SIN1/MIP1 Maintains rictor-mTOR Complex Integrity and Regulates Akt Phosphorylation and Substrate Specificity
Jacinto E, Facchinetti V, Liu D, Soto N, Wei S, Jung SY, Huang Q, Qin J, Su B. SIN1/MIP1 Maintains rictor-mTOR Complex Integrity and Regulates Akt Phosphorylation and Substrate Specificity. Cell 2006, 127: 125-137. PMID: 16962653, DOI: 10.1016/j.cell.2006.08.033.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsCarrier ProteinsCells, CulturedFibroblastsForkhead Box Protein O1Forkhead Box Protein O3Forkhead Transcription FactorsGene SilencingHumansMiceMice, Inbred C57BLMice, KnockoutMultiprotein ComplexesPhosphoproteinsPhosphorylationProtein KinasesProteinsProto-Oncogene Proteins c-aktRapamycin-Insensitive Companion of mTOR ProteinRegulatory-Associated Protein of mTORSignal TransductionSubstrate SpecificityThreonineTOR Serine-Threonine KinasesTranscription FactorsConceptsAkt Ser473 phosphorylationAkt targetsSer473 phosphorylationAkt/PKB Ser473 phosphorylationPKB Ser473 phosphorylationRecent biochemical studiesTORC2 functionTORC1 functionHydrophobic motifProtein complexesRaptor-mTORMTOR functionActivation loopPhosphorylation sitesAkt functionSubstrate specificityComplex integrityS6KRegulatory mechanismsCell survivalPhosphorylationMammalian targetPhysiological importanceAkt phosphorylationBiochemical studies