Identification of MEKK2/3 serine phosphorylation site targeted by the Toll‐like receptor and stress pathways
Zhang D, Facchinetti V, Wang X, Huang Q, Qin J, Su B. Identification of MEKK2/3 serine phosphorylation site targeted by the Toll‐like receptor and stress pathways. The EMBO Journal 2005, 25: 97-107. PMID: 16362041, PMCID: PMC1356356, DOI: 10.1038/sj.emboj.7600913.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntibodies, Phospho-SpecificCytokinesEnzyme ActivationInterleukin-6LigandsLipopolysaccharidesMAP Kinase Kinase Kinase 2MAP Kinase Kinase Kinase 3Molecular Sequence DataMutationPhosphoamino AcidsPhosphorylationProtein Kinase InhibitorsSerineTNF Receptor-Associated Factor 6Toll-Like Receptor 4Toll-Like ReceptorsConceptsPhosphorylation sitesSerine phosphorylationMitogen-activated protein kinase kinase kinase (MAP3K) familyMolecular mechanismsProtein kinase kinase kinase familyToll-like receptorsStress pathwaysRegulatory phosphorylation sitesSerine phosphorylation sitesCellular stress responseCellular stress pathwaysNovel molecular mechanismDifferent cellular responsesKey adaptor moleculeMEKK3 phosphorylationRegulatory serineKinase familyAdaptor moleculeStress responseCellular responsesK activationMAPK agonistsPhosphorylationMEKK2Pathway