Disulfiram/copper complex improves the effectiveness of the WEE1 inhibitor Adavosertib in p53 deficient non-small cell lung cancer via ferroptosis
Liu D, Cao J, Ding X, Xu W, Yao X, Dai M, Tai Q, Shi M, Fei K, Xu Y, Su B. Disulfiram/copper complex improves the effectiveness of the WEE1 inhibitor Adavosertib in p53 deficient non-small cell lung cancer via ferroptosis. Biochimica Et Biophysica Acta (BBA) - Molecular Basis Of Disease 2024, 1870: 167455. PMID: 39111630, DOI: 10.1016/j.bbadis.2024.167455.Peer-Reviewed Original ResearchWEE1 inhibitorNon-small cell lung cancerNSCLC cellsCell lung cancerSynergistic therapeutic approachesProtein levelsEffective treatment strategiesPro-oxidant drugsKinase activity of Wee1P53-deficient cellsActivity of Wee1Tumor volumeCombination therapyDSF-CuRepurposing disulfiramTumor weightSolute carrier family 7 memberWee1 protein levelsP53 deficiencyPoor prognosisReduced cell viabilityFunctional p53Lung cancerTreatment strategiesXenograft model