MEKK3 Is Essential for Lymphopenia-Induced T Cell Proliferation and Survival
Wang X, Chang X, Facchinetti V, Zhuang Y, Su B. MEKK3 Is Essential for Lymphopenia-Induced T Cell Proliferation and Survival. The Journal Of Immunology 2009, 182: 3597-3608. PMID: 19265138, PMCID: PMC2923428, DOI: 10.4049/jimmunol.0803738.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell DifferentiationCell ProliferationCell SurvivalCells, CulturedGene Knock-In TechniquesHomeostasisLymphopeniaMAP Kinase Kinase Kinase 3MiceMice, Inbred C57BLMice, KnockoutMice, TransgenicMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Thymus GlandConceptsT cell proliferationT cell homeostasisT cellsCell proliferationPeripheral T cell numbersSelf-peptide MHCTCR stimulationT cell immunityT cell numbersThymic T cell developmentConditional knockout miceCell homeostasisT cell developmentCell immunityActivity of ERK1/2Knockout miceConditional ablationPeptide-MHCP38 MAPKLymphopeniaCell numberSignificant reductionCell developmentSelective roleProliferation