tissue allotransplantationMaintenance steroidsTopical immunosuppressionCurrent immunosuppressionSteroid withdrawalBolus treatmentOrgan transplantationLow doseImmunosuppressionTissue allotransplantationInitial experienceFurther experienceSteroidsRecipientsTacrolimusPatientsTreatmentMonthsLow levels
2014
Functional Outcomes of Face Transplantation
Fischer S, Kueckelhaus M, Pauzenberger R, Bueno E, Pomahac B. Functional Outcomes of Face Transplantation. American Journal Of Transplantation 2014, 15: 220-233. PMID: 25359281, DOI: 10.1111/ajt.12956.Peer-Reviewed Original Research
2013
Current Principles of Facial Allotransplantation
Pomahac B, Bueno E, Sisk G, Pribaz J. Current Principles of Facial Allotransplantation. Plastic & Reconstructive Surgery 2013, 131: 1069-1076. PMID: 23629089, PMCID: PMC4374342, DOI: 10.1097/prs.0b013e3182865cd3.Peer-Reviewed Original ResearchConceptsTransplant recipientsSurgical principlesFace transplant recipientsFacial allotransplantationFull screening procedureReturn of motorFace transplant candidatesFundamental surgical principlesTransplant candidatesTransplantation teamWomen's HospitalSevere casesSensory functionPatientsUnique caseAllotransplantationClinical volumeFacial disfigurementRecipientsHospitalScreening procedureFacial restorationCurrent principlesBrigham
2012
Psychosocial Changes 6 Months after Face Transplantation
Chang G, Pomahac B. Psychosocial Changes 6 Months after Face Transplantation. Journal Of The Academy Of Consultation-Liaison Psychiatry 2012, 54: 367-371. PMID: 23194929, PMCID: PMC3593952, DOI: 10.1016/j.psym.2012.07.012.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalAdultFacial TransplantationFemaleFollow-Up StudiesHumansInterpersonal RelationsInterview, PsychologicalLinear ModelsMaleOutcome Assessment, Health CarePostoperative PeriodPsychiatric Status Rating ScalesQuality of LifeSelf ConceptSurveys and QuestionnairesTime FactorsConceptsMental healthComprehensive psychiatric assessmentChanges 6 monthsCommon clinical practiceFull facial transplantationNovel surgical procedureMOS SF-12Facial transplantationOverall mental healthTransplantation programPsychosocial statusSurgical proceduresEQ-5D.Life measuresPsychiatric assessmentClinical practiceTransplantationPsychosocial changesFace transplantationMonthsRecipientsSurgeryMeasures 3Assessment protocolSame period