2024
C-reactive protein orchestrates acute allograft rejection in vascularized composite allotransplantation via subset-selective monocyte activation
Kiefer J, Zeller J, Schneider L, Thomé J, McFadyen J, Hoerbrand I, Lang F, Deiss E, Bogner B, Schaefer A, Chevalier N, Horner V, Kreuzaler S, Kneser U, Kauke-Navarro M, Braig D, Woollard K, Pomahac B, Peter K, Eisenhardt S. C-reactive protein orchestrates acute allograft rejection in vascularized composite allotransplantation via subset-selective monocyte activation. Journal Of Advanced Research 2024 PMID: 38992424, DOI: 10.1016/j.jare.2024.07.007.Peer-Reviewed Original ResearchAcute allograft rejectionC-reactive proteinVascularized composite allotransplantationAllograft rejectionAcute rejectionAllograft survivalGraft rejectionAttenuate acute allograft rejectionPreventing acute allograft rejectionImmune responseLong-term allograft survivalFacial vascularized composite allotransplantationClinical allograft rejectionReduced allograft survivalChronic allograft rejectionIntravital imagingNon-classical monocytesMarkers of inflammationAcute-phase reactantsImmune-inflammatory reactionPro-inflammatory propertiesMononuclear phagocyte systemAcute-phase responseGraft infiltrationInnate immune responseLymphadenopathy and lymph node rejection following facial vascularized composite allotransplantation
Kauke-Navarro M, Sadigh S, Lee C, Panayi A, Knoedler L, Knoedler S, Stoegner V, Huelsboemer L, Jamil A, Ko C, Lian C, Murphy G, Pomahac B. Lymphadenopathy and lymph node rejection following facial vascularized composite allotransplantation. Journal Of Plastic Reconstructive & Aesthetic Surgery 2024, 91: 268-275. PMID: 38430863, DOI: 10.1016/j.bjps.2024.02.024.Peer-Reviewed Original ResearchLymph nodesVascularized composite allograftsGranzyme BDonor-derived immune cellsFacial vascularized composite allograftMedian time of presentationFacial vascularized composite allotransplantationImmunological processesGranzyme B expressionCytotoxic T cellsNecrotizing histiocytic lymphadenitisHead and neckRetrospective cohort studyTime of presentationStages of follow-upCoexistence of donorFace transplant patientsBilateral adenopathyIncreased histiocytesSuperficial lymph nodesVascularized composite allotransplantationBilateral lymphadenopathyAllograft rejectionTransplant patientsDendritic cells
2019
The Evolving Clinical Presentation of Acute Rejection in Facial Transplantation
Haug V, Kollar B, Obed D, Kiwanuka H, Turk M, Wo L, Tasigiorgos S, Kueckelhaus M, Riella L, Pomahac B. The Evolving Clinical Presentation of Acute Rejection in Facial Transplantation. Facial Plastic Surgery & Aesthetic Medicine 2019, 21: 278-285. PMID: 30998810, PMCID: PMC6646986, DOI: 10.1001/jamafacial.2019.0076.Peer-Reviewed Original ResearchConceptsAcute rejectionSubtherapeutic tacrolimus levelsClinical signsRejection episodesImmunosuppressive therapySubclinical rejectionTacrolimus levelsMedical recordsOdds ratioFacial transplantationDiagnostic valueSignificant associationSingle-center cohort studyLate rejection episodesProtocol skin biopsiesSecond posttransplant yearSymptoms of rejectionTacrolimus blood levelsSecond postoperative yearReliable clinical signFull facial transplantationPostoperative yearPosttransplant yearYears posttransplantationAllograft rejection
2015
Utility of Sentinel Flaps in Assessing Facial Allograft Rejection
Kueckelhaus M, Fischer S, Lian C, Bueno E, Marty F, Tullius S, Pribaz J, Murphy G, Pomahac B. Utility of Sentinel Flaps in Assessing Facial Allograft Rejection. Plastic & Reconstructive Surgery 2015, 135: 250-258. PMID: 25255116, DOI: 10.1097/prs.0000000000000797.Peer-Reviewed Original ResearchConceptsFacial allograftRejection monitoringFasciocutaneous radial forearm flapCLINICAL QUESTION/LEVELSevere rejection episodesFurther surgical proceduresFacial allotransplantationFree fasciocutaneous radial forearm flapRadial forearm flapAxial blood supplyFunctional flapNonfacial sitesRejection episodesLimited skin areaSevere rejectionAllograft rejectionClinical findingsFacial dermatitisFrequent biopsiesBiopsy pairsBiopsy specimensHistologic evaluationSkin biopsiesBlood supplySurgical procedures
2014
Biomarker evaluation of face transplant rejection: association of donor T cells with target cell injury
Lian C, Bueno E, Granter S, Laga A, Saavedra A, Lin W, Susa J, Zhan Q, Chandraker A, Tullius S, Pomahac B, Murphy G. Biomarker evaluation of face transplant rejection: association of donor T cells with target cell injury. Modern Pathology 2014, 27: 788-799. PMID: 24434898, DOI: 10.1038/modpathol.2013.249.Peer-Reviewed Original ResearchConceptsTarget cell injurySkin allograft rejectionDonor T cellsRecipient T cellsT cellsCell injuryAllograft rejectionMemory T cell subsetsAssessment of rejectionFacial transplantT cell subsetsPotential translational significanceImmune cell interactionsRejection episodesClinicopathological assessmentFollicular infundibulumHistologic evidenceSerial biopsiesTransplant rejectionEpidermal targetsDonor originImmune cellsSequential biopsiesDermal microvesselsTranslational significance