2021
Epigenetic states in the human placenta: A singular epigenome for an exceptional tissue
Lesch BJ. Epigenetic states in the human placenta: A singular epigenome for an exceptional tissue. Developmental Cell 2021, 56: 1211-1212. PMID: 33945779, DOI: 10.1016/j.devcel.2021.04.011.Commentaries, Editorials and LettersConceptsPlacental cells
2019
Intergenerational epigenetic inheritance of cancer susceptibility in mammals
Lesch BJ, Tothova Z, Morgan EA, Liao Z, Bronson RT, Ebert BL, Page DC. Intergenerational epigenetic inheritance of cancer susceptibility in mammals. ELife 2019, 8: e39380. PMID: 30963999, PMCID: PMC6456297, DOI: 10.7554/elife.39380.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDisease Models, AnimalEpigenesis, GeneticGenetic Predisposition to DiseaseHistone DemethylasesMiceNeoplasmsWillsConceptsGerm lineEpigenetic changesParental germ lineIntergenerational epigenetic inheritanceRegulation of genesPaternal germ lineCancer susceptibilityChromatin regulatorsEpigenetic inheritanceH3K27me3 marksHypermethylated regionsDNA methylationSomatic tissuesMale gametesElevated tumor incidenceCancer initiationGenetic variantsGermline deletionMutantsHeritabilityDeletionSuccessive generationsSpermOffspringWild-type mice
2014
Poised chromatin in the mammalian germ line
Lesch BJ, Page DC. Poised chromatin in the mammalian germ line. Development 2014, 141: 3619-3626. PMID: 25249456, PMCID: PMC4197577, DOI: 10.1242/dev.113027.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAnimalsChromatinDNA MethylationEpigenesis, GeneticGerm CellsHistonesHumansMiceModels, BiologicalPromoter Regions, GeneticConceptsMammalian germ lineGerm cell identityCell identityGerm lineMammalian germ cellsEmbryonic stem cellsChromatin stateEpigenetic inheritanceHistone modificationsRegulatory genesGene activationDNA methylationEpigenetic featuresChromatinGerm cellsStem cellsSomatic developmentGenesPromoterFetal stageTotipotencyCellsMeiosisGametogenesisRepression
2013
A set of genes critical to development is epigenetically poised in mouse germ cells from fetal stages through completion of meiosis
Lesch BJ, Dokshin GA, Young RA, McCarrey JR, Page DC. A set of genes critical to development is epigenetically poised in mouse germ cells from fetal stages through completion of meiosis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 16061-16066. PMID: 24043772, PMCID: PMC3791702, DOI: 10.1073/pnas.1315204110.Peer-Reviewed Original ResearchConceptsSet of genesGerm cellsPostmeiotic male germ cellsGerm line nucleiSexual differentiationRNA-seq analysisFemale germ cellsSubset of genesEmbryonic stem cellsMale germ cellsRegulators of differentiationEnd of meiosisCompletion of meiosisMouse germ cellsTotipotent zygoteDifferentiated gametesMulticellular organismsGamete precursorsDevelopmental genesChIP-seqGerm lineGamete unionExtraembryonic tissuesMeiotic initiationPostmeiotic cells