TWIST1+FAP+ fibroblasts in the pathogenesis of intestinal fibrosis in Crohn’s disease
Zhang Y, Wang J, Sun H, Xun Z, He Z, Zhao Y, Qi J, Sun S, Yang Q, Gu Y, Zhang L, Zhou C, Ye Y, Wu N, Zou D, Su B. TWIST1+FAP+ fibroblasts in the pathogenesis of intestinal fibrosis in Crohn’s disease. Journal Of Clinical Investigation 2024, 134: e179472. PMID: 39024569, PMCID: PMC11405050, DOI: 10.1172/jci179472.Peer-Reviewed Original ResearchExcessive extracellular matrixComplication of Crohn's diseaseDextran sulfate sodium saltSingle-cell RNA sequencingMesenchymal stromal cellsTGF-b signalingScRNA-seqCrohn's diseaseIntestinal fibrosisCell transcriptomic profilingRNA sequencingTranscriptome profilingSingle cell transcriptomic profilingInhibition of Twist1Murine colitis modelPathogenesis of intestinal fibrosisAnti-fibrosis drugsExtracellular matrixPharmacological inhibitionFibrotic intestineFibrotic sitesTwist1 expressionECM productionCD patientsIntestinal obstruction