2023
KDM6A/UTX promotes spermatogenic gene expression across generations and is not required for male fertility†
Walters B, Rainsford S, Heuer R, Dias N, Huang X, de Rooij D, Lesch B. KDM6A/UTX promotes spermatogenic gene expression across generations and is not required for male fertility†. Biology Of Reproduction 2023, 110: 391-407. PMID: 37861693, PMCID: PMC11484508, DOI: 10.1093/biolre/ioad141.Peer-Reviewed Original ResearchMale germ lineGerm lineGenome-wide epigenetic profilingGene regulatory statesHeritable epigenetic statesHundreds of genesLoss of KDM6AEarly meiotic prophaseSpermatogenic cellsSpermatogenic gene expressionKDM6A/UTXPaternal germ lineDemethylation of H3K27me3H3K27me3 peaksH3K27me3 domainsMisregulated genesEpigenetic stateChromatin organizationRepressive modificationsTranscriptional activatorMammalian spermatogenesisChromatin undergoesLysine demethylase 6AEpigenetic profilingGene activation
2014
Poised chromatin in the mammalian germ line
Lesch BJ, Page DC. Poised chromatin in the mammalian germ line. Development 2014, 141: 3619-3626. PMID: 25249456, PMCID: PMC4197577, DOI: 10.1242/dev.113027.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsMammalian germ lineGerm cell identityCell identityGerm lineMammalian germ cellsEmbryonic stem cellsChromatin stateEpigenetic inheritanceHistone modificationsRegulatory genesGene activationDNA methylationEpigenetic featuresChromatinGerm cellsStem cellsSomatic developmentGenesPromoterFetal stageTotipotencyCellsMeiosisGametogenesisRepression