2019
Face transplantation
Sinha I, Vyas R, Pomahac B. Face transplantation. 2019, 379-382. DOI: 10.1093/med/9780199699537.003.0045.Peer-Reviewed Original ResearchReturn of sensationSevere traumatic injuryComposite tissue allotransplantationComposite tissue transplantationFacial composite tissue allotransplantationTransplanted allograftPost transplantationLifelong immunosuppressionMotor functionTraumatic injuryTissue allotransplantationPsychiatric issuesPatientsTissue transplantationInfection riskTransplantationFace transplantationFacial formImmunosuppressionAllograftsAllotransplantationInjuryPossible rejectionMonths
2015
Reconstructive Management of Devastating Electrical Injuries to the Face
Janis J, Khansa I, Lehrman C, Orgill D, Pomahac B. Reconstructive Management of Devastating Electrical Injuries to the Face. Plastic & Reconstructive Surgery 2015, 136: 839-847. PMID: 26090762, DOI: 10.1097/prs.0000000000001619.Peer-Reviewed Original ResearchConceptsElectrical injuryFace transplantationCase seriesTrauma centerReconstructive challengeLevel 1 trauma centerCLINICAL QUESTION/LEVELRetrospective case seriesLarge case seriesCare of patientsLife-threatening injuriesComposite tissue allotransplantationSignificant reconstructive challengePotential recipient vesselsReconstructive managementRenal impairmentAntigen sensitizationInitial managementElectrical burnsReconstructive proceduresMicrosurgical reconstructionPatient injuryRecipient vesselsCardiac arrhythmiasTissue allotransplantationInitial Experience of Dual Maintenance Immunosuppression With Steroid Withdrawal in Vascular Composite Tissue Allotransplantation
Diaz-Siso J, Fischer S, Sisk G, Bueno E, Kueckelhaus M, Talbot S, Carty M, Treister N, Marty F, Milford E, Pomahac B, Tullius S. Initial Experience of Dual Maintenance Immunosuppression With Steroid Withdrawal in Vascular Composite Tissue Allotransplantation. American Journal Of Transplantation 2015, 15: 1421-1431. PMID: 25777324, DOI: 10.1111/ajt.13103.Peer-Reviewed Original ResearchConceptsAcute rejectionVCA recipientsMaintenance immunosuppressionSteroid-resistant acute rejectionLate acute rejectionSolid organ transplantationComposite tissue allotransplantationMaintenance steroidsTopical immunosuppressionCurrent immunosuppressionSteroid withdrawalBolus treatmentOrgan transplantationLow doseImmunosuppressionTissue allotransplantationInitial experienceFurther experienceSteroidsRecipientsTacrolimusPatientsTreatmentMonthsLow levels
2014
The Management of Antibody-Mediated Rejection in the First Presensitized Recipient of a Full-Face Allotransplant
Chandraker A, Arscott R, Murphy G, Lian C, Bueno E, Marty F, Rennke H, Milford E, Tullius S, Pomahac B. The Management of Antibody-Mediated Rejection in the First Presensitized Recipient of a Full-Face Allotransplant. American Journal Of Transplantation 2014, 14: 1446-1452. PMID: 24797454, DOI: 10.1111/ajt.12715.Peer-Reviewed Original ResearchConceptsAntibody-mediated rejectionPostoperative day 5Management of AMRDonor-specific antibody titersSubsequent antibody-mediated rejectionGrade III rejectionStandard induction regimenAnti-HLA antibodiesExtensive chemical burnsComposite tissue allotransplantationFull face transplantationMechanism of actionPreoperative crossmatchPresensitized recipientsSensitized recipientsDSA levelsInduction regimenC4d depositsPositive donorsBanff classificationAntibody titersCombination therapyPoor functionHistological signsClinical signs
2013
Vascularized composite tissue allotransplantation – state of the art
Diaz‐Siso J, Bueno E, Sisk G, Marty F, Pomahac B, Tullius S. Vascularized composite tissue allotransplantation – state of the art. Clinical Transplantation 2013, 27: 330-337. PMID: 23581799, PMCID: PMC3724233, DOI: 10.1111/ctr.12117.Peer-Reviewed Original ResearchConceptsImmunosuppression-related side effectsVascularized composite tissue allotransplantationLong-term graft lossEarly post-operative periodChronic graft deteriorationPost-operative periodLong-term outcomesViable treatment optionConventional reconstructive techniquesComposite tissue allotransplantationAcute rejectionGraft lossGraft deteriorationTolerance inductionTreatment optionsLifelong immunosuppressionLower extremitiesImmune responseAnatomic locationReconstructive techniquesAbdominal wallSide effectsTissue allotransplantationFunctional restorationCellular therapy
2012
Infections Following Facial Composite Tissue Allotransplantation—Single Center Experience and Review of the Literature
Knoll B, Hammond S, Koo S, Issa N, Tullius S, Baden L, Pomahac B, Marty F. Infections Following Facial Composite Tissue Allotransplantation—Single Center Experience and Review of the Literature. American Journal Of Transplantation 2012, 13: 770-779. PMID: 23279299, DOI: 10.1111/ajt.12013.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-Infective AgentsCatheter-Related InfectionsCytomegalovirusCytomegalovirus InfectionsFaceFemaleGraft RejectionGraft SurvivalHumansMaleMiddle AgedPneumoniaPostoperative ComplicationsPrognosisSurgical Wound InfectionTissue TransplantationTransplantation, HomologousTrimethoprim, Sulfamethoxazole Drug CombinationConceptsFacial composite tissue allotransplantationCMV diseaseInfectious complicationsPosttransplant infectionsClostridium difficile-associated diarrheaDiscontinuation of prophylaxisEarly posttransplant infectionsSurgical site infectionDifficile-associated diarrheaCatheter-associated infectionsComposite tissue allotransplantationInvasive dermatophyte infectionAdditional prophylaxisBacterial parotitisPerioperative prophylaxisValganciclovir treatmentCenter experienceProphylaxis strategiesSite infectionPolymicrobial bacteremiaRecipient factorsTrimethoprim-sulfamethoxazoleMedical recordsDermatophyte infectionsProphylaxis
2011
Establishing a Composite Tissue Allotransplantation Program
Pomahac B. Establishing a Composite Tissue Allotransplantation Program. Journal Of Reconstructive Microsurgery 2011, 28: 03-06. PMID: 21811966, DOI: 10.1055/s-0031-1285823.Peer-Reviewed Original ResearchConceptsComposite tissue allotransplantationPromising surgical optionPotential patient safety issuesLife-long immunosuppressionPatient safety issuesClinical research interestInstitutional review boardSurgical optionsPostoperative costsWomen's HospitalTissue allotransplantationMultidisciplinary teamMedical careCTA programReview boardHospital administrationLogistic hurdlesMedical insuranceHospitalAdministrationUnited StatesSafety issuesImmunosuppressionPatientsAllotransplantation