Weakened tanning ability is an important mechanism for evolutionary skin lightening in East Asians
Pu Y, Pu S, Chen Y, Kong Q, Liu X, Zhao Q, Xu K, Liu J, Li M, Xu X, Qiao X, Su B, Chen J, Yang Z. Weakened tanning ability is an important mechanism for evolutionary skin lightening in East Asians. Journal Of Genetics And Genomics 2024, 51: 703-713. PMID: 38461943, DOI: 10.1016/j.jgg.2024.03.001.Peer-Reviewed Original ResearchBinding activity of transcription factorsActivation of transcription factorsEast AsiansTranscription factor binding assaysBinding to Smad2Zebrafish embryosHan Chinese individualsEnhanced activityAdaptive allelesAssociated with skin colorAncestral alleleHigh-latitude environmentsHan Chinese malesPigment genesIntronic mutationTanning abilityTranscription factorsGenetic mechanismsSelection signalsT alleleUltraviolet radiation responsesNatural selectionLight skin pigmentationMelanin productionBinding activity