2024
Transformation to small cell lung cancer is irrespective of EGFR and accelerated by SMAD4-mediated ASCL1 transcription independently of RB1 in non-small cell lung cancer
Ding X, Shi M, Liu D, Cao J, Zhang K, Zhang R, Zhang L, Ai K, Su B, Zhang J. Transformation to small cell lung cancer is irrespective of EGFR and accelerated by SMAD4-mediated ASCL1 transcription independently of RB1 in non-small cell lung cancer. Cell Communication And Signaling 2024, 22: 45. PMID: 38233864, PMCID: PMC10795321, DOI: 10.1186/s12964-023-01260-8.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerSmall cell lung cancerSmall cell lung cancer transformationCell lung cancerTransformation to small cell lung cancerLung cancerEGFR-mutant non-small cell lung cancerMYC inhibitorsNon-small cell lung cancer patientsMechanisms of TKI resistanceEGFR mutation statusResistant lung cancerNon-small cell lung cancer cellsDriver gene statusPhenotype in vitroCancer-related genesPotential functional genesPutative gene functionsCRISPR-Cas 9SCLC transformationTKI resistanceMutation statusNeuroendocrine phenotypeRB1 statusClinical characteristics
2005
Identification of MEKK2/3 serine phosphorylation site targeted by the Toll‐like receptor and stress pathways
Zhang D, Facchinetti V, Wang X, Huang Q, Qin J, Su B. Identification of MEKK2/3 serine phosphorylation site targeted by the Toll‐like receptor and stress pathways. The EMBO Journal 2005, 25: 97-107. PMID: 16362041, PMCID: PMC1356356, DOI: 10.1038/sj.emboj.7600913.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntibodies, Phospho-SpecificCytokinesEnzyme ActivationInterleukin-6LigandsLipopolysaccharidesMAP Kinase Kinase Kinase 2MAP Kinase Kinase Kinase 3Molecular Sequence DataMutationPhosphoamino AcidsPhosphorylationProtein Kinase InhibitorsSerineTNF Receptor-Associated Factor 6Toll-Like Receptor 4Toll-Like ReceptorsConceptsPhosphorylation sitesSerine phosphorylationMitogen-activated protein kinase kinase kinase (MAP3K) familyMolecular mechanismsProtein kinase kinase kinase familyToll-like receptorsStress pathwaysRegulatory phosphorylation sitesSerine phosphorylation sitesCellular stress responseCellular stress pathwaysNovel molecular mechanismDifferent cellular responsesKey adaptor moleculeMEKK3 phosphorylationRegulatory serineKinase familyAdaptor moleculeStress responseCellular responsesK activationMAPK agonistsPhosphorylationMEKK2Pathway