2024
Sex-biased regulatory changes in the placenta of native highlanders contribute to adaptive fetal development
Yue T, Guo Y, Qi X, Zheng W, Zhang H, Wang B, Liu K, Zhou B, Zeng X, Ouzhuluobu, He Y, Su B. Sex-biased regulatory changes in the placenta of native highlanders contribute to adaptive fetal development. ELife 2024, 12: rp89004. PMID: 38869160, PMCID: PMC11175615, DOI: 10.7554/elife.89004.Peer-Reviewed Original ResearchConceptsExpression divergenceHigh birth weightFull-term placentaDecreased immune responseSyncytial knotsMale newbornsEndoplasmic reticulum stressPlacental trophoblastsFetal developmentUmbilical cordBirth weightHan migrantsNative TibetansUmbilical artery wallImmune responseStudy of human reproductionPlacentaAdaptation of human populationsHistological changesBetween-population differencesReticulum stressMigrantsHuman reproductionBetween-populationReproductive successSUMO-specific protease 1 regulates germinal center B cell response through deSUMOylation of PAX5
Qi J, Yan L, Sun J, Huang C, Su B, Cheng J, Shen L. SUMO-specific protease 1 regulates germinal center B cell response through deSUMOylation of PAX5. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2314619121. PMID: 38776375, PMCID: PMC11145296, DOI: 10.1073/pnas.2314619121.Peer-Reviewed Original ResearchConceptsPaired box protein 5GC B cellsSUMO-specific protease 1Activation-induced cytidine deaminaseProtein SUMOylationClass switch recombinationProtein stabilityB cellsProtease 1B cell responsesProtein 5Cytidine deaminaseSENP1Up-regulatedGC B cell responsesSomatic hypermutationSUMOylationDeSUMOylationGerminal centersHigher affinityProduction of class-switched antibodiesGerminal center B cell responsesGC reactionMemory B cellsClass-switched antibodiesPROTAC EZH2 degrader-1 overcomes the resistance of podophyllotoxin derivatives in refractory small cell lung cancer with leptomeningeal metastasis
Shi M, Ding X, Tang L, Cao W, Su B, Zhang J. PROTAC EZH2 degrader-1 overcomes the resistance of podophyllotoxin derivatives in refractory small cell lung cancer with leptomeningeal metastasis. BMC Cancer 2024, 24: 504. PMID: 38644473, PMCID: PMC11034131, DOI: 10.1186/s12885-024-12244-3.Peer-Reviewed Original ResearchConceptsSmall cell lung cancerCell lung cancerMouse modelLung cancerRefractory small cell lung cancerNude miceIn vivo drug testingCell linesDrug testingLM cellsSensitivity of cisplatinIn vitro drug testingIncreased in vitroBackgroundLeptomeningeal metastasisLeptomeningeal metastasesSevere neurological disordersAssociated with several neurological disordersDrug sensitivityIn vivo live imagingHistological examinationCarotid arteryEffective treatmentMetastasisDrug trialsExpressing luciferaseChanges of Mycobacterium tuberculosis specific antigen-stimulated CD27−CD38+IFN-γ+CD4+ T cells before and after anti-tuberculosis treatment
Fang Y, Tang Y, Luo Q, Wang N, Tang L, Yang X, You X, Wang Y, Liang L, Zhang J, Su B, Sha W. Changes of Mycobacterium tuberculosis specific antigen-stimulated CD27−CD38+IFN-γ+CD4+ T cells before and after anti-tuberculosis treatment. European Journal Of Medical Research 2024, 29: 147. PMID: 38429734, PMCID: PMC10908161, DOI: 10.1186/s40001-024-01713-x.Peer-Reviewed Original ResearchConceptsLatent TB infectionAnti-TB treatmentPulmonary TB patientsT cellsHealthy controlsPTB patientsTB patientsActive pulmonary TB patientsLTBI casesAnti-tuberculosis treatmentAnti-TB regimenErythrocyte sedimentation rateC-reactive proteinArea under receiver operating characteristic curveESAT-6/CFP-10Treatment courseProtein 10TB infectionCFP-10Severity scoreBackgroundThe aimAnti-tuberculosisPatientsMonthsTreatmentTransformation to small cell lung cancer is irrespective of EGFR and accelerated by SMAD4-mediated ASCL1 transcription independently of RB1 in non-small cell lung cancer
Ding X, Shi M, Liu D, Cao J, Zhang K, Zhang R, Zhang L, Ai K, Su B, Zhang J. Transformation to small cell lung cancer is irrespective of EGFR and accelerated by SMAD4-mediated ASCL1 transcription independently of RB1 in non-small cell lung cancer. Cell Communication And Signaling 2024, 22: 45. PMID: 38233864, PMCID: PMC10795321, DOI: 10.1186/s12964-023-01260-8.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerSmall cell lung cancerSmall cell lung cancer transformationCell lung cancerTransformation to small cell lung cancerLung cancerEGFR-mutant non-small cell lung cancerMYC inhibitorsNon-small cell lung cancer patientsMechanisms of TKI resistanceEGFR mutation statusResistant lung cancerNon-small cell lung cancer cellsDriver gene statusPhenotype in vitroCancer-related genesPotential functional genesPutative gene functionsCRISPR-Cas 9SCLC transformationTKI resistanceMutation statusNeuroendocrine phenotypeRB1 statusClinical characteristics
