Sex-biased regulatory changes in the placenta of native highlanders contribute to adaptive fetal development
Yue T, Guo Y, Qi X, Zheng W, Zhang H, Wang B, Liu K, Zhou B, Zeng X, Ouzhuluobu, He Y, Su B. Sex-biased regulatory changes in the placenta of native highlanders contribute to adaptive fetal development. ELife 2024, 12: rp89004. PMID: 38869160, PMCID: PMC11175615, DOI: 10.7554/elife.89004.Peer-Reviewed Original ResearchMeSH KeywordsAltitudeFemaleFetal DevelopmentHumansInfant, NewbornMalePlacentaPregnancySex CharacteristicsSex FactorsTibetTranscriptomeConceptsExpression divergenceHigh birth weightFull-term placentaDecreased immune responseSyncytial knotsMale newbornsEndoplasmic reticulum stressPlacental trophoblastsFetal developmentUmbilical cordBirth weightHan migrantsNative TibetansUmbilical artery wallImmune responseStudy of human reproductionPlacentaAdaptation of human populationsHistological changesBetween-population differencesReticulum stressMigrantsHuman reproductionBetween-populationReproductive success