The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C
Facchinetti V, Ouyang W, Wei H, Soto N, Lazorchak A, Gould C, Lowry C, Newton AC, Mao Y, Miao RQ, Sessa WC, Qin J, Zhang P, Su B, Jacinto E. The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. The EMBO Journal 2008, 27: 1932-1943. PMID: 18566586, PMCID: PMC2486276, DOI: 10.1038/emboj.2008.120.Peer-Reviewed Original ResearchConceptsTarget of rapamycinProtein kinase CTOR complex 1Functions of TORRapamycin-sensitive TOR complex 1Site phosphorylationKinase CTurn motif siteProtein synthesisStability of AktConventional protein kinase CTORC2 functionTOR functionTOR pathwayPhosphorylation of AktHM siteKinase domainProtein foldingMotif sitesProteasome degradationNovel functionBasic residuesMammalian targetPhosphorylationAkt