2020
Tracing the Genetic Legacy of the Tibetan Empire in the Balti
Yang X, Rakha A, Chen W, Hou J, Qi X, Shen Q, Dai S, Sulaiman X, Abdulloevich N, Afanasevna M, Ibrohimovich K, Chen X, Yang W, Adnan A, Zhao R, Yao Y, Su B, Peng M, Zhang Y. Tracing the Genetic Legacy of the Tibetan Empire in the Balti. Molecular Biology And Evolution 2020, 38: 1529-1536. PMID: 33283852, PMCID: PMC8042757, DOI: 10.1093/molbev/msaa313.Peer-Reviewed Original ResearchConceptsAnalysis of mitochondrial DNATibetan EmpireX chromosome dataMale-biased dispersalAdmixture eventsDemographic historyMitochondrial DNAGenetic legacyGenetic impactTibetan ancestryCourse of historyDemic diffusionGenomeEast EurasiaEmpireTibetan malesBaltistanHistoryAncestryDNABaltiGeneticsTibetanTibetan languagePeople
2011
mTOR Complex 2 Targets Akt for Proteasomal Degradation via Phosphorylation at the Hydrophobic Motif*
Wu YT, Ouyang W, Lazorchak AS, Liu D, Shen HM, Su B. mTOR Complex 2 Targets Akt for Proteasomal Degradation via Phosphorylation at the Hydrophobic Motif*. Journal Of Biological Chemistry 2011, 286: 14190-14198. PMID: 21321111, PMCID: PMC3077620, DOI: 10.1074/jbc.m111.219923.Peer-Reviewed Original ResearchConceptsAkt Ser-473 phosphorylationSer-473 phosphorylationAkt activationMotif phosphorylationHydrophobic motifProteasomal degradationHydrophobic motif phosphorylationLys-48-linked polyubiquitinationPhosphorylation-dependent ubiquitinationRapid proteasomal degradationProtein kinase AktRapamycin complex 2Protein life cycleDiverse human diseasesFull Akt activationActivity of AktNegative feedback regulationCellular stimuliKinase AktDependent phosphorylationProtein degradationTarget AktAkt activityHuman diseasesAkt protein
2008
The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C
Facchinetti V, Ouyang W, Wei H, Soto N, Lazorchak A, Gould C, Lowry C, Newton AC, Mao Y, Miao RQ, Sessa WC, Qin J, Zhang P, Su B, Jacinto E. The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. The EMBO Journal 2008, 27: 1932-1943. PMID: 18566586, PMCID: PMC2486276, DOI: 10.1038/emboj.2008.120.Peer-Reviewed Original ResearchConceptsTarget of rapamycinProtein kinase CTOR complex 1Functions of TORRapamycin-sensitive TOR complex 1Site phosphorylationKinase CTurn motif siteProtein synthesisStability of AktConventional protein kinase CTORC2 functionTOR functionTOR pathwayPhosphorylation of AktHM siteKinase domainProtein foldingMotif sitesProteasome degradationNovel functionBasic residuesMammalian targetPhosphorylationAkt
2006
SIN1/MIP1 Maintains rictor-mTOR Complex Integrity and Regulates Akt Phosphorylation and Substrate Specificity
Jacinto E, Facchinetti V, Liu D, Soto N, Wei S, Jung SY, Huang Q, Qin J, Su B. SIN1/MIP1 Maintains rictor-mTOR Complex Integrity and Regulates Akt Phosphorylation and Substrate Specificity. Cell 2006, 127: 125-137. PMID: 16962653, DOI: 10.1016/j.cell.2006.08.033.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsCarrier ProteinsCells, CulturedFibroblastsForkhead Box Protein O1Forkhead Box Protein O3Forkhead Transcription FactorsGene SilencingHumansMiceMice, Inbred C57BLMice, KnockoutMultiprotein ComplexesPhosphoproteinsPhosphorylationProtein KinasesProteinsProto-Oncogene Proteins c-aktRapamycin-Insensitive Companion of mTOR ProteinRegulatory-Associated Protein of mTORSignal TransductionSubstrate SpecificityThreonineTOR Serine-Threonine KinasesTranscription FactorsConceptsAkt Ser473 phosphorylationAkt targetsSer473 phosphorylationAkt/PKB Ser473 phosphorylationPKB Ser473 phosphorylationRecent biochemical studiesTORC2 functionTORC1 functionHydrophobic motifProtein complexesRaptor-mTORMTOR functionActivation loopPhosphorylation sitesAkt functionSubstrate specificityComplex integrityS6KRegulatory mechanismsCell survivalPhosphorylationMammalian targetPhysiological importanceAkt phosphorylationBiochemical studies